{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T10:25:46Z","timestamp":1791195946503,"version":"4.1.0"},"reference-count":15,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2026,4,12]],"date-time":"2026-04-12T00:00:00Z","timestamp":1775952000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,4,12]],"date-time":"2026-04-12T00:00:00Z","timestamp":1775952000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Forensic Sciences"],"published-print":{"date-parts":[[2026,7]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Sudden and unexpected natural death presents a diagnostic challenge in forensic practice, as the underlying cause often remains unclear before death. Acute gastrointestinal hemorrhage due to gastric tumors, such as gastrointestinal stromal tumors (GISTs), is an uncommon cause of sudden death. GISTs are primary mesenchymal tumors of the gastrointestinal tract and most frequently arise in the stomach. To the best of our knowledge, this is the first reported case of sudden and unexpected death due to acute hemorrhage from a GIST. This case report describes a medico\u2010legal autopsy of a 62\u2010year\u2010old Indian male who presented with hematemesis, became unconscious, and died shortly after hospital admission. Internal examination revealed a well\u2010circumscribed nodular tumor along the greater curvature of the stomach, associated with massive intragastric and intestinal hemorrhage. Histopathological examination showed a spindle\u2010cell tumor composed of cells arranged in fascicles and whorls, with low mitotic activity and no evidence of necrosis. Immunohistochemical analysis demonstrated strong positivity for DOG\u20101 and H\u2010Caldesmon, confirming the diagnosis of a gastric GIST. This case report highlights the importance and seriousness of GIST even when it falls in the low\u2010risk category. In this case, GISTs presented with fatal upper gastrointestinal hemorrhage encountered during medico\u2010legal autopsy in a case of sudden death.<\/jats:p>","DOI":"10.1111\/1556-4029.70332","type":"journal-article","created":{"date-parts":[[2026,4,13]],"date-time":"2026-04-13T04:41:41Z","timestamp":1776055301000},"page":"1910-1914","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["A rare case of sudden death due to hemorrhage in a gastrointestinal stromal tumor"],"prefix":"10.1111","volume":"71","author":[{"given":"Nirmal","family":"Nagar","sequence":"first","affiliation":[{"name":"Department of Forensic Medicine and Toxicology All India Institute of Medical Sciences (AIIMS)  Rishikesh Uttarakhand India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lakhan Lal","family":"Navlani","sequence":"additional","affiliation":[{"name":"Department of Forensic Medicine and Toxicology All India Institute of Medical Sciences (AIIMS)  Rishikesh Uttarakhand India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arvind","family":"Kumar","sequence":"additional","affiliation":[{"name":"Department of Pathology All India Institute of Medical Sciences (AIIMS)  Rishikesh Uttarakhand India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Binaya Kumar","family":"Bastia","sequence":"additional","affiliation":[{"name":"Department of Forensic Medicine and Toxicology All India Institute of Medical Sciences (AIIMS)  Rishikesh Uttarakhand India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,4,12]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.3390\/healthcare9070870"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1177\/0025802417737001"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/s004280000338"},{"issue":"5","key":"e_1_2_8_5_1","first-page":"1259","article-title":"Gastrointestinal pacemaker cell tumor (GIPACT): gastrointestinal stromal tumors show phenotypic characteristics of the interstitial cells of Cajal","volume":"152","author":"Kindblom LG","year":"1998","journal-title":"Am J 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