{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T08:50:59Z","timestamp":1791363059118,"version":"4.3.1"},"reference-count":25,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T00:00:00Z","timestamp":1791331200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T00:00:00Z","timestamp":1791331200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82502277"],"award-info":[{"award-number":["82502277"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Forensic Sciences"],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    In recent years, new psychoactive substances (NPSs) have emerged continuously, often concealed in carriers such as blotter stamps, tobacco, and beverages, posing serious challenges to drug control and forensic identification. In this study, seven phenethylamine substances were detected from a seized blotter stamp using liquid chromatography\u2013high\u2010resolution mass spectrometry (LC\u2010HRMS). By comparison with an in\u2010house mass spectral library, six of them were identified as 25D\u2010NBOMe, 25E\u2010NBOH, 25C\u2010NBOMe, 2C\u2010E, 25B\u2010NBOMe, and 25I\u2010NBOH. The most abundant component exhibited a protonated molecular ion ([M\u2009+\u2009H]\n                    <jats:sup>+<\/jats:sup>\n                    ) at\n                    <jats:italic>m\/z<\/jats:italic>\n                    330.2068; the relative peak area percentage of this component among the seven identified analytes was approximately 94.6%. Further comparison with the in\u2010house library indicated that this substance could be either 25G\u2010NBOMe or 25E\u2010NBOMe, which were structural isomers of each other. Conventional liquid chromatography\u2013tandem mass spectrometry (LC\u2013MS\/MS) methods relying primarily on retention time and selected parent\/product ion pairs were insufficient to confidently distinguish these two structural isomers, posing a risk of misidentification. Therefore, this study employed HRMS combined with diagnostic fragment ion abundance ratio analysis. It was found that under identical collision energy conditions, the fragment ions at\n                    <jats:italic>m\/z<\/jats:italic>\n                    135.0804 and 193.1223 exhibited markedly stronger responses for 25E\u2010NBOMe than for 25G\u2010NBOMe. Based on this, we distinguished the two structural isomers and confirmed that the target substance in the seized blotter stamp was 25E\u2010NBOMe.\n                  <\/jats:p>","DOI":"10.1111\/1556-4029.70492","type":"journal-article","created":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T08:05:20Z","timestamp":1791360320000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["One blotter stamp: Identification of multiple phenethylamine new psychoactive substances and unambiguous differentiation of two isomers"],"prefix":"10.1111","author":[{"ORCID":"https:\/\/orcid.org\/0009-0005-8662-7043","authenticated-orcid":false,"given":"Jialin","family":"Feng","sequence":"first","affiliation":[{"name":"School of Pharmacy Shenyang Pharmaceutical University  Shenyang China"},{"name":"Department of Forensic Toxicology, Academy of Forensic Science, Shanghai Key Laboratory of Forensic Medicine, Shanghai Forensic Science Platform, Key Laboratory of Forensic Sciences Ministry of Justice  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-6309-642X","authenticated-orcid":false,"given":"Miao","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Forensic Toxicology, Academy of Forensic Science, Shanghai Key Laboratory of Forensic Medicine, Shanghai Forensic Science Platform, Key Laboratory of Forensic Sciences Ministry of Justice  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9665-4292","authenticated-orcid":false,"given":"Ping","family":"Xiang","sequence":"additional","affiliation":[{"name":"Department of Forensic Toxicology, Academy of Forensic Science, Shanghai Key Laboratory of Forensic Medicine, Shanghai Forensic Science Platform, Key Laboratory of Forensic Sciences Ministry of Justice  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miao","family":"Yu","sequence":"additional","affiliation":[{"name":"School of Pharmacy Shenyang Pharmaceutical University  Shenyang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8217-4965","authenticated-orcid":false,"given":"Junbo","family":"Zhao","sequence":"additional","affiliation":[{"name":"Department of Forensic Toxicology, Academy of Forensic Science, Shanghai Key Laboratory of Forensic Medicine, Shanghai Forensic Science Platform, Key Laboratory of Forensic Sciences Ministry of Justice  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,10,7]]},"reference":[{"key":"e_1_2_10_2_1","unstructured":"UNODC.Early warning advisory on new psychoactive substances: What are NPS?https:\/\/www.unodc.org\/LSS\/Page\/NPS.html. Accessed 13 Oct 2025."},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1097\/yco.0000000000000612"},{"key":"e_1_2_10_4_1","unstructured":"European Monitoring Centre for Drugs and Drug Addiction (EMCDDA).European Drug Report 2021: Trends and Developments.https:\/\/www.emcdda.europa.eu\/system\/files\/publications\/13838\/TDAT21001ENN.pdf(2021). Accessed 6 Mar 2022."},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.forsciint.2017.02.025"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/dta.2751"},{"key":"e_1_2_10_7_1","unstructured":"United Nations.The convention on psychotropic substances of 1971.https:\/\/www.unodc.org\/pdf\/convention_1971_en.pdf(1971). Accessed 21 Sep 2022."},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.forsciint.2019.05.036"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11419\u2010019\u201000496\u20109"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/1556\u20104029.15224"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1039\/d4an01361a"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1080\/15563650.2022.2053150"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.2174\/1570159x13666141210222409"},{"key":"e_1_2_10_14_1","unstructured":"UNODC.World Drug Report 2022. Chapter\u00a06 New Psychoactive Substances.https:\/\/www.unodc.org\/res\/wdr2022\/MS\/WDR22_Booklet_4.pdf. 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