{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T14:40:39Z","timestamp":1791297639556,"version":"4.1.0"},"reference-count":35,"publisher":"Oxford University Press (OUP)","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["FEMS Microbiol Lett"],"published-print":{"date-parts":[[2014,1]]},"DOI":"10.1111\/1574-6968.12299","type":"journal-article","created":{"date-parts":[[2013,10,26]],"date-time":"2013-10-26T10:02:39Z","timestamp":1382781759000},"page":"100-106","source":"Crossref","is-referenced-by-count":66,"title":["Cytosine DNA methylation influences drug resistance in<i>Escherichia coli<\/i>through increased<i>sugE<\/i>expression"],"prefix":"10.1093","volume":"350","author":[{"given":"Kevin T.","family":"Militello","sequence":"first","affiliation":[{"name":"Department of Biology; State University of New York at Geneseo; Geneseo NY USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexandra H.","family":"Mandarano","sequence":"additional","affiliation":[{"name":"Department of Biology; State University of New York at Geneseo; Geneseo NY USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olga","family":"Varechtchouk","sequence":"additional","affiliation":[{"name":"Department of Biology; State University of New York at Geneseo; Geneseo NY USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert D.","family":"Simon","sequence":"additional","affiliation":[{"name":"Department of Biology; State University of New York at Geneseo; Geneseo NY USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2013,11,6]]},"reference":[{"key":"10.1111\/1574-6968.12299-BIB0001|fml12299-cit-0001","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/msb4100050","article-title":"Construction of Escherichia coli K-12 in-frame, single-gene knockout mutants: the Keio collection","volume":"2","author":"Baba","year":"2006","journal-title":"Mol Syst Biol"},{"key":"10.1111\/1574-6968.12299-BIB0002|fml12299-cit-0002","doi-asserted-by":"crossref","first-page":"7851","DOI":"10.1074\/jbc.271.13.7851","article-title":"Overproduction of DNA cytosine methyltransferases causes methylation and CT mutations at non-canonical sites","volume":"271","author":"Bandaru","year":"1996","journal-title":"J Biol Chem"},{"key":"10.1111\/1574-6968.12299-BIB0003|fml12299-cit-0003","doi-asserted-by":"crossref","first-page":"1055","DOI":"10.1099\/mic.0.28624-0","article-title":"An orphan DNA (cytosine-5-)-methyltransferase in Vibrio cholerae","volume":"152","author":"Banerjee","year":"2006","journal-title":"Microbiology"},{"key":"10.1111\/1574-6968.12299-BIB0004|fml12299-cit-0004","doi-asserted-by":"crossref","first-page":"1814","DOI":"10.1016\/j.bbamem.2007.08.015","article-title":"Small multidrug resistance proteins: a multidrug transporter family that continues to grow","volume":"1778","author":"Bay","year":"2008","journal-title":"Biochim Biophys Acta"},{"key":"10.1111\/1574-6968.12299-BIB0005|fml12299-cit-0005","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1016\/j.dnarep.2009.11.006","article-title":"Use of Drosophila deoxynucleoside kinase to study mechanism of toxicity and mutagenicity of deoxycytidine analogs in Escherichia coli","volume":"9","author":"Betham","year":"2010","journal-title":"DNA Repair (Amst)"},{"key":"10.1111\/1574-6968.12299-BIB0006|fml12299-cit-0006","doi-asserted-by":"crossref","first-page":"1421","DOI":"10.1046\/j.1365-2958.2002.02989.x","article-title":"Cooperation and competition in mismatch repair: very short-patch repair and methyl-directed mismatch repair in Escherichia coli","volume":"44","author":"Bhagwat","year":"2002","journal-title":"Mol Microbiol"},{"key":"10.1111\/1574-6968.12299-BIB0007|fml12299-cit-0007","doi-asserted-by":"crossref","first-page":"1537","DOI":"10.1128\/jb.169.4.1537-1546.1987","article-title":"Genetic analysis of the 5-azacytidine sensitivity of Escherichia coli K-12","volume":"169","author":"Bhagwat","year":"1987","journal-title":"J Bacteriol"},{"key":"10.1111\/1574-6968.12299-BIB0008|fml12299-cit-0008","doi-asserted-by":"crossref","first-page":"2543","DOI":"10.1128\/JB.184.9.2543-2545.2002","article-title":"Overexpression of the Escherichia coli sugE gene confers resistance to a narrow range of quaternary ammonium compounds","volume":"184","author":"Chung","year":"2002","journal-title":"J Bacteriol"},{"key":"10.1111\/1574-6968.12299-BIB0009|fml12299-cit-0009","doi-asserted-by":"crossref","first-page":"39","DOI":"10.2323\/jgam.59.47","article-title":"sugE: a gene involved in tributyltin (TBT) resistance of Aeromonas molluscorum Av27","volume":"59","author":"Cruz","year":"2013","journal-title":"J Gen Appl Microbiol"},{"key":"10.1111\/1574-6968.12299-BIB0010|fml12299-cit-0010","doi-asserted-by":"crossref","first-page":"2389","DOI":"10.1128\/JB.02112-12","article-title":"Characterization of undermethylated sites in Vibrio cholerae","volume":"195","author":"Dalia","year":"2013","journal-title":"J Bacteriol"},{"key":"10.1111\/1574-6968.12299-BIB0011|fml12299-cit-0011","doi-asserted-by":"crossref","first-page":"889","DOI":"10.1002\/j.1460-2075.1993.tb05729.x","article-title":"A novel multicopy suppressor of a groEL mutation includes two nested open reading frames transcribed from different promoters","volume":"12","author":"Greener","year":"1993","journal-title":"EMBO J"},{"key":"10.1111\/1574-6968.12299-BIB0012|fml12299-cit-0012","doi-asserted-by":"crossref","first-page":"1103","DOI":"10.1128\/JB.115.3.1103-1107.1973","article-title":"Isolation of a mutant of Escherichia coli defective in cytosine-specific deoxyribonucleic acid methylase activity and in partial protection of bacteriophage lambda against restriction by cells containing the N-3 drug-resistance factor","volume":"115","author":"Hattman","year":"1973","journal-title":"J Bacteriol"},{"key":"10.1111\/1574-6968.12299-BIB0013|fml12299-cit-0013","doi-asserted-by":"crossref","first-page":"3954","DOI":"10.1128\/AAC.00094-11","article-title":"SugE, a new member of the SMR family of transporters, contributes to antimicrobial resistance in Enterobacter cloacae","volume":"55","author":"He","year":"2011","journal-title":"Antimicrob Agents Chemother"},{"key":"10.1111\/1574-6968.12299-BIB0014|fml12299-cit-0014","doi-asserted-by":"crossref","first-page":"776","DOI":"10.1038\/353776a0","article-title":"The vsr gene product of E.\u00a0coli K-12 is a strand- and sequence-specific DNA mismatch endonuclease","volume":"353","author":"Hennecke","year":"1991","journal-title":"Nature"},{"key":"10.1111\/1574-6968.12299-BIB0015|fml12299-cit-0015","doi-asserted-by":"crossref","first-page":"31717","DOI":"10.1074\/jbc.M305448200","article-title":"The human Dnmt2 has residual DNA-(cytosine-C5) methyltransferase activity","volume":"278","author":"Hermann","year":"2003","journal-title":"J Biol Chem"},{"key":"10.1111\/1574-6968.12299-BIB0016|fml12299-cit-0016","doi-asserted-by":"crossref","first-page":"274","DOI":"10.1002\/1439-7633(20020402)3:4<274::AID-CBIC274>3.0.CO;2-S","article-title":"Beyond Watson and Crick: DNA methylation and molecular enzymology of DNA methyltransferases","volume":"3","author":"Jeltsch","year":"2002","journal-title":"ChemBioChem"},{"key":"10.1111\/1574-6968.12299-BIB0017|fml12299-cit-0017","doi-asserted-by":"crossref","first-page":"886","DOI":"10.1038\/ncomms1878","article-title":"Genomics of DNA cytosine methylation in Escherichia coli reveals its role in stationary phase transcription","volume":"3","author":"Kahramanoglou","year":"2012","journal-title":"Nat Commun"},{"key":"10.1111\/1574-6968.12299-BIB0019|fml12299-cit-0019","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1093\/genetics\/128.1.23","article-title":"Spontaneous mutation at a 5-methylcytosine hotspot is prevented by very short patch (VSP) mismatch repair","volume":"128","author":"Lieb","year":"1991","journal-title":"Genetics"},{"key":"10.1111\/1574-6968.12299-BIB0020|fml12299-cit-0020","doi-asserted-by":"crossref","first-page":"467","DOI":"10.1046\/j.1365-2958.1996.5291066.x","article-title":"Very short patch repair: reducing the cost of cytosine methylation","volume":"20","author":"Lieb","year":"1996","journal-title":"Mol Microbiol"},{"key":"10.1111\/1574-6968.12299-BIB0021|fml12299-cit-0021","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1006\/meth.2001.1262","article-title":"Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) Method","volume":"25","author":"Livak","year":"2001","journal-title":"Methods"},{"key":"10.1111\/1574-6968.12299-BIB0022|fml12299-cit-0022","first-page":"1","volume-title":"EcoSal - Escherichia coli and Salmonella: Cellular and Molecular Biology","author":"Marinus","year":"2009"},{"key":"10.1111\/1574-6968.12299-BIB0024|fml12299-cit-0024","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1111\/j.1574-6968.2011.02482.x","article-title":"Conservation of Dcm-mediated cytosine DNA methylation in Escherichia coli","volume":"328","author":"Militello","year":"2012","journal-title":"FEMS Microbiol Lett"},{"key":"10.1111\/1574-6968.12299-BIB0025|fml12299-cit-0025","doi-asserted-by":"crossref","first-page":"5803","DOI":"10.1128\/JB.183.20.5803-5812.2001","article-title":"Analysis of a complete library of putative drug transporter genes in Escherichia coli","volume":"183","author":"Nishino","year":"2001","journal-title":"J Bacteriol"},{"key":"10.1111\/1574-6968.12299-BIB0026|fml12299-cit-0026","doi-asserted-by":"crossref","first-page":"1532","DOI":"10.1111\/j.1365-2958.2005.04769.x","article-title":"A dichotomous epigenetic mechanism governs expression of the LlaJI restriction\/modification system","volume":"57","author":"O'Driscoll","year":"2005","journal-title":"Mol Microbiol"},{"key":"10.1111\/1574-6968.12299-BIB0027|fml12299-cit-0027","doi-asserted-by":"crossref","first-page":"2039","DOI":"10.1128\/JB.01319-07","article-title":"Maintenance forced by a restriction-modification system can be modulated by a region in its modification enzyme not essential for methyltransferase activity","volume":"190","author":"Ohno","year":"2008","journal-title":"J Bacteriol"},{"key":"10.1111\/1574-6968.12299-BIB0028|fml12299-cit-0028","doi-asserted-by":"crossref","first-page":"32953","DOI":"10.1074\/jbc.M112.384321","article-title":"Reconstitution of the very short patch repair pathway from Escherichia coli","volume":"287","author":"Robertson","year":"2012","journal-title":"J Biol Chem"},{"key":"10.1111\/1574-6968.12299-BIB0030|fml12299-cit-0030","doi-asserted-by":"crossref","first-page":"1590","DOI":"10.1101\/gad.586710","article-title":"RNA methylation by Dnmt2 protects transfer RNAs against stress-induced cleavage","volume":"24","author":"Schaefer","year":"2010","journal-title":"Genes Dev"},{"key":"10.1111\/1574-6968.12299-BIB0031|fml12299-cit-0031","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1016\/j.bbrc.2005.07.051","article-title":"SMR proteins SugE and EmrE bind ligand with similar affinity and stoichiometry","volume":"335","author":"Sikora","year":"2005","journal-title":"Biochem Biophys Res Commun"},{"key":"10.1111\/1574-6968.12299-BIB0032|fml12299-cit-0032","doi-asserted-by":"crossref","first-page":"4214","DOI":"10.1128\/jb.172.8.4214-4221.1990","article-title":"A gene required for very short patch repair in Escherichia coli is adjacent to the DNA cytosine methylase gene","volume":"172","author":"Sohail","year":"1990","journal-title":"J Bacteriol"},{"key":"10.1111\/1574-6968.12299-BIB0033|fml12299-cit-0033","doi-asserted-by":"crossref","first-page":"5347","DOI":"10.1093\/nar\/22.24.5347","article-title":"Regulation of EcoRII methyltransferase: effect of mutations on gene expression and in vitro binding to the promoter region","volume":"22","author":"Som","year":"1994","journal-title":"Nucleic Acids Res"},{"key":"10.1111\/1574-6968.12299-BIB0034|fml12299-cit-0034","doi-asserted-by":"crossref","first-page":"914","DOI":"10.1016\/j.bbrc.2003.11.018","article-title":"Mutagenesis of SugE, a small multidrug resistance protein","volume":"312","author":"Son","year":"2003","journal-title":"Biochem Biophys Res Commun"},{"key":"10.1111\/1574-6968.12299-BIB0035|fml12299-cit-0035","doi-asserted-by":"crossref","first-page":"1126","DOI":"10.1128\/AAC.45.4.1126-1136.2001","article-title":"Antibiotic susceptibility profiles of Escherichia coli strains lacking multidrug efflux pump genes","volume":"45","author":"Sulavik","year":"2001","journal-title":"Antimicrob Agents Chemother"},{"key":"10.1111\/1574-6968.12299-BIB0036|fml12299-cit-0036","doi-asserted-by":"crossref","first-page":"6100","DOI":"10.1128\/JB.184.22.6100-6108.2002","article-title":"A DNA methyltransferase can protect the genome from postdisturbance attack by a restriction-modification gene complex","volume":"184","author":"Takahashi","year":"2002","journal-title":"J Bacteriol"},{"key":"10.1111\/1574-6968.12299-BIB0038|fml12299-cit-0038","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1038\/nprot.2007.521","article-title":"Agar and broth dilution methods to determine the minimal inhibitory concentration (MIC) of antimicrobial substances","volume":"3","author":"Wiegand","year":"2008","journal-title":"Nat Protoc"},{"key":"10.1111\/1574-6968.12299-BIB0039|fml12299-cit-0039","doi-asserted-by":"crossref","first-page":"916","DOI":"10.1126\/science.1186366","article-title":"Genome-wide evolutionary analysis of eukaryotic DNA methylation","volume":"328","author":"Zemach","year":"2010","journal-title":"Science"}],"container-title":["FEMS Microbiology Letters"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/femsle\/article-pdf\/350\/1\/100\/19128167\/350-1-100.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,3,10]],"date-time":"2022-03-10T17:42:38Z","timestamp":1646934158000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/femsle\/article-lookup\/doi\/10.1111\/1574-6968.12299"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,11,6]]},"references-count":35,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2014,1]]}},"URL":"https:\/\/doi.org\/10.1111\/1574-6968.12299","relation":{},"ISSN":["0378-1097"],"issn-type":[{"value":"0378-1097","type":"print"}],"subject":[],"published":{"date-parts":[[2013,11,6]]}}}