{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,27]],"date-time":"2026-10-27T04:23:31Z","timestamp":1793075011758,"version":"4.5.0"},"reference-count":30,"publisher":"Oxford University Press (OUP)","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["FEMS Microbiol Lett"],"published-print":{"date-parts":[[2014,9]]},"DOI":"10.1111\/1574-6968.12535","type":"journal-article","created":{"date-parts":[[2014,7,16]],"date-time":"2014-07-16T07:36:54Z","timestamp":1405496214000},"page":"64-71","source":"Crossref","is-referenced-by-count":22,"title":["Change in activity of serine palmitoyltransferase affects sensitivity to syringomycin E in yeast<i>Saccharomyces cerevisiae<\/i>"],"prefix":"10.1093","volume":"358","author":[{"given":"Moeko","family":"Toume","sequence":"first","affiliation":[{"name":"Department of Chemistry; Faculty of Sciences; Kyushu University; Higashi-ku Fukuoka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Motohiro","family":"Tani","sequence":"additional","affiliation":[{"name":"Department of Chemistry; Faculty of Sciences; Kyushu University; Higashi-ku Fukuoka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2014,7,29]]},"reference":[{"key":"10.1111\/1574-6968.12535-BIB0001|fml12535-cit-0001","doi-asserted-by":"crossref","first-page":"3254","DOI":"10.1073\/pnas.97.7.3254","article-title":"Lipid rafts function in biosynthetic delivery of proteins to the cell surface in yeast","volume":"97","author":"Bagnat","year":"2000","journal-title":"P Natl Acad Sci USA"},{"key":"10.1111\/1574-6968.12535-BIB0002|fml12535-cit-0002","doi-asserted-by":"crossref","first-page":"1127","DOI":"10.1002\/(SICI)1097-0061(19980915)14:12<1127::AID-YEA300>3.0.CO;2-#","article-title":"Functional analysis of yeast essential genes using a promoter-substitution cassette and the tetracycline-regulatable dual expression system","volume":"14","author":"Belli","year":"1998","journal-title":"Yeast"},{"key":"10.1111\/1574-6968.12535-BIB0003|fml12535-cit-0003","doi-asserted-by":"crossref","first-page":"266","DOI":"10.1128\/MMBR.63.2.266-292.1999","article-title":"Pseudomonas syringae phytotoxins: mode of action, regulation, and biosynthesis by peptide and polyketide synthetases","volume":"63","author":"Bender","year":"1999","journal-title":"Microbiol Mol Biol Rev"},{"key":"10.1111\/1574-6968.12535-BIB0004|fml12535-cit-0004","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1002\/(SICI)1097-0061(19980130)14:2<115::AID-YEA204>3.0.CO;2-2","article-title":"Designer deletion strains derived from Saccharomyces cerevisiae S288C: a useful set of strains and plasmids for PCR-mediated gene disruption and other applications","volume":"14","author":"Brachmann","year":"1998","journal-title":"Yeast"},{"key":"10.1111\/1574-6968.12535-BIB0005|fml12535-cit-0005","doi-asserted-by":"crossref","first-page":"1048","DOI":"10.1038\/nature08787","article-title":"Orm family proteins mediate sphingolipid homeostasis","volume":"463","author":"Breslow","year":"2010","journal-title":"Nature"},{"key":"10.1111\/1574-6968.12535-BIB0006|fml12535-cit-0006","doi-asserted-by":"crossref","first-page":"447","DOI":"10.1016\/j.plipres.2006.03.004","article-title":"Functions and metabolism of sphingolipids in Saccharomyces cerevisiae","volume":"45","author":"Dickson","year":"2006","journal-title":"Prog Lipid Res"},{"key":"10.1111\/1574-6968.12535-BIB0007|fml12535-cit-0007","doi-asserted-by":"crossref","first-page":"11062","DOI":"10.1074\/jbc.273.18.11062","article-title":"Syringomycin action gene SYR2 is essential for sphingolipid 4-hydroxylation in Saccharomyces cerevisiae","volume":"273","author":"Grilley","year":"1998","journal-title":"J Biol Chem"},{"key":"10.1111\/1574-6968.12535-BIB0008|fml12535-cit-0008","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1016\/S0014-5793(00)01821-4","article-title":"Requirement of sphingolipid alpha-hydroxylation for fungicidal action of syringomycin E","volume":"478","author":"Hama","year":"2000","journal-title":"FEBS Lett"},{"key":"10.1111\/1574-6968.12535-BIB0009|fml12535-cit-0009","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1016\/S0022-2275(20)39810-2","article-title":"The extraction of inositol-containing phospholipids and phosphatidylcholine from Saccharomyces cerevisiae and Neurospora crassa","volume":"21","author":"Hanson","year":"1980","journal-title":"J Lipid Res"},{"key":"10.1111\/1574-6968.12535-BIB0010|fml12535-cit-0010","doi-asserted-by":"crossref","first-page":"610","DOI":"10.1094\/MPMI-8-0610","article-title":"Role of biosurfactant and ion channel-forming activities of syringomycin in transmembrane ion flux: a model for the mechanism of action in the plant-pathogen interaction","volume":"8","author":"Hutchison","year":"1995","journal-title":"Mol Plant Microbe Interact"},{"key":"10.1111\/1574-6968.12535-BIB0011|fml12535-cit-0011","doi-asserted-by":"crossref","first-page":"272","DOI":"10.1016\/j.febslet.2004.05.074","article-title":"Sphingolipid C4 hydroxylation influences properties of yeast detergent-insoluble glycolipid-enriched membranes","volume":"569","author":"Idkowiak-Baldys","year":"2004","journal-title":"FEBS Lett"},{"key":"10.1111\/1574-6968.12535-BIB0012|fml12535-cit-0012","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1007\/s10719-013-9516-4","article-title":"GM3 and diabetes","volume":"31","author":"Inokuchi","year":"2014","journal-title":"Glycoconj J"},{"key":"10.1111\/1574-6968.12535-BIB0013|fml12535-cit-0013","doi-asserted-by":"crossref","first-page":"947","DOI":"10.1002\/yea.1142","article-title":"A versatile toolbox for PCR-based tagging of yeast genes: new fluorescent proteins, more markers and promoter substitution cassettes","volume":"21","author":"Janke","year":"2004","journal-title":"Yeast"},{"key":"10.1111\/1574-6968.12535-BIB0014|fml12535-cit-0014","doi-asserted-by":"crossref","first-page":"32566","DOI":"10.1074\/jbc.272.51.32566","article-title":"Involvement of yeast sphingolipids in the heat stress response of Saccharomyces cerevisiae","volume":"272","author":"Jenkins","year":"1997","journal-title":"J Biol Chem"},{"key":"10.1111\/1574-6968.12535-BIB0015|fml12535-cit-0015","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1007\/s10863-005-8645-2","article-title":"Sphingolipids influence the sensitivity of lipid bilayers to fungicide, syringomycin E","volume":"37","author":"Kaulin","year":"2005","journal-title":"J Bioenerg Biomembr"},{"key":"10.1111\/1574-6968.12535-BIB0016|fml12535-cit-0016","doi-asserted-by":"crossref","first-page":"11239","DOI":"10.1074\/jbc.M107756200","article-title":"Overexpression of ganglioside GM1 results in the dispersion of platelet-derived growth factor receptor from glycolipid-enriched microdomains and in the suppression of cell growth signals","volume":"277","author":"Mitsuda","year":"2002","journal-title":"J Biol Chem"},{"key":"10.1111\/1574-6968.12535-BIB0017|fml12535-cit-0017","doi-asserted-by":"crossref","first-page":"9809","DOI":"10.1074\/jbc.272.15.9809","article-title":"Sphingolipid synthesis as a target for antifungal drugs. Complementation of the inositol phosphorylceramide synthase defect in a mutant strain of Saccharomyces cerevisiae by the AUR1 gene","volume":"272","author":"Nagiec","year":"1997","journal-title":"J Biol Chem"},{"key":"10.1111\/1574-6968.12535-BIB0018|fml12535-cit-0018","doi-asserted-by":"crossref","first-page":"19222","DOI":"10.1073\/pnas.1116948108","article-title":"Protein kinase Ypk1 phosphorylates regulatory proteins Orm1 and Orm2 to control sphingolipid homeostasis in Saccharomyces cerevisiae","volume":"108","author":"Roelants","year":"2011","journal-title":"P Natl Acad Sci USA"},{"key":"10.1111\/1574-6968.12535-BIB0019|fml12535-cit-0019","doi-asserted-by":"crossref","first-page":"870","DOI":"10.1091\/mbc.E12-10-0753","article-title":"TORC1-regulated protein kinase Npr1 phosphorylates Orm to stimulate complex sphingolipid synthesis","volume":"24","author":"Shimobayashi","year":"2013","journal-title":"Mol Biol Cell"},{"key":"10.1111\/1574-6968.12535-BIB0020|fml12535-cit-0020","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1093\/genetics\/122.1.19","article-title":"A system of shuttle vectors and yeast host strains designed for efficient manipulation of DNA in Saccharomyces cerevisiae","volume":"122","author":"Sikorski","year":"1989","journal-title":"Genetics"},{"key":"10.1111\/1574-6968.12535-BIB0021|fml12535-cit-0021","doi-asserted-by":"crossref","first-page":"a004697","DOI":"10.1101\/cshperspect.a004697","article-title":"Membrane organization and lipid rafts","volume":"3","author":"Simons","year":"2011","journal-title":"Cold Spring Harb Perspect Biol"},{"key":"10.1111\/1574-6968.12535-BIB0022|fml12535-cit-0022","doi-asserted-by":"crossref","first-page":"2710","DOI":"10.1128\/AAC.40.12.2710","article-title":"In vitro antifungal and fungicidal activities and erythrocyte toxicities of cyclic lipodepsinonapeptides produced by Pseudomonas syringae pv. syringae","volume":"40","author":"Sorensen","year":"1996","journal-title":"Antimicrob Agents Chemother"},{"key":"10.1111\/1574-6968.12535-BIB0023|fml12535-cit-0023","doi-asserted-by":"crossref","first-page":"1174","DOI":"10.1128\/AAC.44.5.1174-1180.2000","article-title":"Syringomycin E inhibition of Saccharomyces cerevisiae: requirement for biosynthesis of sphingolipids with very-long-chain fatty acids and mannose- and phosphoinositol-containing head groups","volume":"44","author":"Stock","year":"2000","journal-title":"Antimicrob Agents Chemother"},{"issue":"Pt 2","key":"10.1111\/1574-6968.12535-BIB0024|fml12535-cit-0024","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1099\/13500872-140-2-353","article-title":"Identification and analysis of the Saccharomyces cerevisiae SYR1 gene reveals that ergosterol is involved in the action of syringomycin","volume":"140","author":"Taguchi","year":"1994","journal-title":"Microbiology"},{"key":"10.1111\/1574-6968.12535-BIB0025|fml12535-cit-0025","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1111\/j.1365-2958.2010.07340.x","article-title":"Requirement of a specific group of sphingolipid-metabolizing enzyme for growth of yeast Saccharomyces cerevisiae under impaired metabolism of glycerophospholipids","volume":"78","author":"Tani","year":"2010a","journal-title":"Mol Microbiol"},{"key":"10.1111\/1574-6968.12535-BIB0026|fml12535-cit-0026","doi-asserted-by":"crossref","first-page":"565","DOI":"10.1093\/jb\/mvq090","article-title":"Defect of synthesis of very long-chain fatty acids confers resistance to growth inhibition by inositol phosphorylceramide synthase repression in yeast Saccharomyces cerevisiae","volume":"148","author":"Tani","year":"2010b","journal-title":"J Biochem"},{"key":"10.1111\/1574-6968.12535-BIB0027|fml12535-cit-0027","doi-asserted-by":"crossref","first-page":"673","DOI":"10.1016\/j.bbrc.2011.11.138","article-title":"Hydroxylation state of fatty acid and long-chain base moieties of sphingolipid determine the sensitivity to growth inhibition due to AUR1 repression in Saccharomyces cerevisiae","volume":"417","author":"Tani","year":"2012","journal-title":"Biochem Biophys Res Commun"},{"key":"10.1111\/1574-6968.12535-BIB0028|fml12535-cit-0028","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1042\/BJ20051354","article-title":"Rescue of cell growth by sphingosine with disruption of lipid microdomain formation in Saccharomyces cerevisiae deficient in sphingolipid biosynthesis","volume":"394","author":"Tani","year":"2006","journal-title":"Biochem J"},{"key":"10.1111\/1574-6968.12535-BIB0029|fml12535-cit-0029","first-page":"171","article-title":"Synthetic genetic array analysis in Saccharomyces cerevisiae","volume":"313","author":"Tong","year":"2006","journal-title":"Methods Mol Biol"},{"key":"10.1111\/1574-6968.12535-BIB0030|fml12535-cit-0030","doi-asserted-by":"crossref","first-page":"47028","DOI":"10.1074\/jbc.M208257200","article-title":"Ganglioside induces caveolin-1 redistribution and interaction with the epidermal growth factor receptor","volume":"277","author":"Wang","year":"2002","journal-title":"J Biol Chem"}],"container-title":["FEMS Microbiology Letters"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/femsle\/article-pdf\/358\/1\/64\/19354236\/358-1-64.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,4,11]],"date-time":"2022-04-11T05:04:19Z","timestamp":1649653459000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/femsle\/article-lookup\/doi\/10.1111\/1574-6968.12535"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,7,29]]},"references-count":30,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2014,9]]}},"URL":"https:\/\/doi.org\/10.1111\/1574-6968.12535","relation":{},"ISSN":["0378-1097"],"issn-type":[{"value":"0378-1097","type":"print"}],"subject":[],"published":{"date-parts":[[2014,7,29]]}}}