{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,9]],"date-time":"2026-03-09T12:24:32Z","timestamp":1773059072037,"version":"3.50.1"},"reference-count":27,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2017,1,26]],"date-time":"2017-01-26T00:00:00Z","timestamp":1485388800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Emerg Medicine Australasia"],"published-print":{"date-parts":[[2017,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>To provide a current review of the clinical characteristics, predictors and outcomes in critically ill patients presenting to the <jats:styled-content style=\"fixed-case\">ED<\/jats:styled-content> with acute pancreatitis and subsequently admitted to an intensive care unit (<jats:styled-content style=\"fixed-case\">ICU<\/jats:styled-content>) of a tertiary referral centre in Australia.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A retrospective single\u2010centre study of adult patients admitted with pancreatitis. Severe acute pancreatitis defined by Bedside Index of Severity in Acute Pancreatitis (<jats:styled-content style=\"fixed-case\">BISAP<\/jats:styled-content>) score \u22652.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Eighty\u2010seven patients fulfilled criteria for inclusion during the study period, representing 0.9% of all <jats:styled-content style=\"fixed-case\">ICU<\/jats:styled-content> admissions. The median age of patients was 54. Survival was independent of patients\u2019 age, sex, aetiology and comorbidities. Mortality was 30.8% for both inpatient referrals to the <jats:styled-content style=\"fixed-case\">ICU<\/jats:styled-content> and for direct referrals via the ED. Higher mortality was identified among patients requiring mechanical ventilation (74.2 <jats:italic>vs<\/jats:italic> 24.6% in survivors; <jats:italic>P<\/jats:italic>\u2009&lt;\u20090.0001), vasopressor support (85.7 <jats:italic>vs<\/jats:italic> 33.8% in survivors; <jats:italic>P<\/jats:italic>\u2009&lt;\u20090.0001) or renal replacement therapy (60 <jats:italic>vs<\/jats:italic> 16.9% in survivors; <jats:italic>P<\/jats:italic>\u2009&lt;\u20090.002). <jats:styled-content style=\"fixed-case\">BISAP<\/jats:styled-content> score surpasses Ranson's and Acute Physiological and Chronic Health Examination (<jats:styled-content style=\"fixed-case\">APACHE<\/jats:styled-content>) <jats:styled-content style=\"fixed-case\">II<\/jats:styled-content> scores in discriminating between survivors and non\u2010survivors among unselected patients with acute pancreatitis admitted to <jats:styled-content style=\"fixed-case\">ICU<\/jats:styled-content>, whereas <jats:styled-content style=\"fixed-case\">APACHE II<\/jats:styled-content> discriminates better in the cohort admitted from <jats:styled-content style=\"fixed-case\">ED<\/jats:styled-content>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Severe acute pancreatitis is associated with high mortality. Aetiology and comorbidity did not predict adverse outcomes in this population. <jats:styled-content style=\"fixed-case\">BISAP<\/jats:styled-content> score is non\u2010inferior to <jats:styled-content style=\"fixed-case\">APACHE II<\/jats:styled-content> score as a prognostic tool in critically ill patients with acute pancreatitis and could be used to triage admission. Evidence of persistent organ dysfunction and requirements for organ support reliably identify patients at high\u2010risk of death.<\/jats:p><\/jats:sec>","DOI":"10.1111\/1742-6723.12737","type":"journal-article","created":{"date-parts":[[2017,1,26]],"date-time":"2017-01-26T23:43:34Z","timestamp":1485474214000},"page":"184-191","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Predictors and outcomes of acute pancreatitis in critically ill patients presenting to the emergency department of a tertiary referral centre in Australia"],"prefix":"10.1111","volume":"29","author":[{"given":"Krishnaswamy","family":"Sundararajan","sequence":"first","affiliation":[{"name":"Intensive Care Unit Royal Adelaide Hospital  Adelaide South Australia Australia"},{"name":"Discipline of Acute Care Medicine The University of Adelaide  Adelaide South Australia Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tom","family":"Schoeman","sequence":"additional","affiliation":[{"name":"Queen Elizabeth Hospital, Central Adelaide Local Health Network  Adelaide South Australia Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lara","family":"Hughes","sequence":"additional","affiliation":[{"name":"Flinders Medical Centre, Southern Adelaide Local Health Network  Adelaide South Australia Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Suzanne","family":"Edwards","sequence":"additional","affiliation":[{"name":"Data, Design and Statistics Service, Adelaide Health Technology Assessment, School of Public Health The University of Adelaide  Adelaide South Australia Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Benjamin","family":"Reddi","sequence":"additional","affiliation":[{"name":"Intensive Care Unit Royal Adelaide Hospital  Adelaide South Australia Australia"},{"name":"Discipline of Acute Care Medicine The University of Adelaide  Adelaide South Australia Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2017,1,26]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.dld.2011.08.011"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1097\/00006676-200407000-00062"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/s001340050808"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2012.08.002"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1136\/gut.2004.039883"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.CCM.0000148222.09869.92"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0016-5085(99)70192-7"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1038\/ajg.2009.622"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(14)60649-8"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1006\/jsre.2000.5925"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1038\/ajg.2013.218"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/bjs.1800771120"},{"key":"e_1_2_8_14_1","first-page":"358.e9","article-title":"Scoring systems in acute pancreatitis: which one to use in intensive care units?","volume":"252","author":"Juneja D","year":"2010","journal-title":"J. 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