{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T23:23:58Z","timestamp":1792797838965,"version":"4.5.0"},"reference-count":21,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2017,3,23]],"date-time":"2017-03-23T00:00:00Z","timestamp":1490227200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"The Prince Charles Hospital Foundation New Investigator Grant","award":["NI2015-119"],"award-info":[{"award-number":["NI2015-119"]}],"id":[{"id":"https:\/\/ror.org\/04kvjd760","id-type":"ROR","asserted-by":"crossref"}]},{"name":"Queensland Emergency Research Foundation Capacity Building Grant"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Emerg Medicine Australasia"],"published-print":{"date-parts":[[2017,4]]},"abstract":"Abstract<\/jats:title>\n \n Objective<\/jats:title>\n The objective was to examine the safety and efficacy of high\u2010flow nasal cannula (HFNC) therapy for children with bronchiolitis in a non\u2010tertiary paediatric setting.<\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n \n This was a single\u2010centre retrospective study conducted over 26 months (March 2013\u2013April 2015) on children aged 1\u201323 months with suspected bronchiolitis, who commenced on HFNC therapy in either the ED or the ward. Changes with respect to baseline data were analysed for effect on work of breathing (WOB), heart rate (HR) and respiratory rate (RR). Data was analysed using a linear mixed effects model and adjusted for age (\u226412 months and >12 months) and location (ED\n vs<\/jats:italic>\n ward). Transfer to a tertiary environment, escalation of care and adverse event rates were also recorded.\n <\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n A total of 61 children commenced on HFNC therapy, with flow rates ranging from 0.6 to 3.3L\/kg\/min. The proportion of patients with higher WOB scores appeared to reduce within 60 min of initiation of therapy. There was also a progressive reduction in surrogate markers of respiratory distress (HR and RR), with significant reductions evident by 60 min (\n P<\/jats:italic>\n < 0.05). There were no adverse events related to HFNC therapy. The transfer rate was 13%. It was predominantly due to lack of improvement of physiological parameters post initiation of HFNC therapy. None of the transferred patients required escalation of care.\n <\/jats:p>\n <\/jats:sec>\n \n Conclusion<\/jats:title>\n Within the limitations of this study it appears HFNC therapy may be safely commenced in both age groups in a non\u2010tertiary ED or ward, with an appropriate level of observation and robust transfer criteria.<\/jats:p>\n <\/jats:sec>","DOI":"10.1111\/1742-6723.12741","type":"journal-article","created":{"date-parts":[[2017,3,23]],"date-time":"2017-03-23T23:34:21Z","timestamp":1490312061000},"page":"198-203","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":20,"title":["Paediatric high\u2010flow nasal cannula therapy in children with bronchiolitis: A retrospective safety and efficacy study in a non\u2010tertiary environment"],"prefix":"10.1111","volume":"29","author":[{"given":"Michelle","family":"Davison","sequence":"first","affiliation":[{"name":"Department of Emergency Medicine and Children's Service The Prince Charles Hospital Brisbane Queensland Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mike","family":"Watson","sequence":"additional","affiliation":[{"name":"Department of Emergency Medicine and Children's Service The Prince Charles Hospital Brisbane Queensland Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leesa","family":"Wockner","sequence":"additional","affiliation":[{"name":"QIMR Berghofer Medical Research Institute Brisbane Queensland Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Frances","family":"Kinnear","sequence":"additional","affiliation":[{"name":"Department of Emergency Medicine and Children's Service The Prince Charles Hospital Brisbane Queensland Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2017,3,23]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.inf.0000053889.39392.a7"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00134-011-2177-5"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpeds.2009.10.039"},{"key":"e_1_2_8_5_1","first-page":"CD009609","article-title":"High\u2010flow nasal cannula therapy for infants with bronchiolitis","author":"Beggs S","year":"2014","journal-title":"Cochrane Database Syst. 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