{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,5]],"date-time":"2025-05-05T22:03:20Z","timestamp":1746482600636,"version":"3.37.3"},"reference-count":15,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2018,8,7]],"date-time":"2018-08-07T00:00:00Z","timestamp":1533600000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Emerg Medicine Australasia"],"published-print":{"date-parts":[[2018,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>Amiodarone is commonly used in the treatment of stable ventricular tachycardia (VT), but its efficacy has not been empirically examined in the prehospital setting. The objective of this study was to examine the safety and efficacy of amiodarone administered by paramedics to patients with stable VT.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Patient records from Victoria, Australia between 1 May 2007 and 30 June 2017 were examined retrospectively. Patients attended by Ambulance Victoria with stable sustained VT who were administered amiodarone by paramedics as the initial treatment were included. Data were used to determine the prevalence of treatment with amiodarone, the incidence of VT termination prior to transfer of care, and the incidence of progression to electrical cardioversion.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Sixty\u2010one patients were identified who met the inclusion criteria. The mean age was 72 years (standard deviation = 14) with 77% (<jats:italic>n<\/jats:italic> = 47) being male. Of the patients treated with amiodarone, 52% (<jats:italic>n<\/jats:italic> = 32) reverted successfully during paramedic care while 48% (<jats:italic>n<\/jats:italic> = 29) did not. Two patients required cardioversion for haemodynamic instability after amiodarone administration. One patient experienced cardiac arrest after receiving amiodarone and was successfully resuscitated by paramedics.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Approximately half of the patients treated with amiodarone reverted from VT while under paramedic care. Patient deterioration was rare, with cardiac arrest or requirement for cardioversion occurring very infrequently. Amiodarone was relatively safe and moderately effective for the treatment of sustained stable VT. However, given recent evidence of increased efficacy of procainamide for stable VT, further studies are required in the prehospital setting to compare these two drugs.<\/jats:p><\/jats:sec>","DOI":"10.1111\/1742-6723.13146","type":"journal-article","created":{"date-parts":[[2018,8,7]],"date-time":"2018-08-07T12:42:48Z","timestamp":1533645768000},"page":"694-698","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Amiodarone for sustained stable ventricular tachycardia in the prehospital setting"],"prefix":"10.1111","volume":"30","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7224-5005","authenticated-orcid":false,"given":"Christopher R","family":"Foerster","sequence":"first","affiliation":[{"name":"Tillsonburg District Memorial Hospital  Tillsonburg Ontario Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1579-9279","authenticated-orcid":false,"given":"Emily","family":"Andrew","sequence":"additional","affiliation":[{"name":"Ambulance Victoria  Melbourne Victoria Australia"},{"name":"Department of Epidemiology and Preventive Medicine Monash University  Melbourne Victoria Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9057-0685","authenticated-orcid":false,"given":"Karen","family":"Smith","sequence":"additional","affiliation":[{"name":"Ambulance Victoria  Melbourne Victoria Australia"},{"name":"Department of Epidemiology and Preventive Medicine Monash University  Melbourne Victoria Australia"},{"name":"School of Primary, Aboriginal and Rural Health Care The University of Western Australia  Perth Western Australia Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stephen","family":"Bernard","sequence":"additional","affiliation":[{"name":"Ambulance Victoria  Melbourne Victoria Australia"},{"name":"Department of Epidemiology and Preventive Medicine Monash University  Melbourne Victoria Australia"},{"name":"Alfred Hospital  Melbourne Victoria Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2018,8,7]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.110.970988"},{"key":"e_1_2_8_3_1","unstructured":"2011 Queensland Ambulance Service Broad complex tachycardia"},{"key":"e_1_2_8_4_1","unstructured":"Ambulance Victoria. GPC CPG A0404: ventricular tachycardia. Ambulance Victoria Clinical Practice Guidelines.2010."},{"key":"e_1_2_8_5_1","unstructured":"Australian Capitol Territory Ambulance. CMG 8 \u2013 tachycardias. ACT Ambulance Clinical Management Manual.2013."},{"key":"e_1_2_8_6_1","unstructured":"South Australia Ambulance Service. Ventricular tachycardia with pulse. SA Ambulance Service Clinical Practice Guidelines.2013."},{"key":"e_1_2_8_7_1","unstructured":"St John Ambulance Western Australia. Critical care guideline 6: tachycardia. St John WA Clinical Practice Guidelines.2013."},{"key":"e_1_2_8_8_1","unstructured":"Ambulance Tasmania. CPG A0403: ventricular tachycardia. Ambulance Tasmania Clinical Practice Guidelines.2012."},{"key":"e_1_2_8_9_1","unstructured":"St John Ambulance Northern Territory. Broad complex tachycardia. St John NT Clinical Practice Guidelines.2013."},{"key":"e_1_2_8_10_1","unstructured":"Ambulance Service of New South Wales. Protocol C8: dysrhythmias \u2013 tachycardia. NSW Ambulance Clinical Practice Guidelines.2014."},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1136\/hrt.62.5.367"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.annemergmed.2005.08.022"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1553-2712.2010.00680.x"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCOUTCOMES.114.001185"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1136\/emj.2007.051086"},{"key":"e_1_2_8_16_1","first-page":"1329","article-title":"Randomized comparison of intravenous procainamide vs. intravenous amiodarone for the acute treatment of tolerated wide QRS tachycardia: the PROCAMIO study","volume":"38","author":"Ortiz M","year":"2017","journal-title":"Eur. Heart J."}],"container-title":["Emergency Medicine Australasia"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2F1742-6723.13146","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/1742-6723.13146","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,17]],"date-time":"2023-09-17T16:04:38Z","timestamp":1694966678000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/1742-6723.13146"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,8,7]]},"references-count":15,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2018,10]]}},"alternative-id":["10.1111\/1742-6723.13146"],"URL":"https:\/\/doi.org\/10.1111\/1742-6723.13146","archive":["Portico"],"relation":{},"ISSN":["1742-6731","1742-6723"],"issn-type":[{"type":"print","value":"1742-6731"},{"type":"electronic","value":"1742-6723"}],"subject":[],"published":{"date-parts":[[2018,8,7]]},"assertion":[{"value":"2018-04-25","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-06-24","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-08-07","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}