{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,19]],"date-time":"2026-03-19T09:18:02Z","timestamp":1773911882551,"version":"3.50.1"},"reference-count":24,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2019,2,25]],"date-time":"2019-02-25T00:00:00Z","timestamp":1551052800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100004504","name":"Lietuvos Mokslo Taryba","doi-asserted-by":"publisher","award":["MIP\u2010049\/2015"],"award-info":[{"award-number":["MIP\u2010049\/2015"]}],"id":[{"id":"10.13039\/501100004504","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Emerg Medicine Australasia"],"published-print":{"date-parts":[[2019,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>Asthma exacerbations are common presentations to ED. Key guideline recommendations for management include administration of inhaled bronchodilators, systemic corticosteroids and titrated oxygen therapy. Our aim was to compare management and outcomes between patients treated for asthma in Europe (EUR) and South East Asia\/Australasia (SEA) and compliance with international guidelines.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>In each region, prospective, interrupted time series studies were performed including adult (age\u2009&gt;18 years) patients presenting to ED with the main complaint of dyspnoea during three 72 h periods. This was a planned sub\u2010study that included those with an ED primary diagnosis of asthma. Data was collected on demographics, clinical features, treatment in ED, diagnosis, disposition and in\u2010hospital outcome. The results of interest were differences in treatment and outcome between EUR and SEA cohorts.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Five hundred and eighty\u2010four patients were identified from 112 EDs (66 EUR and 46 SEA). The cohorts had similar demographics and co\u2010morbidity patterns, with 89% of the cohort having a previous diagnosis of asthma. There were no significant differences in treatment between EUR and SEA patients \u2013 inhaled beta\u2010agonists were administered in 86% of cases, systemic corticosteroids in 66%, oxygen therapy in 44% and antibiotics in 20%. Two thirds of patients were discharged home from the ED.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The data suggests that compliance with guideline\u2010recommended therapy in both regions, particularly corticosteroid administration, is sub\u2010optimal. It also suggests over\u2010use of antibiotics.<\/jats:p><\/jats:sec>","DOI":"10.1111\/1742-6723.13242","type":"journal-article","created":{"date-parts":[[2019,2,26]],"date-time":"2019-02-26T07:07:45Z","timestamp":1551164865000},"page":"756-762","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Treatment and outcome of adult patients with acute asthma in emergency departments in Australasia, South East Asia and Europe: Are guidelines followed? AANZDEM\/EuroDEM study"],"prefix":"10.1111","volume":"31","author":[{"given":"Simon","family":"Craig","sequence":"first","affiliation":[{"name":"Emergency Department Monash Medical Centre  Melbourne Victoria Australia"},{"name":"School of Clinical Sciences Monash Health, Monash University  Melbourne Victoria Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2134-7842","authenticated-orcid":false,"given":"Win Sen","family":"Kuan","sequence":"additional","affiliation":[{"name":"Emergency Medicine Department National University Health System  Singapore"},{"name":"Department of Surgery Yong Loo Lin School of Medicine, National University of Singapore  Singapore"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4655-5023","authenticated-orcid":false,"given":"Anne\u2010Maree","family":"Kelly","sequence":"additional","affiliation":[{"name":"Joseph Epstein Centre for Emergency Medicine Research Western Health  Melbourne Victoria Australia"},{"name":"Department of Medicine Melbourne Medical School \u2013 Western Precinct, The University of Melbourne  Melbourne Victoria Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Oene","family":"Van Meer","sequence":"additional","affiliation":[{"name":"Leiden University Medical Center  Leiden The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Justina","family":"Motiejunaite","sequence":"additional","affiliation":[{"name":"INSERM, U942, BIOmarkers in CArdioNeuroVAScular diseases  Paris France"},{"name":"Department of Anesthesiology and Critical Care APHP, Saint Louis Lariboisi\u00e8re Hospitals  Paris France"},{"name":"Department of Cardiology Lithuanian University of Health Sciences Kaunas Clinics  Kaunas Lithuania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gerben","family":"Keijzers","sequence":"additional","affiliation":[{"name":"Department of Emergency Medicine Gold Coast University Hospital  Brisbane Queensland Australia"},{"name":"Faculty of Health Sciences and Medicine Bond University  Brisbane Queensland Australia"},{"name":"School of Medicine Griffith University  Brisbane Queensland Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1560-1186","authenticated-orcid":false,"given":"Peter","family":"Jones","sequence":"additional","affiliation":[{"name":"Emergency Department Auckland City Hospital  Auckland New Zealand"},{"name":"Department of Surgery The University of Auckland  Auckland New Zealand"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Richard","family":"Body","sequence":"additional","affiliation":[{"name":"Emergency Medicine Central Manchester University Hospitals NHS Foundation Trust  Manchester UK"},{"name":"Division of Cardiovascular Sciences The University of Manchester  Manchester UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mehmet A","family":"Karamercan","sequence":"additional","affiliation":[{"name":"Emergency Medicine Department, Faculty of Medicine Gazi University  Ankara Turkey"},{"name":"Department of Emergency Medicine Istanbul Bagcilar Training and Research Hospital  Istanbul Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sharon","family":"Klim","sequence":"additional","affiliation":[{"name":"Joseph Epstein Centre for Emergency Medicine Research Western Health  Melbourne Victoria Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Veli\u2010Pekka","family":"Harjola","sequence":"additional","affiliation":[{"name":"Emergency Medicine University of Helsinki  Helsinki Finland"},{"name":"Department of Emergency Medicine and Services Helsinki University Hospital  Helsinki Finland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Franck","family":"Verschuren","sequence":"additional","affiliation":[{"name":"Department of Acute Medicine Universit\u00e9 Catholique de Louvain, Cliniques Universitaires Saint\u2010Luc  Brussels Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anna","family":"Holdgate","sequence":"additional","affiliation":[{"name":"Department of Emergency Medicine Liverpool Hospital  Sydney New South Wales Australia"},{"name":"Southwest Clinical School The University of New South Wales  Sydney New South Wales Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael","family":"Christ","sequence":"additional","affiliation":[{"name":"Emergency Department Luzerner Kantonsspital  Luzern Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Adela","family":"Golea","sequence":"additional","affiliation":[{"name":"Emergency Medicine, County Emergency Hospital Cluj\u2010Napoca University of Medicine and Pharmacy  Cluj\u2010Napoca Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Colin A","family":"Graham","sequence":"additional","affiliation":[{"name":"Emergency Medicine Chinese University of Hong Kong  Hong Kong"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jean","family":"Capsec","sequence":"additional","affiliation":[{"name":"Public Health Department Tours University Hospital  Tours France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cinzia","family":"Barletta","sequence":"additional","affiliation":[{"name":"Department of Emergency Medicine Santa Eugenio Hospital  Rome Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Luis","family":"Garcia\u2010Castrillo","sequence":"additional","affiliation":[{"name":"Servicio Urgencias Hospital Marqu\u00e9s de Valdecilla  Santander 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