{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,11]],"date-time":"2026-09-11T09:55:54Z","timestamp":1789120554995,"version":"build-2803163510"},"reference-count":21,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2020,7,24]],"date-time":"2020-07-24T00:00:00Z","timestamp":1595548800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Emerg Medicine Australasia"],"published-print":{"date-parts":[[2020,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>To test the administration of intravenous (i.v.) propofol at a procedural sedation dose compared to standard therapy for initial management of migraine in the ED.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This was an open label, randomised controlled pilot trial. Eligible patients were adults with a diagnosis of migraine and planned for treatment with i.v. medications. Patients were randomised to propofol or standard therapy groups. The primary outcome variable was time to discharge (TTD) defined as time from intervention to discharge from the ED. Secondary outcomes were safety of propofol administration and change in pain scores. A reduction of pain by \u226550% or discharge from the ED was defined as favourable. All analyses were performed on an intention\u2010to\u2010treat basis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Data from 29 patients were analysed, with 15 patients in the propofol group and 14 patients in the standard therapy group. TTD was significantly lower in the propofol group with median of 290 (interquartile range 162\u2013500) min compared to 554.5 (interquartile range 534\u2013639) min in the standard therapy group (<jats:italic>P<\/jats:italic>= 0.021). The hazard ratio for the defined favourable outcome of reduction of pain scores or discharge from the ED was 1.54 (95% CI 0.69\u20133.41).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Initial management of migraine with i.v. propofol at procedural sedation doses significantly reduced TTD compared to standard therapy. We did not detect any significant safety concerns although the study was not adequately powered to detect safety of the intervention and requires validation.<\/jats:p><\/jats:sec>","DOI":"10.1111\/1742-6723.13542","type":"journal-article","created":{"date-parts":[[2020,7,24]],"date-time":"2020-07-24T08:22:21Z","timestamp":1595578941000},"page":"542-547","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Propofol for migraine in the emergency department: A pilot randomised controlled trial"],"prefix":"10.1111","volume":"32","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0508-2450","authenticated-orcid":false,"given":"Biswadev","family":"Mitra","sequence":"first","affiliation":[{"name":"Emergency and Trauma Centre The Alfred Hospital Melbourne Victoria Australia"},{"name":"Department of Epidemiology and Preventive Medicine Monash University Melbourne Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6889-2338","authenticated-orcid":false,"given":"Cristina","family":"Roman","sequence":"additional","affiliation":[{"name":"Emergency and Trauma Centre The Alfred Hospital Melbourne Victoria Australia"},{"name":"Department of Pharmacy The Alfred Hospital Melbourne Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eric","family":"Mercier","sequence":"additional","affiliation":[{"name":"CHU de Qu\u00e9bec\u2010Universit\u00e9 Laval Research Center Population Health and Optimal Health Practices Axis, Universit\u00e9 Laval Quebec Quebec Canada"},{"name":"D\u00e9partement de M\u00e9decine Familiale et M\u00e9decine d'Urgence, Facult\u00e9 de M\u00e9decine Universit\u00e9 Laval Quebec Quebec Canada"},{"name":"Centre de recherche sur les soins et les services de premi\u00e8re ligne de l'Universit\u00e9 Laval Quebec Quebec Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1720-3037","authenticated-orcid":false,"given":"John","family":"Moloney","sequence":"additional","affiliation":[{"name":"Department of Anaesthesiology and Perioperative Medicine The Alfred Hospital Melbourne Victoria Australia"},{"name":"Department of Community Emergency Health and Paramedic Practice Monash University Melbourne Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gary","family":"Yip","sequence":"additional","affiliation":[{"name":"Department of Neurology The Alfred Hospital Melbourne Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Keshav","family":"Khullar","sequence":"additional","affiliation":[{"name":"Emergency and Trauma Centre The Alfred Hospital Melbourne Victoria 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