{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,14]],"date-time":"2025-05-14T00:27:48Z","timestamp":1747182468295,"version":"3.40.5"},"reference-count":13,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2020,8,3]],"date-time":"2020-08-03T00:00:00Z","timestamp":1596412800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001078","name":"Emergency Medicine Foundation","doi-asserted-by":"publisher","award":["EMPJ\u2010108R21\u20102014"],"award-info":[{"award-number":["EMPJ\u2010108R21\u20102014"]}],"id":[{"id":"10.13039\/501100001078","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Emerg Medicine Australasia"],"published-print":{"date-parts":[[2021,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>Lower respiratory tract infection (LRTI) is a frequent cause of dyspnoea in EDs, and is associated with considerable morbidity and mortality. We described and compared the management of this disease in Europe and Oceania\/South\u2010East Asia (SEA) cohorts.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We conducted a prospective cohort study with three time points in Europe and Oceania\/SEA. We included in this manuscript patients presenting to EDs with dyspnoea and a diagnosis of LRTI in ED. We collected comorbidities, chronic medication, clinical signs at arrival, laboratory parameters, ED management and patient outcomes.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 1389 patients were included, 773 in Europe and 616 in SEA. The European cohort had more comorbidities including chronic heart failure, obesity, chronic obstructive pulmonary disease and smoking. Levels of inflammatory markers were higher in Europe. There were more patients with inflammatory markers in Europe and more hypercapnia in Oceania\/SEA. The use of antibiotics was higher in SEA (72.2% <jats:italic>vs<\/jats:italic> 61.8%, <jats:italic>P<\/jats:italic>\u2009&lt;\u20090.001) whereas intravenous diuretics, non\u2010invasive and invasive ventilation were higher in Europe. Intensive care unit admission rate was 9.9% in Europe cohort and 3.4% in Oceania\/SEA cohort. ED mortality was 1% and overall in\u2010hospital mortality was 8.7% with no differences between regions.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>More patients with LRTI in Europe presented with cardio\u2010respiratory comorbidities, they received more adjunct therapies and had a higher intensive care unit admission rate than patients from Oceania\/SEA, although mortality was similar between the two cohorts.<\/jats:p><\/jats:sec>","DOI":"10.1111\/1742-6723.13567","type":"journal-article","created":{"date-parts":[[2020,8,4]],"date-time":"2020-08-04T00:28:03Z","timestamp":1596500883000},"page":"58-66","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Epidemiology, treatment and outcome of patients with lower respiratory tract infection presenting to emergency departments with dyspnoea (<scp>AANZDEM<\/scp> and <scp>EuroDEM<\/scp> studies)"],"prefix":"10.1111","volume":"33","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9893-1097","authenticated-orcid":false,"given":"Geoffroy","family":"Rousseau","sequence":"first","affiliation":[{"name":"Department of Emergency Medicine Tours University Hospital  Tours France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1100-4552","authenticated-orcid":false,"given":"Gerben","family":"Keijzers","sequence":"additional","affiliation":[{"name":"Department of Emergency Medicine Gold Coast University Hospital  Gold Coast Queensland Australia"},{"name":"School of Medicine Bond University  Gold Coast Queensland Australia"},{"name":"School of Medicine Griffith University  Gold Coast Queensland Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Oene","family":"van Meer","sequence":"additional","affiliation":[{"name":"Emergency Department Leiden University Medical Center  Leiden The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Simon","family":"Craig","sequence":"additional","affiliation":[{"name":"Emergency Department Monash Medical Centre  Melbourne Victoria Australia"},{"name":"School of Clinical Sciences, Monash Health Monash University  Melbourne Victoria Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mehmet","family":"Karamercan","sequence":"additional","affiliation":[{"name":"Department of Emergency Medicine, Faculty of Medicine Gazi University  Ankara Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sharon","family":"Klim","sequence":"additional","affiliation":[{"name":"Joseph Epstein Centre for Emergency Medicine Research Western Health  Melbourne Victoria Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Richard","family":"Body","sequence":"additional","affiliation":[{"name":"Emergency Medicine Central Manchester University Hospitals NHS Foundation Trust  Manchester UK"},{"name":"Division of Cardiovascular Sciences The University of Manchester  Manchester UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2134-7842","authenticated-orcid":false,"given":"Win Sen","family":"Kuan","sequence":"additional","affiliation":[{"name":"Department of Emergency Medicine National University Health System  Singapore"},{"name":"Department of Surgery, Yong Loo Lin School of Medicine National University of Singapore  Singapore"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Veli\u2010Pekka","family":"Harjola","sequence":"additional","affiliation":[{"name":"Emergency Medicine University of Helsinki  Helsinki Finland"},{"name":"Department of Emergency Medicine and Services Helsinki University Hospital  Helsinki Finland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1560-1186","authenticated-orcid":false,"given":"Peter","family":"Jones","sequence":"additional","affiliation":[{"name":"Emergency Department Auckland City Hospital  Auckland New Zealand"},{"name":"Department of Surgery The University of Auckland  Auckland New Zealand"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Franck","family":"Verschuren","sequence":"additional","affiliation":[{"name":"Department of Acute Medicine, Universit\u00e9 Catholique de Louvain Cliniques Universitaires Saint\u2010Luc  Brussels Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anna","family":"Holdgate","sequence":"additional","affiliation":[{"name":"Department of Emergency Medicine Liverpool Hospital  Sydney New South Wales Australia"},{"name":"Southwest Clinical School The University of New South Wales  Sydney New South Wales Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael","family":"Christ","sequence":"additional","affiliation":[{"name":"Emergency Department Luzerner Kantonsspital  Luzern Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Adela","family":"Golea","sequence":"additional","affiliation":[{"name":"Emergency Medicine, County Emergency Hospital Cluj\u2010Napoca University of Medicine and Pharmacy  Cluj\u2010Napoca Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jean","family":"Capsec","sequence":"additional","affiliation":[{"name":"Department of Public Health Tours University Hospital  Tours France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cinzia","family":"Barletta","sequence":"additional","affiliation":[{"name":"Department of Emergency Medicine Santa Eugenio Hospital  Rome Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Colin A","family":"Graham","sequence":"additional","affiliation":[{"name":"Emergency Medicine Chinese University of Hong Kong  Hong Kong"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Luis","family":"Garcia\u2010Castrillo","sequence":"additional","affiliation":[{"name":"Servicio Urgencias Hospital Marqu\u00e9s de Valdecilla  Santander Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Said","family":"Laribi","sequence":"additional","affiliation":[{"name":"Department of Emergency Medicine Tours University Hospital  Tours France"},{"name":"School of Medicine Tours University  Tours France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4655-5023","authenticated-orcid":false,"given":"Anne\u2010Maree","family":"Kelly","sequence":"additional","affiliation":[{"name":"Joseph Epstein Centre for Emergency Medicine Research Western Health  Melbourne Victoria Australia"},{"name":"Department of Medicine, Melbourne 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Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2020,8,3]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/acem.13118"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm.163.7.at1010"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469-0691.2011.03672.x"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1080\/1120009X.2017.1291467"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmi.2018.02.004"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1086\/425615"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/1742-6723.12397"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1097\/MEJ.0000000000000571"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1093\/ageing\/aft121"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/ijcp.12538"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1086\/321808"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1378\/chest.118.5.1344"},{"volume-title":"Therapeutic 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