{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,9]],"date-time":"2026-03-09T07:56:59Z","timestamp":1773043019659,"version":"3.50.1"},"reference-count":30,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2021,1,6]],"date-time":"2021-01-06T00:00:00Z","timestamp":1609891200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100000925","name":"National Health and Medical Research Council","doi-asserted-by":"publisher","award":["1139686"],"award-info":[{"award-number":["1139686"]}],"id":[{"id":"10.13039\/501100000925","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000925","name":"National Health and Medical Research Council","doi-asserted-by":"publisher","award":["1142691"],"award-info":[{"award-number":["1142691"]}],"id":[{"id":"10.13039\/501100000925","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000925","name":"National Health and Medical Research Council","doi-asserted-by":"publisher","award":["1159907"],"award-info":[{"award-number":["1159907"]}],"id":[{"id":"10.13039\/501100000925","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Emerg Medicine Australasia"],"published-print":{"date-parts":[[2021,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>The aim of the present study was to describe the epidemiology and clinical features of patients presenting to the ED with suspected and confirmed COVID\u201019 during Australia's \u2018second wave\u2019.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The COVID\u201019 ED (COVED) Project is an ongoing prospective cohort study in Australian EDs. This analysis presents data from 12 sites across four Australian states for the period from 1 July to 31 August 2020. All adult patients who met the criteria for \u2018suspected COVID\u201019\u2019 and underwent testing for SARS\u2010CoV\u20102 in the ED were eligible for inclusion. Study outcomes included a positive SARS\u2010CoV\u20102 test result, mechanical ventilation and in\u2010hospital mortality.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>There were 106\u2009136 presentations to the participating EDs and 12\u2009055 (11.4%; 95% confidence interval [CI] 11.2\u201311.6) underwent testing for SARS\u2010CoV\u20102. Of these, 255 (2%) patients returned a positive result. Among positive cases, 13 (5%) received mechanical ventilation during their hospital admission compared to 122 (2%) of the SARS\u2010CoV\u20102 negative patients (odds ratio 2.7; 95% CI 1.5\u20134.9, <jats:italic>P<\/jats:italic> = 0.001). Nineteen (7%) SARS\u2010CoV\u20102 positive patients died in hospital compared to 212 (3%) of the SARS\u2010CoV\u20102 negative patients (odds ratio 2.3; 95% CI 1.4\u20133.7, <jats:italic>P<\/jats:italic> = 0.001). Strong clinical predictors of the SARS\u2010CoV\u20102 test result included self\u2010reported fever, sore throat, bilateral infiltrates on chest X\u2010ray, and absence of a leucocytosis on first ED blood tests (<jats:italic>P<\/jats:italic> &lt;\u20090.05).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>In this prospective multi\u2010site study during Australia's \u2018second wave\u2019, a substantial proportion of ED presentations required SARS\u2010CoV\u20102 testing and isolation. Presence of SARS\u2010CoV\u20102 on nasopharyngeal swab was associated with an increase in the odds of death and mechanical ventilation in hospital.<\/jats:p><\/jats:sec>","DOI":"10.1111\/1742-6723.13706","type":"journal-article","created":{"date-parts":[[2020,12,14]],"date-time":"2020-12-14T21:43:16Z","timestamp":1607982196000},"page":"331-342","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Epidemiology and clinical features of emergency department patients with suspected <scp>COVID<\/scp>\u201019: Insights from Australia's \u2018second wave\u2019 (<scp>COVED<\/scp>\u20104)"],"prefix":"10.1111","volume":"33","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5763-917X","authenticated-orcid":false,"given":"Gerard M","family":"O'Reilly","sequence":"first","affiliation":[{"name":"Emergency and Trauma Centre Alfred Health  Melbourne Victoria Australia"},{"name":"School of Public Health and Preventive Medicine Monash 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