{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T02:18:56Z","timestamp":1791512336912,"version":"4.3.4"},"reference-count":19,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2022,7,18]],"date-time":"2022-07-18T00:00:00Z","timestamp":1658102400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Emerg Medicine Australasia"],"published-print":{"date-parts":[[2022,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objectives<\/jats:title><jats:p>To describe the clinical characteristics and outcomes of Code Stroke activations in an ED and determine predictors of a final diagnosis of stroke or transient ischemic attack (TIA) diagnosis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This was a retrospective analysis of Code Stroke activations through an ED over 2\u2009years at a quaternary stroke referral centre. Stroke Registry data was used to identify cases with clinical information abstracted from electronic medical records. The primary outcome was a final diagnosis of acute stroke or TIA and the secondary outcome was access to reperfusion therapies (thrombolysis and or endovascular clot retrieval).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The study analysed data from 1354 Code Stroke patients in ED. Of all Code Strokes, 51% had a stroke or TIA diagnosis on discharge. Patient characteristics independently associated with increased risk of stroke were increasing age, pre\u2010arrival notification by ambulance, elevated BP or presence of weakness or speech impairment as the initial presenting symptoms. Dizziness\/vertigo\/vestibular neuritis were the most common alternative diagnoses. One hundred and thirty\u2010five patients (10%) underwent reperfusion therapy. Pre\u2010arrival notification by ambulance was associated with higher proportion of eventual stroke\/TIA diagnosis (68%<jats:italic>vs<\/jats:italic>46%,<jats:italic>P<\/jats:italic>\u00a0&lt;\u20090.001) and significantly lower door to CT and door to needle times for patients undergoing thrombolysis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>In a cohort of patients requiring Code Stroke activation in an ED, increased age, systolic blood pressure and weakness and speech impairment increased the risk of stroke. Prehospital notification was associated with lower door to needle times for patients undergoing thrombolysis.<\/jats:p><\/jats:sec>","DOI":"10.1111\/1742-6723.14032","type":"journal-article","created":{"date-parts":[[2022,7,19]],"date-time":"2022-07-19T01:04:17Z","timestamp":1658192657000},"page":"976-983","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Evaluating Stroke Code Activation Pathway in Emergency Departments study"],"prefix":"10.1111","volume":"34","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0141-3128","authenticated-orcid":false,"given":"Anja","family":"Ebker\u2010White","sequence":"first","affiliation":[{"name":"School of Medicine The University of Notre Dame Australia Sydney New South Wales Australia"},{"name":"Emergency Department Royal Prince Alfred Hospital Sydney New South Wales Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Dinh","sequence":"additional","affiliation":[{"name":"Emergency Department Royal Prince Alfred Hospital Sydney New South Wales Australia"},{"name":"RPA Green Light Institute for Emergency Care, Royal Prince Alfred Hospital, Sydney Local Health District Sydney New South Wales Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ian","family":"Paver","sequence":"additional","affiliation":[{"name":"Emergency Department Royal Prince Alfred Hospital Sydney New South Wales Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kendall","family":"Bein","sequence":"additional","affiliation":[{"name":"Emergency Department Royal Prince Alfred Hospital Sydney New South Wales Australia"},{"name":"RPA Green Light Institute for Emergency Care, Royal Prince Alfred Hospital, Sydney Local Health District Sydney New South Wales Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kylie","family":"Tastula","sequence":"additional","affiliation":[{"name":"Department of Neurology Royal Prince Alfred Hospital Sydney New South Wales Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Melina","family":"Gattellari","sequence":"additional","affiliation":[{"name":"Department of Neurology Royal Prince Alfred Hospital Sydney New South Wales Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John","family":"Worthington","sequence":"additional","affiliation":[{"name":"Department of Neurology Royal Prince Alfred Hospital Sydney New South Wales Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,7,18]]},"reference":[{"key":"e_1_2_8_2_1","unstructured":"Deloitte Access Economics.The economic impact of stroke in Australia. 2020. [Cited 13 Jan 2021.]Available from URL:https:\/\/www2.deloitte.com\/au\/en\/pages\/economics\/articles\/economic\u2010impact\u2010stroke\u2010australia.html"},{"key":"e_1_2_8_3_1","volume-title":"Australia's Health 2018 3.7 Stroke. 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