{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,26]],"date-time":"2026-06-26T20:32:33Z","timestamp":1782505953248,"version":"3.54.5"},"reference-count":19,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2022,7,3]],"date-time":"2022-07-03T00:00:00Z","timestamp":1656806400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Emerg Medicine Australasia"],"published-print":{"date-parts":[[2022,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objectives<\/jats:title><jats:p>The Australasian Resuscitation in Sepsis Evaluation (ARISE) study researched septic shock treatment within EDs. This study aims to evaluate whether: (i) conduct of the ARISE study was associated with changes in epidemiology and care for adults (\u226518\u2009years) admitted from EDs to ICUs with sepsis in Australia and New Zealand; and (ii) such changes differed among 45 ARISE trial hospitals compared with 120 non\u2010trial hospitals.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Retrospective study using interrupted time series analysis in three time periods; \u2018Pre\u2010ARISE\u2019 (January 1997 to December 2007), \u2018During ARISE\u2019 (January 2008 to May 2014) and \u2018Post\u2010ARISE\u2019 (June 2014 to December 2017) using data from the Australian and New Zealand Intensive Care Society Adult Patient Database.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Over 21\u2009years there were 54\u2009121 ICU admissions from the ED with sepsis; which increased from 8.1% to 16.4%; 54.6% male, median (interquartile range) age 66 (53\u201376) years. In the pre\u2010ARISE period, pre\u2010ICU ED length of stay (LOS) decreased in trial hospitals but increased in non\u2010trial hospitals (<jats:italic>P<\/jats:italic>\u00a0=\u20090.174). During the ARISE study, pre\u2010ICU ED LOS declined more in trial hospitals (<jats:italic>P<\/jats:italic>\u00a0=\u20090.039) as did the frequency of mechanical ventilation in the first 24\u2009h (<jats:italic>P<\/jats:italic>\u00a0=\u20090.003). However, ICU and hospital LOS, in\u2010hospital mortality and risk of death declined similarly in both trial and non\u2010trial hospitals.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Sepsis\u2010related admissions increased from 8.1% to 16.4%. During the ARISE study, there was more rapid ICU admission and decreased early ventilation. However, these changes were not sustained nor associated with decreased risk of death or duration of hospitalisation.<\/jats:p><\/jats:sec>","DOI":"10.1111\/1742-6723.14034","type":"journal-article","created":{"date-parts":[[2022,7,4]],"date-time":"2022-07-04T02:08:55Z","timestamp":1656900535000},"page":"995-1003","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Temporal changes in the epidemiology of sepsis\u2010related intensive care admissions from the emergency department in Australia and New Zealand"],"prefix":"10.1111","volume":"34","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6446-3595","authenticated-orcid":false,"given":"Daryl","family":"Jones","sequence":"first","affiliation":[{"name":"Intensive Care Unit Austin Health  Melbourne Victoria Australia"},{"name":"School of Public Health and Preventive Medicine, Monash University  Melbourne Victoria Australia"},{"name":"The University of Melbourne  Melbourne Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John","family":"Moran","sequence":"additional","affiliation":[{"name":"Department of Intensive Care Medicine The Queen Elizabeth Hospital  Adelaide South Australia Australia"},{"name":"School of Medicine The University of Adelaide  Adelaide South Australia Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6284-2022","authenticated-orcid":false,"given":"Andrew","family":"Udy","sequence":"additional","affiliation":[{"name":"Australian and New Zealand Intensive Care Research Centre, School of Public Health and Preventive Medicine Monash University  Melbourne Victoria Australia"},{"name":"Department of Intensive Care and Hyperbaric Medicine Alfred Health  Melbourne Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Pilcher","sequence":"additional","affiliation":[{"name":"Australian and New Zealand Intensive Care Research Centre, School of Public Health and Preventive Medicine Monash University  Melbourne Victoria Australia"},{"name":"Department of Intensive Care and Hyperbaric Medicine Alfred Health  Melbourne Victoria Australia"},{"name":"Australian and New Zealand Intensive Care Society Centre for Outcome and Resource Evaluation  Melbourne Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anthony","family":"Delaney","sequence":"additional","affiliation":[{"name":"Department of Intensive Care Medicine Royal North Shore Hospital  Sydney New South Wales Australia"},{"name":"Division of Critical Care The George Institute for Global Health  Sydney New South Wales Australia"},{"name":"Northern Clinical School, Sydney Medical School The University of Sydney  Sydney New South Wales Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6682-7973","authenticated-orcid":false,"given":"Sandra L","family":"Peake","sequence":"additional","affiliation":[{"name":"Department of Intensive Care Medicine The Queen Elizabeth Hospital  Adelaide South Australia Australia"},{"name":"School of Medicine The University of Adelaide  Adelaide South Australia Australia"},{"name":"Department of Critical Care Research, Faculty of Medicine, Nursing and Health Sciences Monash University  Melbourne Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"the ARISE\u2010TRIPS study investigators","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,7,3]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1097\/CCM.0b013e31827c09f8"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.7189\/jogh.01.010404"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2014.2637"},{"key":"e_1_2_9_5_1","volume-title":"Epidemiology of Sepsis in Australian Public Hospitals","author":"Li L","year":"2020"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2016.0288"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00134-017-4681-8"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa010307"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.3310\/hta19970"},{"key":"e_1_2_9_10_1","first-page":"386","article-title":"Protocol\u2010based care for early septic shock","volume":"371","author":"Angus DC","year":"2014","journal-title":"N. 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