{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,14]],"date-time":"2025-05-14T00:26:51Z","timestamp":1747182411181,"version":"3.40.5"},"reference-count":28,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2022,11,7]],"date-time":"2022-11-07T00:00:00Z","timestamp":1667779200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Emerg Medicine Australasia"],"published-print":{"date-parts":[[2023,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>Sex differences in patients presenting with out\u2010of\u2010hospital cardiac arrest (OHCA) and shockable rhythm might be associated with disparities in clinical outcomes.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We conducted a retrospective cohort study and compared characteristics and short\u2010term outcomes between male and female adult patients who presented with OHCA and shockable rhythm at two large metropolitan health services in Melbourne, Australia between the period of 2014\u20132018. Logistic regression was used to assess the effect of sex on clinical outcomes.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Of 212 patients, 166 (78%) were males and 46 (22%) were females. Both males and females presented with similar rates of ST\u2010elevation myocardial infarction (44% <jats:italic>vs<\/jats:italic> 36%, <jats:italic>P<\/jats:italic>\u00a0=\u20090.29), although males were more likely to have a history of coronary artery disease (32% <jats:italic>vs<\/jats:italic> 13%) and a final diagnosis of a cardiac cause for their OHCA (89% <jats:italic>vs<\/jats:italic> 72%), both <jats:italic>P<\/jats:italic>\u00a0=\u20090.01. Rates of coronary angiography (81% <jats:italic>vs<\/jats:italic> 71%, <jats:italic>P<\/jats:italic>\u00a0=\u20090.23) and percutaneous coronary intervention (51% <jats:italic>vs<\/jats:italic> 42%, <jats:italic>P<\/jats:italic>\u00a0=\u20090.37) were comparable among males and females. No differences in rates of in\u2010hospital mortality (38% <jats:italic>vs<\/jats:italic> 37%, <jats:italic>P<\/jats:italic>\u00a0=\u20090.90) and 30\u2010day major adverse cardiac and cerebrovascular events (composite of all\u2010cause mortality, myocardial infarction, coronary revascularization and nonfatal stroke) (39% <jats:italic>vs<\/jats:italic> 41%, <jats:italic>P<\/jats:italic>\u00a0=\u20090.79) were observed between males and females, respectively. Female sex was not associated with worse in\u2010hospital mortality when adjusted for other variables (odds ratio 0.66, 95% confidence interval 0.28\u20131.60, <jats:italic>P<\/jats:italic>\u00a0=\u20090.36).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Among patients presenting with OHCA and a shockable rhythm, baseline sex and sex differences were not associated with disparities in short\u2010term outcomes in contemporary systems of care.<\/jats:p><\/jats:sec>","DOI":"10.1111\/1742-6723.14117","type":"journal-article","created":{"date-parts":[[2022,11,8]],"date-time":"2022-11-08T02:24:44Z","timestamp":1667874284000},"page":"297-305","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Sex differences among patients presenting to hospital with out\u2010of\u2010hospital cardiac arrest and shockable rhythm"],"prefix":"10.1111","volume":"35","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6831-6939","authenticated-orcid":false,"given":"Felicia CS","family":"Ho","sequence":"first","affiliation":[{"name":"Department of Cardiology Western Health  Melbourne Victoria Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wayne C","family":"Zheng","sequence":"additional","affiliation":[{"name":"Department of Cardiology Alfred Health  Melbourne Victoria Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Samer","family":"Noaman","sequence":"additional","affiliation":[{"name":"Department of Cardiology Western Health  Melbourne Victoria Australia"},{"name":"Department of Cardiology Alfred Health  Melbourne Victoria Australia"},{"name":"Department of Medicine, Western Health, Melbourne Medical School The University of Melbourne  Melbourne Victoria Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Riley 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