{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,2]],"date-time":"2026-06-02T05:55:27Z","timestamp":1780379727391,"version":"3.54.1"},"reference-count":22,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2023,2,8]],"date-time":"2023-02-08T00:00:00Z","timestamp":1675814400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Emerg Medicine Australasia"],"published-print":{"date-parts":[[2023,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>A randomised single\u2010blind trial was undertaken in an adult ED population, comparing the effectiveness of droperidol 2.5\u00a0mg IV with ondansetron 8\u00a0mg IV for the treatment of nausea and vomiting.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Patients were randomly allocated to receive droperidol (<jats:italic>n<\/jats:italic>\u00a0=\u00a060) or ondansetron (<jats:italic>n<\/jats:italic>\u00a0=\u00a060). Patients rated their nausea severity on a Visual Analogue Scale (VAS) immediately before and 30\u2009min after drug administration. The primary outcome was of symptom improvement, defined by a VAS change \u2265\u22128\u2009mm 30\u2009min post\u2010treatment. Mean VAS change and percentage experiencing desired effect were secondary outcomes compared.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Of 120 study patients, 60 (50%) received droperidol or ondansetron. Symptom improvement occurred in 93% (56 of 60) and 87% (52 of 60), respectively (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.362). Mean VAS change was \u221238\u2009mm and \u221229\u2009mm, respectively (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.031). Percentage of patients indicating desired effect was 85% and 63%, respectively (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.006). Additional antiemetics were required for 16% and 37% of subjects, respectively (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.006).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>There was no statistically significant difference in the primary outcome of symptom improvement between droperidol and ondansetron. Secondary outcomes which favour droperidol warrant further exploration.<\/jats:p><\/jats:sec>","DOI":"10.1111\/1742-6723.14174","type":"journal-article","created":{"date-parts":[[2023,2,9]],"date-time":"2023-02-09T06:30:20Z","timestamp":1675924220000},"page":"605-611","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Droperidol <scp><i>versus<\/i><\/scp> ondansetron for nausea treatment within the emergency department"],"prefix":"10.1111","volume":"35","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2590-9881","authenticated-orcid":false,"given":"Lachlan","family":"Philpott","sequence":"first","affiliation":[{"name":"Faculty of Medicine and Health The University of New South Wales  Sydney New South Wales Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3073-8335","authenticated-orcid":false,"given":"Ellie","family":"Clemensen","sequence":"additional","affiliation":[{"name":"Faculty of Medicine and Health The University of New South Wales  Sydney New South Wales Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gabriel T","family":"Lau","sequence":"additional","affiliation":[{"name":"Faculty of Medicine and Health The University of New South Wales  Sydney New South Wales Australia"},{"name":"Emergency Department Port Macquarie Base Hospital  Port Macquarie New South Wales Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,2,8]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/1742-6723.12861"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.annemergmed.2018.01.016"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajem.2009.09.028"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1553-2712.2008.00060.x"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1742-6723.2011.01444.x"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1742-6723.2004.00588.x"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.annemergmed.2014.03.017"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1067\/mem.2000.108652"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/acem.13650"},{"key":"e_1_2_9_11_1","first-page":"1","article-title":"Randomized controlled trial of ondansetron vs. prochlorperazine in adults in the emergency department","volume":"12","author":"Patka J","year":"2011","journal-title":"West. 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