{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,14]],"date-time":"2025-05-14T00:27:10Z","timestamp":1747182430830,"version":"3.40.5"},"reference-count":30,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2023,7,9]],"date-time":"2023-07-09T00:00:00Z","timestamp":1688860800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Emerg Medicine Australasia"],"published-print":{"date-parts":[[2023,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objectives<\/jats:title><jats:p>To describe rotational thromboelastometry (ROTEM) values (FIBTEM A5, EXTEM A5 and EXTEM CT) across age groups and assess for a statistical trend; and to determine whether any trend in ROTEM values is affected by severity of injury and packed red blood cells (PRBC) requirement.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Retrospective observational study at a level 1 trauma centre in Queensland, Australia. A total of 1601 consecutive trauma patients presenting to the ED. ROTEM data described included FIBTEM A5, EXTEM A5 and EXTEM CT. These values are described by age group (\u226430\u2009years, 31\u201345\u2009years, 46\u201360\u2009years, 61\u201375\u2009years and &gt;75\u2009years), Injury Severity Score (ISS) category (&lt;12, \u226512, &lt;25 and \u226525) and number of PRBCs transfused in the first 24\u2009h of admission (0\u2009units, 1\u20134\u2009units, 5\u20139\u2009units and \u226510\u2009units).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The median age of participants was 37\u2009years (interquartile range [IQR] 25\u201354\u2009years), with 48.2% of patients had severe trauma (ISS\u2009&gt;12) and 13.2% receiving at least one unit of PRBC in the first 24\u2009h of admission. Median (IQR) values for FIBTEM A5, EXTEM A5 and EXTEM CT were 13\u2009mm (10\u201316\u2009mm), 45\u2009mm (40\u201349\u2009mm) and 62\u2009s (56\u201371\u2009s), respectively. A test for trend over progressive age groups showed an increase in FIBTEM A5 (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.001) and EXTEM A5 values (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.001) and a decrease in EXTEM CT values (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.001).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The present study demonstrated a pattern of increasing coagulability, as defined by ROTEM, with increasing age group in trauma patients, even among the severely injured. Further investigation is required to determine the clinical impact of these findings on both the ROTEM\u2010guided management and longitudinal outcomes of these patients and whether an age\u2010specific approach is beneficial.<\/jats:p><\/jats:sec>","DOI":"10.1111\/1742-6723.14277","type":"journal-article","created":{"date-parts":[[2023,7,10]],"date-time":"2023-07-10T00:09:25Z","timestamp":1688947765000},"page":"976-982","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Rotational thromboelastometry values across age groups in all trauma patients presenting to a level 1 trauma centre: An observational study"],"prefix":"10.1111","volume":"35","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6179-2775","authenticated-orcid":false,"given":"Jack","family":"Simpson","sequence":"first","affiliation":[{"name":"Department of Intensive Care Gold Coast University Hospital, Queensland Health  Gold Coast Queensland Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"James","family":"McCullough","sequence":"additional","affiliation":[{"name":"Department of Intensive Care Gold Coast University Hospital, Queensland Health  Gold Coast Queensland Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kerin","family":"Walters","sequence":"additional","affiliation":[{"name":"Department of Trauma Gold Coast University Hospital, Queensland Health  Gold Coast Queensland Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elizabeth","family":"Wake","sequence":"additional","affiliation":[{"name":"Department of Trauma Gold Coast University Hospital, Queensland Health  Gold Coast Queensland Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Debbie","family":"Ho","sequence":"additional","affiliation":[{"name":"Department of Trauma Gold Coast University Hospital, Queensland Health  Gold Coast Queensland Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Erick","family":"Chan","sequence":"additional","affiliation":[{"name":"Department of Trauma Gold Coast University Hospital, Queensland Health  Gold Coast Queensland Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0679-7455","authenticated-orcid":false,"given":"Don","family":"Campbell","sequence":"additional","affiliation":[{"name":"Department of Trauma Gold Coast University Hospital, Queensland Health  Gold Coast Queensland Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"James","family":"Winearls","sequence":"additional","affiliation":[{"name":"Department of Intensive Care Gold Coast University Hospital, Queensland Health  Gold Coast Queensland Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2023,7,9]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13054-019-2347-3"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1097\/ACO.0000000000000447"},{"key":"e_1_2_8_4_1","first-page":"12","article-title":"Acute traumatic coagulopathy: incidence, risk stratification and therapeutic options","volume":"1","author":"Maegele M","year":"2010","journal-title":"World J. 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