{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,14]],"date-time":"2025-05-14T00:27:26Z","timestamp":1747182446849,"version":"3.40.5"},"reference-count":22,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2024,2,20]],"date-time":"2024-02-20T00:00:00Z","timestamp":1708387200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100002632","name":"Hallym University","doi-asserted-by":"publisher","award":["HURF\u20102022\u201014"],"award-info":[{"award-number":["HURF\u20102022\u201014"]}],"id":[{"id":"10.13039\/501100002632","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Emerg Medicine Australasia"],"published-print":{"date-parts":[[2024,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>To compare the efficacy and safety of ketamine alone with those of ketamine\u2010dexmedetomidine combination for sedation during brain CT in paediatric patients with head injuries.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We retrospectively analysed the data of paediatric patients who underwent sedation for brain CT at the ED. We included patients aged 6\u2009months to 6\u2009years with American Society of Anesthesiologists physical status I or II. The sedative protocol involved the administration of intramuscular (IM) ketamine 3\u2009mg\/kg (K), ketamine 2\u2009mg\/kg with dexmedetomidine 1.5\u2009\u03bcg\/kg (KD) or ketamine 1.5\u2009mg\/kg with dexmedetomidine 1.5\u2009\u03bcg\/kg (low\u2010KD). The primary and secondary outcomes were sedation failure and adverse events, respectively.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>We included 77 patients; among them, 28, 23 and 26 were in the K, KD and low\u2010KD groups, respectively. In multivariable analysis, the combination groups (KD and low\u2010KD groups) were significantly associated with a lower possibility of sedation failure compared to the K group (adjusted odds ratio, 0.12; 95% confidence interval, 0.02\u20130.56). Moreover, there were no significant differences in adverse events between the groups, and the sedation\u2010related time variables also did not significantly differ among the three groups.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Our findings indicated that a combination of IM ketamine\u2010dexmedetomidine provides effective sedation for paediatric patients undergoing brain CT without significant adverse events. Further research is needed to investigate the potential benefits of using lower doses of ketamine in combination.<\/jats:p><\/jats:sec>","DOI":"10.1111\/1742-6723.14383","type":"journal-article","created":{"date-parts":[[2024,2,21]],"date-time":"2024-02-21T05:23:20Z","timestamp":1708493000000},"page":"443-449","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Efficacy and safety of ketamine alone and ketamine\u2010dexmedetomidine combination for sedation for brain computed tomography in paediatric patients with head injuries: A retrospective study"],"prefix":"10.1111","volume":"36","author":[{"given":"Jaeyeon","family":"Yoon","sequence":"first","affiliation":[{"name":"Department of Emergency Medicine Hallym University Dongtan Sacred Heart Hospital  Hwaseong\u2010si South Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ju Ok","family":"Park","sequence":"additional","affiliation":[{"name":"Department of Emergency Medicine Hallym University Dongtan Sacred Heart Hospital  Hwaseong\u2010si South Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hyeonyoung","family":"Song","sequence":"additional","affiliation":[{"name":"Data Center Hallym University Dongtan Sacred Heart Hospital  Hwaseong\u2010si South Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2487-8988","authenticated-orcid":false,"given":"Choung A","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Emergency Medicine Hallym University Dongtan Sacred Heart Hospital  Hwaseong\u2010si South Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Soon\u2010Joo","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Emergency Medicine Hallym University Dongtan Sacred Heart Hospital  Hwaseong\u2010si South 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