{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T02:51:11Z","timestamp":1789527071038,"version":"build-2803163510"},"reference-count":25,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2024,3,13]],"date-time":"2024-03-13T00:00:00Z","timestamp":1710288000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100002076","name":"Emergency Medicine Foundation","doi-asserted-by":"publisher","award":["EMJS\u2010384R35\u20102021\u2010NIGHTINGALE"],"award-info":[{"award-number":["EMJS\u2010384R35\u20102021\u2010NIGHTINGALE"]}],"id":[{"id":"10.13039\/100002076","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Emerg Medicine Australasia"],"published-print":{"date-parts":[[2024,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>There is substantial practice variation in the management of cellulitis with limited prospective studies describing the course of cellulitis after diagnosis. We aimed to describe the demographics, clinical features (erythema, warmth, swelling and pain), patient\u2010reported disease trajectory and medium\u2010term follow\u2010up for ED patients with cellulitis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Prospective observational cohort study of adults diagnosed with cellulitis in two EDs in Southeast Queensland, Australia. Patients with (peri)orbital cellulitis and abscess were excluded. Data were obtained from a baseline questionnaire, electronic medical records and follow\u2010up questionnaires at 3, 7 and 14\u2009days. Clinician adjudication of day 14 cellulitis cure was compared to patient assessment. Descriptive analyses were conducted.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Three\u2010hundred patients (mean age 50\u2009years, SD 19.9) with cellulitis were enrolled, predominantly affecting the lower limb (75%). Cellulitis features showed greatest improvement between enrolment and day 3. Clinical improvement continued gradually at days 7 and 14 with persistent skin erythema (41%) and swelling (37%) at day 14. Skin warmth was the feature most likely to be resolved at each time point. There was a discrepancy in clinician and patient assessment of cellulitis cure at day 14 (85.8% <jats:italic>vs.<\/jats:italic> 52.8% cured).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>A clinical response of cellulitis features can be expected at day 3 with ongoing slower improvement over time. Over one third of patients had erythema or swelling at day 14. Patients are less likely than clinicians to deem their cellulitis cured at day 14. Future research should include parallel patient and clinician evaluation of cellulitis to help develop clearer definitions of treatment failure and cure.<\/jats:p><\/jats:sec>","DOI":"10.1111\/1742-6723.14401","type":"journal-article","created":{"date-parts":[[2024,3,14]],"date-time":"2024-03-14T05:41:08Z","timestamp":1710394868000},"page":"579-588","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Cellulitis in the Emergency Department: A prospective cohort study with patient\u2010centred follow\u2010up"],"prefix":"10.1111","volume":"36","author":[{"given":"Rachael S","family":"Nightingale","sequence":"first","affiliation":[{"name":"Department of Emergency Medicine Gold Coast University Hospital  Southport Queensland Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nimai","family":"Etheridge","sequence":"additional","affiliation":[{"name":"Department of Emergency Medicine Cairns Hospital  Cairns Queensland Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8392-5612","authenticated-orcid":false,"given":"Amy L","family":"Sweeny","sequence":"additional","affiliation":[{"name":"Department of Emergency Medicine Gold Coast University Hospital  Southport Queensland Australia"},{"name":"Faculty of Health Sciences and Medicine Bond University  Gold Coast Queensland Australia"},{"name":"School of Medicine and Dentistry Menzies Health Institute Queensland, Griffith University  Southport Queensland Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Graham","family":"Smyth","sequence":"additional","affiliation":[{"name":"School of Medicine and Dentistry Menzies Health Institute Queensland, Griffith University  Southport Queensland Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William","family":"Dace","sequence":"additional","affiliation":[{"name":"Department of Emergency Medicine Gold Coast University Hospital  Southport Queensland Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard A.F.","family":"Pellatt","sequence":"additional","affiliation":[{"name":"Department of Emergency Medicine Gold Coast University Hospital  Southport Queensland Australia"},{"name":"Faculty of Health Sciences and Medicine Bond University  Gold Coast Queensland Australia"},{"name":"School of Medicine and Dentistry Menzies Health Institute Queensland, Griffith University  Southport Queensland Australia"},{"name":"LifeFlight Retrieval Medicine  Brisbane Queensland Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8579-445X","authenticated-orcid":false,"given":"Peter J","family":"Snelling","sequence":"additional","affiliation":[{"name":"Department of Emergency Medicine Gold Coast University Hospital  Southport Queensland Australia"},{"name":"Faculty of Health Sciences and Medicine Bond University  Gold Coast Queensland Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Krishan","family":"Yadav","sequence":"additional","affiliation":[{"name":"Department of Emergency Medicine University of Ottawa  Ontario Canada"},{"name":"Ottawa Hospital Research Institute  Ottawa Ontario Canada"},{"name":"School of Epidemiology and Public Health (SEPH), University of Ottawa  Ottawa Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1100-4552","authenticated-orcid":false,"given":"Gerben","family":"Keijzers","sequence":"additional","affiliation":[{"name":"Department of Emergency Medicine Gold Coast University Hospital  Southport Queensland Australia"},{"name":"Faculty of Health Sciences and Medicine Bond University  Gold Coast Queensland Australia"},{"name":"School of Medicine and Dentistry Menzies Health Institute Queensland, Griffith University  Southport Queensland Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,3,13]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2016.8825"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/iwj.14088"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.325.7369.864"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1093\/ofid\/ofz335"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmi.2019.09.019"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2017.5653"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1007\/s15010-022-01842-7"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1007\/s15010-019-01347-w"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjd.16235"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jclinepi.2007.11.008"},{"key":"e_1_2_8_12_1","unstructured":"The British Pain Society.Outcome Measures. [Cited January 2019.] Available from URL:https:\/\/www.britishpainsociety.org\/static\/uploads\/resources\/files\/Outcome_Measures_January_2019.pdf"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1001\/archinte.164.15.1669"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/ciw463"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.18773\/austprescr.2016.058"},{"key":"e_1_2_8_16_1","unstructured":"Therapeutic Guidelines Limited.Cellulitis and Erysipelas. [Cited 2019.]. Available from URL:https:\/\/tgldcdp.tg.org.au\/viewTopic?etgAccess=true&guidelinePage=Antibiotic&topicfile=cellulitis\u2010erysipelas"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.12968\/bjon.2007.16.Sup1.27089"},{"key":"e_1_2_8_18_1","unstructured":"U.S. Department of Health and Human Services Food and Drug Administration Centre for Drug Evaluation and Research (CDER).Guidance for Industry. Acute Bacterial Skin and Skin Structure Infections: Developing Drugs for Treatment. [Cited October 2013.] Available from URL:https:\/\/www.fda.gov\/media\/71052\/download"},{"key":"e_1_2_8_19_1","article-title":"Interventions for cellulitis and erysipelas","volume":"6","author":"Kilburn SA","year":"2010","journal-title":"Cochrane Database Syst. Rev."},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1111\/1742-6723.13383"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1093\/ofid\/ofaa244"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1053\/ajem.2001.28330"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1097\/MEJ.0000000000000245"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1136\/emj.2004.018143"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.1017\/s1481803500014342"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.1002\/jhm.12977"}],"container-title":["Emergency Medicine Australasia"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/1742-6723.14401","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,7,17]],"date-time":"2024-07-17T02:39:31Z","timestamp":1721183971000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/1742-6723.14401"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,3,13]]},"references-count":25,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2024,8]]}},"alternative-id":["10.1111\/1742-6723.14401"],"URL":"https:\/\/doi.org\/10.1111\/1742-6723.14401","archive":["Portico"],"relation":{},"ISSN":["1742-6731","1742-6723"],"issn-type":[{"value":"1742-6731","type":"print"},{"value":"1742-6723","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,3,13]]},"assertion":[{"value":"2023-11-28","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-02-27","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-03-13","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}