{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,19]],"date-time":"2026-08-19T18:10:09Z","timestamp":1787163009729,"version":"build-2736575974"},"reference-count":5,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2024,10,10]],"date-time":"2024-10-10T00:00:00Z","timestamp":1728518400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100000925","name":"National Health and Medical Research Council","doi-asserted-by":"publisher","award":["GNT2001107"],"award-info":[{"award-number":["GNT2001107"]}],"id":[{"id":"10.13039\/501100000925","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Emerg Medicine Australasia"],"published-print":{"date-parts":[[2025,2]]},"abstract":"Abstract<\/jats:title>\n \n Objective<\/jats:title>\n To highlight the detection of xylazine and nitrazolam in conjunction with benzimidazole opioids (nitazenes) and other novel benzodiazepines in a cluster of patients after putative heroin use.<\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n Deidentified clinical and analytical data were gathered from patients enrolled in the Emerging Drugs Network of Australia system.<\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n In December 2023, three adults presented to the ED with sedation following putative use of heroin. Toxicological analysis of blood samples identified xylazine, protonitazene, metonitazene, bromazolam and nitrazolam. Local health authorities subsequently issued an alert.<\/jats:p>\n <\/jats:sec>\n \n Conclusion<\/jats:title>\n This is the first signal of xylazine and nitrazolam use in Australia. These results demonstrate toxico\u2010surveillance programmes with analytical confirmation of drugs are invaluable in monitoring illicit drug use.<\/jats:p>\n <\/jats:sec>","DOI":"10.1111\/1742-6723.14512","type":"journal-article","created":{"date-parts":[[2024,10,10]],"date-time":"2024-10-10T22:25:00Z","timestamp":1728599100000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["A cluster of multi\u2010drug intoxications involving xylazine, benzimidazole opioids (nitazenes) and novel benzodiazepines in South Australia"],"prefix":"10.1111","volume":"37","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6242-4480","authenticated-orcid":false,"given":"Emma","family":"Partridge","sequence":"first","affiliation":[{"name":"Forensic Science SA (Toxicology) Adelaide South Australia Australia"},{"name":"College of Science and Engineering, Flinders University Bedford Park South Australia Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter","family":"Stockham","sequence":"additional","affiliation":[{"name":"Forensic Science SA (Toxicology) Adelaide South Australia Australia"},{"name":"College of Science and Engineering, Flinders University Bedford Park South Australia Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michaela","family":"Kenneally","sequence":"additional","affiliation":[{"name":"Forensic Science SA (Toxicology) Adelaide South Australia Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew","family":"Luong","sequence":"additional","affiliation":[{"name":"Forensic Science SA (Toxicology) Adelaide South Australia Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chris","family":"Kostakis","sequence":"additional","affiliation":[{"name":"Forensic Science SA (Toxicology) Adelaide South Australia Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sam","family":"Alfred","sequence":"additional","affiliation":[{"name":"Emergency Department Royal Adelaide Hospital Adelaide South Australia Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,10,10]]},"reference":[{"key":"e_1_2_7_2_1","article-title":"Old drugs and new challenges: a narrative review of Nitazenes","volume":"15","author":"Pergolizzi J","year":"2023","journal-title":"Cureus"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.3390\/ph14060560"},{"key":"e_1_2_7_4_1","article-title":"Xylazine in the opioid epidemic: a systematic review of case reports and clinical implications","volume":"15","author":"Ayub S","year":"2023","journal-title":"Cureus"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/1742-6723.13839"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/1742-6723.13752"}],"container-title":["Emergency Medicine Australasia"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/1742-6723.14512","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,3,11]],"date-time":"2025-03-11T19:24:17Z","timestamp":1741721057000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/1742-6723.14512"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,10,10]]},"references-count":5,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2025,2]]}},"alternative-id":["10.1111\/1742-6723.14512"],"URL":"https:\/\/doi.org\/10.1111\/1742-6723.14512","archive":["Portico"],"relation":{},"ISSN":["1742-6731","1742-6723"],"issn-type":[{"value":"1742-6731","type":"print"},{"value":"1742-6723","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,10,10]]},"assertion":[{"value":"2024-07-05","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-09-24","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-10-10","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e14512"}}