{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,2]],"date-time":"2026-09-02T01:15:37Z","timestamp":1788311737266,"version":"build-2803163510"},"reference-count":5,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2025,3,18]],"date-time":"2025-03-18T00:00:00Z","timestamp":1742256000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Emerg Medicine Australasia"],"published-print":{"date-parts":[[2025,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>To evaluate the feasibility of pre\u2010hospital blood culture (BC) collection and intravenous (IV) antibiotic administration in patients with suspected sepsis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>In this open\u2010label trial, BCs were collected in all participants, who were then randomised to ongoing care (control) or ongoing care plus 2\u2009g IV ceftriaxone (intervention). Time to antibiotic administration was the primary outcome.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Thirty\u2010five patients were enrolled and randomised (21 control, 14 intervention). BCs were obtained in 89% (<jats:italic>n<\/jats:italic>\u2009=\u200931\/35) and grew a pathogen in 42% (<jats:italic>n<\/jats:italic>\u2009=\u200913\/31). Intervention patients received antibiotics a median of 108 (95% CI 34 to 170) minutes earlier (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.01).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>BCs were successfully obtained by paramedics, and pre\u2010hospital IV ceftriaxone resulted in expedited antibiotic administration.<\/jats:p><jats:p>Clinical Trial Registration: ACTRN12618000199213.<\/jats:p><\/jats:sec>","DOI":"10.1111\/1742-6723.70027","type":"journal-article","created":{"date-parts":[[2025,3,18]],"date-time":"2025-03-18T08:03:58Z","timestamp":1742285038000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Blood culture collection and administration of intravenous ceftriaxone by paramedics in patients with suspected sepsis (the pass trial)"],"prefix":"10.1111","volume":"37","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5026-7278","authenticated-orcid":false,"given":"Daniel","family":"Cudini","sequence":"first","affiliation":[{"name":"Ambulance Victoria  Melbourne Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karen","family":"Smith","sequence":"additional","affiliation":[{"name":"School of Public Health and Preventive Medicine Monash University  Melbourne Victoria Australia"},{"name":"Department of Paramedicine Monash University  Melbourne Victoria Australia"},{"name":"Department of Research and Innovation Silverchain  Melbourne Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeffery","family":"Shao","sequence":"additional","affiliation":[{"name":"School of Public Health and Preventive Medicine Monash University  Melbourne Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephen","family":"Bernard","sequence":"additional","affiliation":[{"name":"Ambulance Victoria  Melbourne Victoria Australia"},{"name":"School of Public Health and Preventive Medicine Monash University  Melbourne Victoria Australia"},{"name":"Department of Intensive Care and Hyperbaric Medicine The Alfred  Melbourne Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel","family":"Okyere","sequence":"additional","affiliation":[{"name":"Ambulance Victoria  Melbourne Victoria Australia"},{"name":"School of Public Health and Preventive Medicine Monash University  Melbourne Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ziad","family":"Nehme","sequence":"additional","affiliation":[{"name":"Ambulance Victoria  Melbourne Victoria Australia"},{"name":"School of Public Health and Preventive Medicine Monash University  Melbourne Victoria Australia"},{"name":"Department of Paramedicine Monash University  Melbourne Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1579-9279","authenticated-orcid":false,"given":"Emily","family":"Nehme","sequence":"additional","affiliation":[{"name":"Ambulance Victoria  Melbourne Victoria Australia"},{"name":"School of Public Health and Preventive Medicine Monash University  Melbourne Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Anderson","sequence":"additional","affiliation":[{"name":"Ambulance Victoria  Melbourne Victoria Australia"},{"name":"Department of Paramedicine Monash University  Melbourne Victoria Australia"},{"name":"Department of Intensive Care and Hyperbaric Medicine The Alfred  Melbourne Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicole","family":"Magnuson","sequence":"additional","affiliation":[{"name":"Ambulance Victoria  Melbourne Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karin","family":"Thursky","sequence":"additional","affiliation":[{"name":"National Centre for Antimicrobial Stewardship, Department of Infectious Diseases University of Melbourne  Melbourne Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dhruv","family":"Mori","sequence":"additional","affiliation":[{"name":"Department of Emergency Medicine Bendigo Health  Bendigo Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"De Witt","family":"Oosthuizen","sequence":"additional","affiliation":[{"name":"Department of Emergency Medicine Northeast Health Wangaratta  Wangaratta Victoria Australia"},{"name":"University of Melbourne Medical School  Wangaratta Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6284-2022","authenticated-orcid":false,"given":"Andrew","family":"Udy","sequence":"additional","affiliation":[{"name":"Department of Intensive Care and Hyperbaric Medicine The Alfred  Melbourne Victoria Australia"},{"name":"Australian and New Zealand Intensive Care\u2010Research Centre Monash University  Melbourne Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,3,18]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(19)32989-7"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/1742-6723.14357"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1703058"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1097\/CCM.0000000000005357"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2016.0287"}],"container-title":["Emergency Medicine Australasia"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/1742-6723.70027","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,5,16]],"date-time":"2025-05-16T04:13:12Z","timestamp":1747368792000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/1742-6723.70027"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,3,18]]},"references-count":5,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2025,4]]}},"alternative-id":["10.1111\/1742-6723.70027"],"URL":"https:\/\/doi.org\/10.1111\/1742-6723.70027","archive":["Portico"],"relation":{},"ISSN":["1742-6731","1742-6723"],"issn-type":[{"value":"1742-6731","type":"print"},{"value":"1742-6723","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,3,18]]},"assertion":[{"value":"2024-12-03","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-03-02","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-03-18","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70027"}}