{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,30]],"date-time":"2026-06-30T10:46:03Z","timestamp":1782816363100,"version":"3.54.5"},"reference-count":21,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2026,6,7]],"date-time":"2026-06-07T00:00:00Z","timestamp":1780790400000},"content-version":"vor","delay-in-days":6,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100000925","name":"National Health and Medical Research Council","doi-asserted-by":"publisher","award":["GNT2001107"],"award-info":[{"award-number":["GNT2001107"]}],"id":[{"id":"10.13039\/501100000925","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001598","name":"Mental Health Commission","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001598","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100031198","name":"Department of Health, Government of Western Australia","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100031198","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Emerg Medicine Australasia"],"published-print":{"date-parts":[[2026,6]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>We describe analytically confirmed opioid\u2010related presentations to emergency departments (EDs) in Australia.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Presentations with analytically confirmed opioid exposure, between January 2021 and December 2024, were identified from the Emerging Drugs Network of Australia (EDNA) Clinical Registry. Demographic data, clinical features, outcomes, naloxone dosing, and analytical toxicology results were extracted.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Opioids were detected in 793 ED presentations. The majority were male (568, 71.6%) with a median age of 40\u2009years (Q1\u2013Q3: 30\u201348\u2009years). Patients were unwell (Australasian Triage Score 1 or 2\u2009=\u2009700, 88.3%). Suicidal intent was noted in 55 (6.9%) presentations. Mono\u2010opioid detections occurred in 550 (69.4%) presentations, most frequently heroin exposures (162, 29.5%). Novel opioids including nitazenes and U\u2010Class synthetic opioids were uncommon (21, 2.6%). Illicit co\u2010detections were common (547, 69.0%) especially with methylamphetamine (512, 64.6%), gamma\u2010hydroxybutyrate (108, 13.6%), and diazepam (341, 43%). Naloxone was used in 498 (62.8%) presentations: median dose 400\u2009\u03bcg (IQR: 200\u2013600\u2009\u03bcg). There was no difference in median naloxone dose for heroin (median 320\u2009\u03bcg) and novel opioids (median 500\u2009\u03bcg,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.25). Intubation was more likely to occur in patients with novel opioids compared to heroin (8\/21, 26\/162,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.020).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Heroin was the most common analytically confirmed illicit opioid detected among opioid\u2010related ED presentations. Novel opioids were uncommon with no difference in median naloxone dose used. There were higher intubation rates for novel opioids. Polydrug exposure is common, complicating the clinical picture. Increased awareness of the national Take Home Naloxone program, particularly by emergency physicians, is a key element of harm reduction.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/1742-6723.70284","type":"journal-article","created":{"date-parts":[[2026,6,8]],"date-time":"2026-06-08T06:02:31Z","timestamp":1780898551000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Analytically Confirmed Opioid Detections From the Emerging Drugs Network of Australia"],"prefix":"10.1111","volume":"38","author":[{"ORCID":"https:\/\/orcid.org\/0009-0008-1548-1464","authenticated-orcid":false,"given":"J.","family":"Soderstrom","sequence":"first","affiliation":[{"name":"Emergency Medicine, Royal Perth Hospital University of Western Australia  Perth Western Australia Australia"},{"name":"Centre for Clinical Research in Emergency Medicine Harry Perkins Institute of Medical Research  Nedlands Western Australia Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1868-153X","authenticated-orcid":false,"given":"C.","family":"Weber","sequence":"additional","affiliation":[{"name":"Centre for Clinical Research in Emergency Medicine Harry Perkins Institute of Medical Research  Perth Western Australia Australia"},{"name":"East Metropolitan Health Service  Perth Western Australia Australia"},{"name":"School of Population and Global Health The University of Western Australia  Perth Western Australia Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7423-2467","authenticated-orcid":false,"given":"S.","family":"Greene","sequence":"additional","affiliation":[{"name":"Victorian Poisons Information Centre, Austin Health  Heidelberg Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K.","family":"Isoardi","sequence":"additional","affiliation":[{"name":"Clinical Toxicology Unit, Princess Alexandra Hospital  Brisbane Queensland Australia"},{"name":"Faculty of Medicine University of Queensland  Brisbane Queensland Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2226-7887","authenticated-orcid":false,"given":"S.","family":"Alfred","sequence":"additional","affiliation":[{"name":"Royal Adelaide Hospital Emergency Department University of Adelaide Acute Care Medicine  Adelaide South Australia Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"V.","family":"Tran","sequence":"additional","affiliation":[{"name":"Emergency Department Royal Hobart Hospital  Hobart Tasmania Australia"},{"name":"Tasmanian School of Medicine University of Tasmania  Hobart Tasmania Australia"},{"name":"Tasmanian Emergency Medicine Research Institute  Hobart Tasmania 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