{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,30]],"date-time":"2026-06-30T10:46:29Z","timestamp":1782816389735,"version":"3.54.5"},"reference-count":17,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2026,6,10]],"date-time":"2026-06-10T00:00:00Z","timestamp":1781049600000},"content-version":"vor","delay-in-days":9,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Emerg Medicine Australasia"],"published-print":{"date-parts":[[2026,6]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>Droperidol is increasingly used for agitated behaviour in emergency settings, and whilst Acute Behavioural Disturbance (ABD) guidelines exist for the general population, the use in trauma patients is not defined. This study aimed to explore the frequency of droperidol use in undifferentiated trauma patients, document adverse events and alignment to the general ABD guideline.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A retrospective convenience sample of all adult patients between 1\/12\/21 and 1\/12\/23 who met trauma activation criteria and received droperidol either pre\u2010hospital or in the emergency department was analysed. Data including patient characteristics, adverse events and alignment with the state ABD guideline were analysed using descriptive means.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Over the three\u2010year study period, 87 patients met inclusion criteria, with most patients being of male sex, middle\u2010aged, and sustaining blunt trauma. Adverse events were common, with 9\/87 (10%) having hypoxia (sats\u2009&lt;\u200990%, oxygen applied), hypotension (SBP\u2009&lt;\u200990\u2009mmHg), or extrapyramidal symptoms (dystonia). Adverse events were more common with concurrent alcohol\/drug use (78%) or more than one sedative agent (67%). Thirteen patients required multiple sedative agents. Younger patients (&lt;\u200965\u2009years) were more likely to receive a sedative dose aligned with local and state ABD guidelines (OR 4.5, 95% CI 1.51\u201313.40).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Droperidol is used in undifferentiated trauma patients with ABD. Adverse events were common, and more frequent in patients who report concurrent alcohol or illicit drug use. Wide variation in dose and use of additional medications for sedation of this diverse group was identified in the study and supports the need for further research to define optimal strategies to avoid potentially preventable adverse events.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/1742-6723.70293","type":"journal-article","created":{"date-parts":[[2026,6,10]],"date-time":"2026-06-10T13:03:36Z","timestamp":1781096616000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Droperidol for the Management of the Undifferentiated and Agitated Trauma Patient"],"prefix":"10.1111","volume":"38","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5476-1791","authenticated-orcid":false,"given":"Frances","family":"Williamson","sequence":"first","affiliation":[{"name":"Trauma Service, Royal Brisbane and Women's Hospital  Brisbane Queensland Australia"},{"name":"Queensland Ambulance Service  Brisbane Queensland Australia"},{"name":"Faculty of Medicine University of Queensland  Brisbane Queensland Australia"},{"name":"Jamieson Trauma Institute, Metro North Hospital and Health Service  Brisbane Queensland Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claire","family":"Bertenshaw","sequence":"additional","affiliation":[{"name":"Queensland Ambulance Service  Brisbane Queensland Australia"},{"name":"Royal Brisbane and Women's Hospital  Brisbane Queensland Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shea","family":"Roffey","sequence":"additional","affiliation":[{"name":"Emergency and Trauma Centre, Royal Brisbane and Women's Hospital  Brisbane Queensland Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,6,10]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.annemergmed.2015.03.016"},{"key":"e_1_2_12_3_1","unstructured":"Queensland Health Guideline \u201cManagement of Patients With Acute Severe Behavioural Disturbance in ED. QH\u2010GDL\u2010438 \u201d2024 https:\/\/www.health.qld.gov.au\/__data\/assets\/pdf_file\/0031\/629491\/qh\u2010gdl\u2010438.pdf."},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.1080\/10903127.2018.1445329"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.annemergmed.2010.05.037"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajem.2022.01.011"},{"key":"e_1_2_12_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajem.2024.07.060"},{"key":"e_1_2_12_8_1","doi-asserted-by":"publisher","DOI":"10.1197\/aemj.9.12.1402"},{"key":"e_1_2_12_9_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamanetworkopen.2024.44465"},{"key":"e_1_2_12_10_1","doi-asserted-by":"publisher","DOI":"10.5811\/westjem.2011.9.6866"},{"key":"e_1_2_12_11_1","unstructured":"Australian Institute of Health and Welfare Report (AIHW) \u201cEmergency Department Presentations 2023\u20102024 Royal Brisbane and Women's Hospital \u201dhttps:\/\/www.aihw.gov.au\/hospitals\/topics\/emergency\u2010departments\/presentations."},{"key":"e_1_2_12_12_1","unstructured":"RBWH Trauma Registry \u201cAnalytics Dashboard \u201daccessed15 November 2025."},{"key":"e_1_2_12_13_1","unstructured":"Queensland Ambulance Service Clinical Practice Procedures \u201cBehavioural Disturbances\/Emergency Sedation\u2010 Acute Behavioural Disturbance. CPP_BD_ESAB_0525 \u201dhttps:\/\/www.ambulance.qld.gov.au\/__data\/assets\/pdf_file\/0015\/219210\/CPP_Emergency\u2010sedation\u2010acute\u2010behavioural\u2010disturbance.pdf."},{"key":"e_1_2_12_14_1","doi-asserted-by":"publisher","DOI":"10.1097\/JTN.0000000000000910"},{"key":"e_1_2_12_15_1","doi-asserted-by":"publisher","DOI":"10.1080\/026990500120736"},{"key":"e_1_2_12_16_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13054-020-03452-x"},{"key":"e_1_2_12_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/1753-6405.13303"},{"key":"e_1_2_12_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jemermed.2024.07.005"}],"container-title":["Emergency Medicine Australasia"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/1742-6723.70293","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/1742-6723.70293","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/1742-6723.70293","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,6,30]],"date-time":"2026-06-30T10:14:49Z","timestamp":1782814489000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/1742-6723.70293"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,6]]},"references-count":17,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2026,6]]}},"alternative-id":["10.1111\/1742-6723.70293"],"URL":"https:\/\/doi.org\/10.1111\/1742-6723.70293","archive":["Portico"],"relation":{},"ISSN":["1742-6731","1742-6723"],"issn-type":[{"value":"1742-6731","type":"print"},{"value":"1742-6723","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,6]]},"assertion":[{"value":"2025-12-31","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-05-18","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-06-10","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70293"}}