{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,28]],"date-time":"2026-10-28T14:32:14Z","timestamp":1793197934234,"version":"4.5.0"},"reference-count":17,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T00:00:00Z","timestamp":1790035200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T00:00:00Z","timestamp":1790035200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Emerg Medicine Australasia"],"published-print":{"date-parts":[[2026,10]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>Evaluate the diagnostic accuracy of an artificial intelligence (AI) model for identifying urgent computed tomography brain (CTB) findings in consecutive emergency department (ED) patients and estimate the proportion eligible for expedited disposition.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We retrospectively analysed 3424 consecutive non\u2010contrast CTB scans from adults presenting to a quaternary ED in 2024. The AI model (Harrison Enterprise CTB) classified each scan as \u201curgent\u201d or \u201cnon\u2010urgent.\u201d The reference standard was the index consultant radiologist report alone, classified independently by two emergency physicians with disagreements resolved by a blinded consultant radiologist tiebreak, all blinded to AI output. In a separate post hoc analysis, false negatives were re\u2010adjudicated by a single unblinded assessor with access to the medical record and any subsequent imaging.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Of 3424 scans, 253 (7.4%) had urgent findings on the reference standard. AI sensitivity was 85.4% (95% CI 80.0%\u201389.0%), specificity 69.1% (95% CI 67.0%\u201371.0%) and negative predictive value (NPV) 98.3% (95% CI 98.0%\u201399.0%). An\u00a0estimated\u00a064.0% of encounters were true negatives potentially eligible for expedited disposition. Of 37 false negatives, independent\u00a0adjudication reclassified 24 as non\u2010urgent, yielding a post hoc sensitivity of 94.3% and NPV of 99.4%. The 13 remaining cases were small or subtle findings. None of the 13 cases required urgent intervention during the index ED presentation.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>The AI model demonstrated high NPV for urgent CTB findings, with no false negative requiring urgent intervention during the index ED presentation. Preliminary results provide the safety rationale to proceed with a prospective trial aiming to incorporate this technology into ED workflows.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/1742-6723.70353","type":"journal-article","created":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T02:50:41Z","timestamp":1790131841000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Artificial Intelligence Triage of Urgent Versus Non\u2010Urgent\n                    <scp>CT<\/scp>\n                    Brain Findings to Support Expedited Emergency Department Disposition: A Retrospective Validation Study"],"prefix":"10.1111","volume":"38","author":[{"given":"Hassan K.","family":"Ahmad","sequence":"first","affiliation":[{"name":"RPA Green Light Institute, Sydney Local Health District  Sydney New South Wales Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu Xuan","family":"Kitzing","sequence":"additional","affiliation":[{"name":"Department of Radiology Royal Prince Alfred Hospital  Sydney New South Wales Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Victoria","family":"Bond","sequence":"additional","affiliation":[{"name":"RPA Virtual Hospital, Sydney Local Health District  Sydney New South Wales Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-5359-0461","authenticated-orcid":false,"given":"Jethro","family":"Worsam","sequence":"additional","affiliation":[{"name":"Sydney Medical School, Faculty of Medicine and Health, the University of Sydney  Sydney New South Wales Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alvin","family":"Tan","sequence":"additional","affiliation":[{"name":"Department of Radiology Royal Prince Alfred Hospital  Sydney New South Wales Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Oliver","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Radiology Royal Prince Alfred Hospital  Sydney New South Wales Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brindha","family":"Shivalingam","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery Chris O'brien Lifehouse  Sydney New South Wales Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3903-4801","authenticated-orcid":false,"given":"Radhika","family":"Seimon","sequence":"additional","affiliation":[{"name":"RPA Green Light Institute, Sydney Local Health District  Sydney New South Wales Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-6212-3898","authenticated-orcid":false,"given":"Eliot","family":"Salmon","sequence":"additional","affiliation":[{"name":"RPA Green Light Institute, Sydney Local Health District  Sydney New South Wales Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael M.","family":"Dinh","sequence":"additional","affiliation":[{"name":"RPA Green Light Institute, Sydney Local Health District  Sydney New South Wales Australia"},{"name":"Emergency Department Royal Prince Alfred Hospital, Sydney Local Health District  Sydney New South Wales Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,9,22]]},"reference":[{"key":"e_1_2_11_2_1","unstructured":"NSW Ministry of Health \u201cFuture Health: Guiding the Next Decade of Care in NSW 2022\u201332 \u201d2022 https:\/\/www.health.nsw.gov.au\/about\/nswhealth\/pages\/future\u2010health.aspx."},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmjopen\u20102020\u2010043315"},{"key":"e_1_2_11_4_1","unstructured":"Australian Institute of Health and Welfare \u201cInjury in Australia: Falls \u201d2025 https:\/\/www.aihw.gov.au\/reports\/injury\/falls."},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.3174\/ajnr.A6408"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.3390\/jcm14072377"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00062\u2010023\u201001291\u20101"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41746\u2010025\u201002244\u20103"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.3174\/ajnr.A8986"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1136\/emermed\u20102024\u2010214781"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.3348\/kjr.2022.0651"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41591\u2010025\u201003953\u20108"},{"key":"e_1_2_11_13_1","unstructured":"P. R.Brotchie \u201cUrgent vs Non\u2010Urgent Triage of CTB Based on a Comprehensive AI Model: Validation on a Ground\u2010Truthed Real\u2010World Dataset \u201d2023."},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00330\u2010023\u201010074\u20108"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1097\/TA.0000000000000161"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.1097\/TA.0000000000003554"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.1227\/01.NEU.0000210364.29290.C9"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.1161\/STR.0000000000000070"}],"container-title":["Emergency Medicine Australasia"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/1742-6723.70353","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/1742-6723.70353","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/1742-6723.70353","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,28]],"date-time":"2026-10-28T13:36:49Z","timestamp":1793194609000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/1742-6723.70353"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9,22]]},"references-count":17,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2026,10]]}},"alternative-id":["10.1111\/1742-6723.70353"],"URL":"https:\/\/doi.org\/10.1111\/1742-6723.70353","archive":["Portico"],"relation":{},"ISSN":["1742-6731","1742-6723"],"issn-type":[{"value":"1742-6731","type":"print"},{"value":"1742-6723","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,9,22]]},"assertion":[{"value":"2026-05-26","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-09-05","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-09-22","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70353"}}