{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,28]],"date-time":"2026-10-28T14:32:06Z","timestamp":1793197926115,"version":"4.5.0"},"reference-count":19,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T00:00:00Z","timestamp":1791417600000},"content-version":"vor","delay-in-days":7,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Emerg Medicine Australasia"],"published-print":{"date-parts":[[2026,10]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>Sepsis is a leading cause of critical illness in Australia and New Zealand, with over 75% of admissions occurring through emergency departments. This study aimed to characterise the demographics, process of care, pharmacology, and peri\u2010intubation adverse events of sepsis intubations using a prospective Australasian registry.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      A retrospective analysis of prospectively collected data from the Australian and New Zealand Emergency Department Airway Registry (ANZEDAR) was performed across 79 hospitals between January 2010 and March 2026. Intubations performed for a primary indication of sepsis were identified. A paediatric subgroup analysis was performed stratified by age band. Statistical comparisons used Mann\u2013Whitney\n                      <jats:italic>U<\/jats:italic>\n                      tests for continuous variables and chi\u2010square or Fisher's exact tests for categorical variables.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Of 11,289 registry intubations, 280 (2.5%) were performed for sepsis. Paediatric patients with confirmed age under 16\u2009years comprised 30 of 280 sepsis intubations (10.7%). Adults were older, more haemodynamically compromised, and had longer triage to intubation times than non\u2010sepsis patients across all age groups. Laryngoscopic views and first\u2010pass success were comparable between sepsis and non\u2010sepsis groups. Haemodynamic complications occurred in 27.9% of sepsis intubations and peri\u2010intubation cardiac arrest in 4.6%. Waveform capnography was used less frequently in sepsis versus non\u2010sepsis groups (87.5% vs. 94.1%;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Emergency department sepsis intubation is associated with high rates of haemodynamic complications despite similar laryngoscopic views and first\u2010pass success rates. Low waveform capnography use in infant sepsis represents a potential patient safety concern. These findings support targeted interventions.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/1742-6723.70362","type":"journal-article","created":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T09:04:02Z","timestamp":1791450242000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Characteristics, Practice Patterns, and Outcomes of Emergency Department Intubation for Sepsis: An\n                    <scp>ANZEDAR<\/scp>\n                    Registry Study"],"prefix":"10.1111","volume":"38","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5588-3061","authenticated-orcid":false,"given":"Pramod","family":"Chandru","sequence":"first","affiliation":[{"name":"Emergency Department Nepean Hospital  Sydney New South Wales Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5569-704X","authenticated-orcid":false,"given":"Hatem","family":"Alkhouri","sequence":"additional","affiliation":[{"name":"Agency for Clinical Innovation Emergency Care Institute  Sydney New South Wales Australia"},{"name":"Faculty of Medicine The University of Sydney  New South Wales Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2093-855X","authenticated-orcid":false,"given":"Toby","family":"Fogg","sequence":"additional","affiliation":[{"name":"Emergency Department Royal North Shore Hospital  Sydney New South Wales Australia"},{"name":"CareFlight  Sydney New South Wales Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0225-7953","authenticated-orcid":false,"given":"Elliot","family":"Long","sequence":"additional","affiliation":[{"name":"Royal Children's Hospital, Murdoch Children's Research Institute University of Melbourne  Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,10,8]]},"reference":[{"key":"e_1_2_13_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(19)32989-7"},{"key":"e_1_2_13_3_1","volume-title":"National Sepsis Program Extension Epidemiology Report","author":"Australian Commission on Safety and Quality in Health Care","year":"2025"},{"key":"e_1_2_13_4_1","doi-asserted-by":"publisher","DOI":"10.1097\/CCM.0000000000007075"},{"key":"e_1_2_13_5_1","doi-asserted-by":"publisher","DOI":"10.1097\/PCC.0000000000003927"},{"key":"e_1_2_13_6_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-024-73461-1"},{"key":"e_1_2_13_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcrc.2015.08.018"},{"key":"e_1_2_13_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bja.2017.10.021"},{"key":"e_1_2_13_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bjae.2020.09.004"},{"key":"e_1_2_13_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/1742-6723.13416"},{"key":"e_1_2_13_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/1742-6723.12815"},{"key":"e_1_2_13_12_1","unstructured":"The Jamovi Project \u201cjamovi (Version 2.6) [Computer Software] \u201d(2025) https:\/\/www.jamovi.org."},{"key":"e_1_2_13_13_1","doi-asserted-by":"publisher","DOI":"10.53391\/2146\u20104618.1039"},{"key":"e_1_2_13_14_1","doi-asserted-by":"publisher","DOI":"10.1097\/CCM.0b013e31825fec26"},{"key":"e_1_2_13_15_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13054-024-04831-4"},{"key":"e_1_2_13_16_1","doi-asserted-by":"publisher","DOI":"10.1378\/chest.14-1012"},{"key":"e_1_2_13_17_1","doi-asserted-by":"publisher","DOI":"10.1093\/bja\/aer058"},{"key":"e_1_2_13_18_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.110.970988"},{"issue":"1","key":"e_1_2_13_19_1","article-title":"Navigating Pediatric Capnography: A Comprehensive Review of Scope and Limitations","volume":"16","author":"Damam S.","year":"2024","journal-title":"Cureus"},{"key":"e_1_2_13_20_1","doi-asserted-by":"publisher","DOI":"10.1186\/1865-1380-5-31"}],"container-title":["Emergency Medicine Australasia"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/1742-6723.70362","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/1742-6723.70362","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/1742-6723.70362","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,28]],"date-time":"2026-10-28T13:36:00Z","timestamp":1793194560000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/1742-6723.70362"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,10]]},"references-count":19,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2026,10]]}},"alternative-id":["10.1111\/1742-6723.70362"],"URL":"https:\/\/doi.org\/10.1111\/1742-6723.70362","archive":["Portico"],"relation":{},"ISSN":["1742-6731","1742-6723"],"issn-type":[{"value":"1742-6731","type":"print"},{"value":"1742-6723","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,10]]},"assertion":[{"value":"2026-06-29","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-09-25","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-10-08","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70362"}}