{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T00:41:48Z","timestamp":1787013708789,"version":"build-2736575974"},"reference-count":23,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2020,8,21]],"date-time":"2020-08-21T00:00:00Z","timestamp":1597968000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["31830087"],"award-info":[{"award-number":["31830087"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81829004"],"award-info":[{"award-number":["81829004"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Insect Science"],"published-print":{"date-parts":[[2021,10]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Zika virus disease is caused by Zika virus infection, as transmitted by\n                    <jats:italic>Aedes<\/jats:italic>\n                    spp. mosquitoes. Many of the Zika virus strains isolated from patients display different pathogenicities toward humans. The vector mosquitoes for Zika virus are mainly of the\n                    <jats:italic>Aedes<\/jats:italic>\n                    genus, especially\n                    <jats:italic>Aedes aegypti<\/jats:italic>\n                    and\n                    <jats:italic>Aedes albopictus<\/jats:italic>\n                    . However, susceptibility and interactions between\n                    <jats:italic>Aedes<\/jats:italic>\n                    spp. mosquitoes and Zika viruses remain unclear. In this study, we chose two Zika virus strains (FSS13025 and PRVABC59) with different abilities to infect the primary vector mosquitoes\n                    <jats:italic>Ae. aegypti<\/jats:italic>\n                    and\n                    <jats:italic>Ae. albopictus<\/jats:italic>\n                    . The transcriptomes and small RNA profiles of infected and uninfected mosquitoes were comparatively analyzed, and differentially expressed genes were functionally examined using RNA interference. According to the results, the susceptibility of PRVABC59 was higher than that of FSS13025 in\n                    <jats:italic>Aedes<\/jats:italic>\n                    vector mosquitoes, and\n                    <jats:italic>Ae. aegypti<\/jats:italic>\n                    was more susceptible to Zika virus than was\n                    <jats:italic>Ae. albopictus<\/jats:italic>\n                    . For PRVABC59 infection, specific differential expression profiles correlated with\n                    <jats:italic>Ae. aegypti<\/jats:italic>\n                    and\n                    <jats:italic>Ae. albopictus<\/jats:italic>\n                    , and susceptibility was significantly affected when three targeted genes were successfully knocked down. Compared with PRVABC59, infection of\n                    <jats:italic>Ae. albopictus<\/jats:italic>\n                    with FSS13025 generated more 21\u2010nt virus small interference RNA. It can be concluded that the susceptibility of vector\n                    <jats:italic>Aedes<\/jats:italic>\n                    spp. mosquitoes to Zika viruses varies and that the interactions between mosquitoes and Zika virus correlate with susceptibility.\n                  <\/jats:p>","DOI":"10.1111\/1744-7917.12858","type":"journal-article","created":{"date-parts":[[2020,7,29]],"date-time":"2020-07-29T10:25:31Z","timestamp":1596018331000},"page":"1439-1451","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Susceptibility and interactions between\n                    <i>Aedes<\/i>\n                    mosquitoes and Zika viruses"],"prefix":"10.1111","volume":"28","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5512-6714","authenticated-orcid":false,"given":"Teng\u2010Fei","family":"Zhou","sequence":"first","affiliation":[{"name":"Department of Pathogen Biology, Key Laboratory of Tropical Disease Research of Guangdong Province, School of Public Health Southern Medical University  Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ze\u2010Tian","family":"Lai","sequence":"additional","affiliation":[{"name":"Department of Pathogen Biology, Key Laboratory of Tropical Disease Research of Guangdong Province, School of Public Health Southern Medical University  Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuang","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Pathogen Biology, Key Laboratory of Tropical Disease Research of Guangdong Province, School of Public Health Southern Medical University  Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jia\u2010Yong","family":"Zhou","sequence":"additional","affiliation":[{"name":"Department of Pathogen Biology, Key Laboratory of Tropical Disease Research of Guangdong Province, School of Public Health Southern Medical University  Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yang","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Biochemistry &amp; Molecular Biology University of Texas Medical Branch  Galveston Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yang","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Pathogen Biology, Key Laboratory of Tropical Disease Research of Guangdong Province, School of Public Health Southern Medical University  Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ye","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Pathogen Biology, Key Laboratory of Tropical Disease Research of Guangdong Province, School of Public Health Southern Medical University  Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kun","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Pathogen Biology, Key Laboratory of Tropical Disease Research of Guangdong Province, School of Public Health Southern Medical University  Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jin\u2010Bao","family":"Gu","sequence":"additional","affiliation":[{"name":"Department of Pathogen Biology, Key Laboratory of Tropical Disease Research of Guangdong Province, School of Public Health Southern Medical University  Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gong","family":"Cheng","sequence":"additional","affiliation":[{"name":"Tsinghua\u2010Peking Center for Life Sciences, School of Medicine Tsinghua University  Beijing 100084 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7927-691X","authenticated-orcid":false,"given":"Xiao\u2010Guang","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Pathogen Biology, Key Laboratory of Tropical 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