{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,16]],"date-time":"2026-06-16T16:56:39Z","timestamp":1781628999182,"version":"3.54.5"},"reference-count":122,"publisher":"Wiley","license":[{"start":{"date-parts":[[2024,1,21]],"date-time":"2024-01-21T00:00:00Z","timestamp":1705795200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100004901","name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de Minas Gerais","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004901","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003593","name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Insect Science"],"abstract":"<jats:title>Abstract<\/jats:title><jats:p>In arthropods, hematophagy has arisen several times throughout evolution. This specialized feeding behavior offered a highly nutritious diet obtained during blood feeds. On the other hand, blood\u2010sucking arthropods must overcome problems brought on by blood intake and digestion. Host blood complement acts on the bite site and is still active after ingestion, so complement activation is a potential threat to the host's skin feeding environment and to the arthropod gut enterocytes. During evolution, blood\u2010sucking arthropods have selected, either in their saliva or gut, anticomplement molecules that inactivate host blood complement. This review presents an overview of the complement system and discusses the arthropod's salivary and gut anticomplement molecules studied to date, exploring their mechanism of action and other aspects related to the arthropod\u2013host\u2013pathogen interface. The possible therapeutic applications of arthropod's anticomplement molecules are also discussed.<\/jats:p>","DOI":"10.1111\/1744-7917.13317","type":"journal-article","created":{"date-parts":[[2024,1,22]],"date-time":"2024-01-22T03:13:47Z","timestamp":1705893227000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Inhibition of vertebrate complement system by hematophagous arthropods: inhibitory molecules, mechanisms, physiological roles, and applications"],"prefix":"10.1111","author":[{"given":"Mauricio Roberto Vianna","family":"Sant'Anna","sequence":"first","affiliation":[{"name":"Department of Parasitology, Institute of Biological Sciences Universidade Federal de Minas Gerais  Belo Horizonte MG Brazil"},{"name":"Instituto Nacional de Ci\u00eancia e Tecnologia em Entomologia Molecular  Rio de Janeiro RJ Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adalberto Alves","family":"Pereira\u2010Filho","sequence":"additional","affiliation":[{"name":"Department of Parasitology, Institute of Biological Sciences Universidade Federal de Minas Gerais  Belo Horizonte MG Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonio Ferreira","family":"Mendes\u2010Sousa","sequence":"additional","affiliation":[{"name":"Campus Senador Helv\u00eddio Nunes de Barros Universidade Federal do Piau\u00ed  Picos PI Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Naylene Carvalho Sales","family":"Silva","sequence":"additional","affiliation":[{"name":"Department of Parasitology, Institute of Biological Sciences Universidade Federal de Minas Gerais  Belo Horizonte MG Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3357-2497","authenticated-orcid":false,"given":"Nelder Figueiredo","family":"Gontijo","sequence":"additional","affiliation":[{"name":"Department of Parasitology, Institute of Biological Sciences Universidade Federal de Minas Gerais  Belo Horizonte MG Brazil"},{"name":"Instituto Nacional de Ci\u00eancia e Tecnologia em Entomologia Molecular  Rio de Janeiro RJ Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marcos Hor\u00e1cio","family":"Pereira","sequence":"additional","affiliation":[{"name":"Department of Parasitology, Institute of Biological Sciences Universidade Federal de Minas Gerais  Belo Horizonte MG Brazil"},{"name":"Instituto Nacional de Ci\u00eancia e Tecnologia em Entomologia Molecular  Rio de Janeiro RJ Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leonardo Barbosa","family":"Koerich","sequence":"additional","affiliation":[{"name":"Department of Parasitology, Institute of Biological Sciences Universidade Federal de Minas Gerais  Belo Horizonte MG Brazil"},{"name":"Instituto Nacional de Ci\u00eancia e Tecnologia em Entomologia Molecular  Rio de Janeiro RJ 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