{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,30]],"date-time":"2026-06-30T05:50:48Z","timestamp":1782798648503,"version":"3.54.5"},"reference-count":49,"publisher":"Wiley","license":[{"start":{"date-parts":[[2024,2,1]],"date-time":"2024-02-01T00:00:00Z","timestamp":1706745600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Insect Science"],"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Insulin receptors (InR) are an integral component of the insulin\/insulin\u2010like growth factor signaling pathway, which plays a vital role in insect development, lifespan, reproduction, and olfactory sensitivity. However, whether InR participate in the peripheral olfactory system of insects remains unclear. Recently, we found that 2\u2010heptanone (2\u2010HT) affects <jats:italic>AcerInR<\/jats:italic> expression, the gene for an InR protein, in <jats:italic>Apis cerana cerana<\/jats:italic>. We then examined the spatiotemporal expression profile of the gene in <jats:italic>A.\u00a0cerana cerana<\/jats:italic>. The mRNA of <jats:italic>AcerInR<\/jats:italic> was primarily expressed in the antennae, wings, and legs of forager bees, which are probable chemosensory tissues. The results of fluorescence competitive binding assays, combined with site\u2010directed mutagenesis, demonstrated that <jats:italic>AcerOBP6<\/jats:italic> and <jats:italic>AcerOBP14<\/jats:italic> exhibit strong binding affinities to 2\u2010HT. Furthermore, after foragers were fed with double\u2010stranded <jats:italic>AcerInR<\/jats:italic>, the expression levels of <jats:italic>AcerOBP6<\/jats:italic> and <jats:italic>AcerOBP14<\/jats:italic> decreased significantly, as did the electroantennogram responsiveness to 2\u2010HT and some other odorants. In conclusion, our findings provide a foundation for understanding the involvement of AcerInR in the odor perception of <jats:italic>A.\u00a0cerana cerana<\/jats:italic>. Moreover, they offer novel insights into the olfactory recognition mechanism in insects.<\/jats:p>","DOI":"10.1111\/1744-7917.13330","type":"journal-article","created":{"date-parts":[[2024,2,2]],"date-time":"2024-02-02T02:35:15Z","timestamp":1706841315000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Insulin receptor participates in the peripheral olfactory processes of honey bees (<i>Apis cerana cerana<\/i>)"],"prefix":"10.1111","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7227-0374","authenticated-orcid":false,"given":"Huiting","family":"Zhao","sequence":"first","affiliation":[{"name":"College of Life Science Shanxi Agricultural University  Taigu Shanxi China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Longlong","family":"Chen","sequence":"additional","affiliation":[{"name":"College of Life Science Shanxi Agricultural University  Taigu Shanxi 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China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,2]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"crossref","first-page":"1020","DOI":"10.1002\/ps.5612","article-title":"Alteration of insulin signaling to control insect pest by using transformed bacteria expressing dsRNA","volume":"76","author":"Al Baki A.","year":"2020","journal-title":"Pest Management Science"},{"key":"e_1_2_8_3_1","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0204935","article-title":"Application of insulin signaling to predict insect growth rate in Maruca vitrata (Lepidoptera: Crambidae)","volume":"13","author":"Al Baki M.A.","year":"2018","journal-title":"PLoS ONE"},{"key":"e_1_2_8_4_1","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1038\/nature04340","article-title":"Complex social behaviour derived from maternal reproductive traits","volume":"439","author":"Amdam 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