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However, functional analysis of cuticular proteins in the melon aphid has been limited. In this study, we identified an endocuticle structural glycoprotein (ESG) AgSgAbd\u20102\u2010like in the melon aphid\n                    <jats:italic>Aphis gossypii<\/jats:italic>\n                    , which is a member of the RR\u20101 subfamily of the CPR (cuticular protein containing the conserved Rebers\u2013Riddiford motif) chitin\u2010binding proteins. When double\u2010stranded RNA is delivered epidermally,\n                    <jats:italic>AgSgAbd\u20102\u2010like<\/jats:italic>\n                    is knocked down, resulting in molting defects and mortality. The expression of\n                    <jats:italic>AgSgAbd\u20102\u2010like<\/jats:italic>\n                    is comparatively low prior to molting and increases following molting. Ecdysone signaling consistently suppresses\n                    <jats:italic>AgSgAbd\u20102\u2010like<\/jats:italic>\n                    . Histologically, the endocuticle and whole cuticle are thinner in\n                    <jats:italic>AgSgAbd\u20102\u2010like<\/jats:italic>\n                    RNA interference (RNAi) aphids, which is a leading cause of molting defects and mortality. Furthermore, knockdown of any other homolog of ESGs, including AgSgAbd\u20104, AgSgAbd\u20104\u2010like, AgSgAbd\u20108\u2010like, and AgSgAbd\u20109\u2010like, results in molting defects and death, like that by\n                    <jats:italic>AgSgAbd\u20102\u2010like<\/jats:italic>\n                    RNAi. These results indicate that the melon aphid ESGs are conserved in cuticle formation and could be potential targets for RNAi\u2010based pest management.\n                  <\/jats:p>","DOI":"10.1111\/1744-7917.13499","type":"journal-article","created":{"date-parts":[[2025,1,17]],"date-time":"2025-01-17T11:14:37Z","timestamp":1737112477000},"page":"172-182","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["The endocuticle structural glycoprotein AgSgAbd\u20102\u2010like is required for cuticle formation and survival in the melon aphid\n                    <i>Aphis gossypii<\/i>"],"prefix":"10.1111","volume":"33","author":[{"given":"Mingyu","family":"Guo","sequence":"first","affiliation":[{"name":"Department of Plant Biosecurity and MARA Key Laboratory of Surveillance and Management for Plant Quarantine Pests, College of Plant Protection China Agricultural University  Beijing 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