{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T19:14:41Z","timestamp":1791227681077,"version":"4.1.0"},"reference-count":58,"publisher":"Wiley","license":[{"start":{"date-parts":[[2025,9,15]],"date-time":"2025-09-15T00:00:00Z","timestamp":1757894400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Insect Science"],"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Juvenile hormone (JH) and nutrients are both essential for insect ovarian development. However, the molecular mechanisms of synergistic JH\u2010nutrient regulation in ovarian development remain unclear. Here, trehalase 1 (Treh1) was the focus of the crosstalk between JH and nutrients in the ovarian development of <jats:italic>Helicoverpa armigera<\/jats:italic>. The data indicated that a sugar\u2010free diet and a casein\u2010free diet both arrested ovarian development and reduced JH levels in females. The activity of HaTreh1 was up\u2010regulated by sugar starvation or JH treatments, but was down\u2010regulated by casein\u2010free diet treatment. Importantly, knockdown of <jats:italic>HaTreh1<\/jats:italic> severely hindered ovary growth, including decreases in tubal length, egg number, ovary\/total weight ratio, and egg\u2010laying number. Interestingly, the transcription factor Methoprene\u2010tolerant 1 (Met1) directly activated <jats:italic>HaTreh1<\/jats:italic> transcription by binding to the E\u2010box (GTTGAC) in its promoter. Furthermore, HaTreh1 directly bound to the methionine\u2010rich storage protein1 (HaSP1) physically and under JH induction, and knockdown of <jats:italic>HaSP1<\/jats:italic> delayed ovarian growth due to methionine deficiency. Overall, JH orchestrates ovarian development by modulating <jats:italic>HaTreh1<\/jats:italic> transcription and protein activity, which in turn controls trehalose and methionine levels. As a key metabolic executor downstream of JH and nutrient signaling, <jats:italic>HaTreh1<\/jats:italic> integrates sugar and amino acid availability to regulate ovarian development.<\/jats:p>","DOI":"10.1111\/1744-7917.70168","type":"journal-article","created":{"date-parts":[[2025,9,15]],"date-time":"2025-09-15T12:17:59Z","timestamp":1757938679000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Juvenile hormone coordinately regulates trehalose and methionine levels by activating trehalase 1 in insect ovarian development"],"prefix":"10.1111","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8658-817X","authenticated-orcid":false,"given":"Wenli","family":"Zhao","sequence":"first","affiliation":[{"name":"College of Plant Protection Henan Agricultural University  Zhengzhou 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China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1313-2953","authenticated-orcid":false,"given":"Shiheng","family":"An","sequence":"additional","affiliation":[{"name":"College of Plant Protection Henan Agricultural University  Zhengzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,9,15]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1016\/j.ydbio.2018.04.028","article-title":"Insulin signaling acts in adult adipocytes via GSK\u20103\u03b2 and independently of FOXO to control Drosophila female germline stem cell numbers","volume":"440","author":"Armstrong A.R.","year":"2018","journal-title":"Developmental Biology"},{"key":"e_1_2_7_3_1","doi-asserted-by":"crossref","first-page":"477","DOI":"10.1016\/S0022-1910(02)00069-0","article-title":"Effect of age, diet, diapause and juvenile hormone on oogenesis and the amount of 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