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The cytochrome P450 (\n                    <jats:italic>CYP450<\/jats:italic>\n                    ) genes in insects, which are associated with growth, development, and metabolism of both endogenous and exogenous substances, have attracted considerable attention. However, the role of\n                    <jats:italic>CYP450<\/jats:italic>\n                    gene family in\n                    <jats:italic>Ae<\/jats:italic>\n                    .\n                    <jats:italic>albopictus<\/jats:italic>\n                    mosquito development remains largely unexplored. Here, a comprehensive analysis of\n                    <jats:italic>CYP450<\/jats:italic>\n                    genes in mosquitoes, using comparative genomics combined with Illumina short\u2010read and PacBio full\u2010length RNA sequencing, was conducted to characterize\n                    <jats:italic>Ae<\/jats:italic>\n                    .\n                    <jats:italic>albopictus CYP450<\/jats:italic>\n                    genes. As a result, CYPomes of 24 mosquito species were identified, including 174\n                    <jats:italic>CYP450<\/jats:italic>\n                    transcripts in\n                    <jats:italic>Ae<\/jats:italic>\n                    .\n                    <jats:italic>albopictus<\/jats:italic>\n                    genome and 124 isoforms in full length transcriptome, respectively. These\n                    <jats:italic>CYP450<\/jats:italic>\n                    genes were categorized into four\n                    <jats:italic>CYP<\/jats:italic>\n                    clans containing 14 families, exhibiting a power\u2010law distribution pattern. Ecological traits, such as pathogen type and blood source were speculated to be related to\n                    <jats:italic>CYP450<\/jats:italic>\n                    gene family expansion across mosquito species. Gene gains and losses were considered to be the important evolution drivers for shaping the current mosquito\n                    <jats:italic>CYP450<\/jats:italic>\n                    repertoire. Almost all the\n                    <jats:italic>CYP450<\/jats:italic>\n                    genes in\n                    <jats:italic>Ae<\/jats:italic>\n                    .\n                    <jats:italic>albopictus<\/jats:italic>\n                    showed developmental dynamic expression patterns. Additionally, PacBio full\u2010length RNA sequencing revealed the complexity of CYPomes, with alternative splice events, APAs and gene fusion events identified in\n                    <jats:italic>Ae<\/jats:italic>\n                    .\n                    <jats:italic>albopictus CYP450<\/jats:italic>\n                    full length isoforms. Together, this study characterizes the mosquito CYPomes and their evolution history, and reveals the expression dynamics and possible functions of\n                    <jats:italic>CYP450<\/jats:italic>\n                    gene family in the growth, development, and adaptive strategies of\n                    <jats:italic>Ae<\/jats:italic>\n                    .\n                    <jats:italic>albopictus<\/jats:italic>\n                    .\n                  <\/jats:p>","DOI":"10.1111\/1744-7917.70297","type":"journal-article","created":{"date-parts":[[2026,5,12]],"date-time":"2026-05-12T06:41:36Z","timestamp":1778568096000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["The cytochrome P450 gene family of\n                    <i>Aedes albopictus<\/i>\n                    : Insights from comparative genomics and developmental transcriptomics"],"prefix":"10.1111","author":[{"given":"Congshan","family":"Liu","sequence":"first","affiliation":[{"name":"National Institute of Parasitic Diseases, Chinese Center for Disease Control and Prevention (Chinese Center for Tropical Diseases Research); National Key Laboratory of Intelligent Tracking and Forecasting for Infectious Diseases; Key Laboratory of Parasite and Vector Biology, National Health Commission of the People's Republic of China; WHO Collaborating Centre for Tropical Diseases; National Center for International Research on Tropical Diseases Ministry of Science and Technology  Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaokai","family":"Jia","sequence":"additional","affiliation":[{"name":"National Institute of Parasitic Diseases, Chinese Center for Disease Control and Prevention (Chinese Center for Tropical Diseases Research); National Key Laboratory of Intelligent Tracking and Forecasting for Infectious Diseases; Key Laboratory of Parasite and Vector Biology, National Health Commission of the People's Republic of China; WHO Collaborating Centre for Tropical Diseases; National Center for International Research on Tropical Diseases Ministry of Science and Technology  Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhenyu","family":"Yue","sequence":"additional","affiliation":[{"name":"National Institute of Parasitic Diseases, Chinese Center for Disease Control and Prevention (Chinese Center for Tropical Diseases Research); National Key Laboratory of Intelligent Tracking and Forecasting for Infectious Diseases; Key Laboratory of Parasite and Vector Biology, National Health Commission of the People's Republic of China; WHO Collaborating Centre for Tropical Diseases; National Center for International Research on Tropical Diseases Ministry of Science and Technology  Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ying","family":"Wang","sequence":"additional","affiliation":[{"name":"National Institute of Parasitic Diseases, Chinese Center for Disease Control and Prevention (Chinese Center for Tropical Diseases Research); National Key Laboratory of Intelligent Tracking and Forecasting for Infectious Diseases; Key Laboratory of Parasite and Vector Biology, National Health Commission of the People's Republic of China; WHO Collaborating Centre for Tropical Diseases; National Center for International Research on Tropical Diseases Ministry of Science and Technology  Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mei","family":"Zhang","sequence":"additional","affiliation":[{"name":"National Institute of Parasitic Diseases, Chinese Center for Disease Control and Prevention (Chinese Center for Tropical Diseases Research); National Key Laboratory of Intelligent Tracking and Forecasting for Infectious Diseases; Key Laboratory of Parasite and Vector Biology, National Health Commission of the People's Republic of China; WHO Collaborating Centre for Tropical Diseases; National Center for International Research on Tropical Diseases Ministry of Science and Technology  Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hua","family":"Liu","sequence":"additional","affiliation":[{"name":"National Institute of Parasitic Diseases, Chinese Center for Disease Control and Prevention (Chinese Center for Tropical Diseases Research); National Key Laboratory of Intelligent Tracking and Forecasting for Infectious Diseases; Key Laboratory of Parasite and Vector Biology, National Health Commission of the People's Republic of China; WHO Collaborating Centre for Tropical Diseases; National Center for International Research on Tropical Diseases Ministry of Science and Technology  Shanghai 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