{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,29]],"date-time":"2026-07-29T12:05:06Z","timestamp":1785326706044,"version":"3.55.0"},"reference-count":59,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,7,29]],"date-time":"2026-07-29T00:00:00Z","timestamp":1785283200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,7,29]],"date-time":"2026-07-29T00:00:00Z","timestamp":1785283200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Insect Science"],"abstract":"Abstract<\/jats:title>\n \n Spodoptera frugiperda<\/jats:italic>\n (fall armyworm) is a globally distributed and highly destructive migratory pest, while\n Serratia marcescens<\/jats:italic>\n is a widespread entomopathogenic bacterium capable of infecting diverse insects. In this study, oral infection with\n S. marcescens<\/jats:italic>\n strain SM001 exhibited potent virulence, with an LC\n 50<\/jats:sub>\n of 7.40 \u00d7 10\n 6<\/jats:sup>\n CFU\/mL at 168 h post\u2010infection (hpi). Logistic regression modeling demonstrated that the bacterium enters an exponential proliferation phase within the hemolymph approximately 48\u201354 h after infection. Infection significantly upregulated\n Duox<\/jats:italic>\n and\n Nos<\/jats:italic>\n , induced severe oxidative stress, and activated an apoptotic cascade involving\n Cyt c<\/jats:italic>\n ,\n p53<\/jats:italic>\n , and\n caspase<\/jats:italic>\n , culminating in extensive midgut epithelial cell apoptosis. Mitigating oxidative stress via targeted Vitamin C supplementation or\n Duox<\/jats:italic>\n knockdown alleviated midgut tissue damage and delayed bacterial dissemination. However, exogenous Vitamin C treatment decreased larval mortality, whereas\n Duox<\/jats:italic>\n knockdown failed to improve overall survival, revealing a critical physiological trade\u2010off between ROS\u2010mediated pathogen clearance and host immunopathology. Overall, SM001 disrupts midgut redox homeostasis, drives excessive H\n 2<\/jats:sub>\n O\n 2<\/jats:sub>\n accumulation, and breaches the intestinal barrier to facilitate hemocoel translocation, ultimately leading to lethal systemic septicemia. These findings highlight the pivotal role of host\u2010mediated immunopathology in bacterial pathogenesis and provide a robust theoretical foundation for developing advanced microbial control strategies against\n S. frugiperda<\/jats:italic>\n .\n <\/jats:p>","DOI":"10.1111\/1744-7917.70334","type":"journal-article","created":{"date-parts":[[2026,7,29]],"date-time":"2026-07-29T11:19:55Z","timestamp":1785323995000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Serratia marcescens<\/i>\n SM001\u2010induced oxidative stress accelerates\n Spodoptera frugiperda<\/i>\n mortality by promoting midgut apoptosis"],"prefix":"10.1111","author":[{"given":"Wei","family":"Lin","sequence":"first","affiliation":[{"name":"Yuelushan Laboratory Hunan Agricultural University Changsha China"},{"name":"Hunan Provincial Key Laboratory for Biology and Control of Plant Diseases and Insect Pests College of Plant Protection Hunan Agricultural University Changsha China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhengkun","family":"Xiao","sequence":"additional","affiliation":[{"name":"Yuelushan Laboratory Hunan Agricultural University Changsha China"},{"name":"Hunan Provincial Key Laboratory for Biology and Control of Plant Diseases and Insect Pests College of Plant Protection Hunan Agricultural University Changsha China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiajun","family":"Gao","sequence":"additional","affiliation":[{"name":"Yuelushan Laboratory Hunan Agricultural University Changsha China"},{"name":"Hunan Provincial Key Laboratory for Biology and Control of Plant Diseases and Insect Pests College of Plant Protection Hunan Agricultural University Changsha China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaodie","family":"Zhang","sequence":"additional","affiliation":[{"name":"Yuelushan Laboratory Hunan Agricultural University Changsha China"},{"name":"Hunan Provincial Key Laboratory for Biology and Control of Plant Diseases and Insect Pests College of Plant Protection Hunan Agricultural University Changsha China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiaodi","family":"Wang","sequence":"additional","affiliation":[{"name":"Yuelushan Laboratory Hunan Agricultural University Changsha China"},{"name":"Hunan Provincial Key Laboratory for Biology and Control of Plant Diseases and Insect Pests College of Plant Protection Hunan Agricultural University Changsha China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jinping","family":"Liu","sequence":"additional","affiliation":[{"name":"Yuelushan Laboratory Hunan Agricultural University Changsha China"},{"name":"Hunan Provincial Key Laboratory for Biology and Control of Plant Diseases and Insect Pests College of Plant Protection Hunan Agricultural University Changsha China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6841-0095","authenticated-orcid":false,"given":"Guo\u2010Hua","family":"Huang","sequence":"additional","affiliation":[{"name":"Yuelushan Laboratory Hunan Agricultural University Changsha China"},{"name":"Hunan Provincial Key Laboratory for Biology and Control of Plant Diseases and Insect Pests College of Plant Protection Hunan Agricultural University Changsha China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,7,29]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"crossref","DOI":"10.1016\/j.jip.2021.107562","article-title":"Comparative response of Spodoptera litura challenged per os with Serratia marcescens strains differing in virulence","volume":"183","author":"Aggarwal C.","year":"2021","journal-title":"Journal of Invertebrate Pathology"},{"key":"e_1_2_8_3_1","doi-asserted-by":"crossref","first-page":"631","DOI":"10.1007\/s10526-015-9674-3","article-title":"Chitinolytic activity in Serratia marcescens (strain SEN) and potency against different larval instars of Spodoptera litura with effect of sublethal doses on insect development","volume":"60","author":"Aggarwal C.","year":"2015","journal-title":"Biocontrol"},{"key":"e_1_2_8_4_1","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1016\/j.jip.2016.12.004","article-title":"Characterization of putative virulence factors of Serratia marcescens strain SEN for pathogenesis in Spodoptera litura","volume":"143","author":"Aggarwal C.","year":"2017","journal-title":"Journal of Invertebrate Pathology"},{"key":"e_1_2_8_5_1","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1111\/1744-7917.13489","article-title":"Pathogenicity of Serratia marcescens strains as biological control agent: implications for sustainable pest management","volume":"33","author":"Akhtar M.R.","year":"2026","journal-title":"Insect Science"},{"key":"e_1_2_8_6_1","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1093\/gerona\/63.1.35","article-title":"The effects of vitamin supplementation on Drosophila life span under normoxia and under oxidative stress","volume":"63","author":"Bahadorani S.","year":"2008","journal-title":"Journals of Gerontology Series A: Biological Sciences and Medical Sciences"},{"key":"e_1_2_8_7_1","doi-asserted-by":"crossref","DOI":"10.1016\/j.celrep.2025.115404","article-title":"Bacterial\u2010induced DUOX\u2010ROS regulates the IMD immune pathway in the gut by modulating the peritrophic matrix","volume":"44","author":"Bai S.","year":"2025","journal-title":"Cell Reports"},{"key":"e_1_2_8_8_1","doi-asserted-by":"crossref","first-page":"1551","DOI":"10.1016\/j.phytochem.2011.01.040","article-title":"Tannins in plant\u2010herbivore interactions","volume":"72","author":"Barbehenn R.V.","year":"2011","journal-title":"Phytochemistry"},{"key":"e_1_2_8_9_1","doi-asserted-by":"crossref","first-page":"781","DOI":"10.1603\/EC13374","article-title":"Baseline susceptibility and monitoring of Brazilian populations of Spodoptera frugiperda (Lepidoptera: Noctuidae) and Diatraea saccharalis (Lepidoptera: Crambidae) to Vip3Aa20 insecticidal protein","volume":"107","author":"Bernardi O.","year":"2014","journal-title":"Journal of Economic Entomology"},{"key":"e_1_2_8_10_1","doi-asserted-by":"crossref","DOI":"10.3389\/fcimb.2024.1323157","article-title":"Vairimorpha (Nosema) ceranaecan promote Serratia development in honeybee gut: an underrated threat for bees?","volume":"14","author":"Braglia C.","year":"2024","journal-title":"Frontiers in Cellular and Infection Microbiology"},{"key":"e_1_2_8_11_1","doi-asserted-by":"crossref","first-page":"15196","DOI":"10.1073\/pnas.0604865103","article-title":"Midgut bacteria required for Bacillus thuringiensis insecticidal activity","volume":"103","author":"Broderick N.A.","year":"2006","journal-title":"Proceedings of the National Academy of Sciences USA"},{"key":"e_1_2_8_12_1","doi-asserted-by":"crossref","first-page":"615","DOI":"10.1038\/nrmicro3074","article-title":"Gut homeostasis in a microbial world: insights from Drosophila melanogaster","volume":"11","author":"Buchon N.","year":"2013","journal-title":"Nature Reviews Microbiology"},{"key":"e_1_2_8_13_1","doi-asserted-by":"crossref","first-page":"200","DOI":"10.1016\/j.chom.2009.01.003","article-title":"Drosophila intestinal response to bacterial infection: activation of host defense and stem cell proliferation","volume":"5","author":"Buchon N.","year":"2009","journal-title":"Cell Host & Microbe"},{"key":"e_1_2_8_14_1","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1007\/s10565-013-9240-7","article-title":"Effect of boric acid on antioxidant enzyme activity, lipid peroxidation, and ultrastructure of midgut and fat body of Galleria mellonella","volume":"29","author":"B\u00fcy\u00fckg\u00fczel E.","year":"2013","journal-title":"Cell Biology and Toxicology"},{"key":"e_1_2_8_15_1","doi-asserted-by":"crossref","DOI":"10.1016\/j.pestbp.2025.106642","article-title":"Synergistic enhancement of emamectin benzoate and Metarhizium anisopliae against late\u2010instar Spodoptera frugiperda by promoting fungal pathogenicity","volume":"215","author":"Cao T.","year":"2025","journal-title":"Pesticide Biochemistry and Physiology"},{"key":"e_1_2_8_16_1","doi-asserted-by":"crossref","first-page":"4465","DOI":"10.1038\/emboj.2011.318","article-title":"BAX inhibitor\u20101 regulates autophagy by controlling the IRE1\u03b1 branch of the unfolded protein response","volume":"30","author":"Castillo K.","year":"2011","journal-title":"The EMBO Journal"},{"key":"e_1_2_8_17_1","doi-asserted-by":"crossref","first-page":"6667","DOI":"10.1038\/s41598-019-43074-0","article-title":"Toxicity and cytopathology mediated by Bacillus thuringiensis in the midgut of Anticarsia gemmatalis (Lepidoptera: Noctuidae)","volume":"9","author":"Castro B.M.D.C.E.","year":"2019","journal-title":"Scientific Reports"},{"key":"e_1_2_8_18_1","doi-asserted-by":"crossref","first-page":"23995","DOI":"10.1074\/jbc.M112.376095","article-title":"Reactive oxygen species\u2010mediated immunity against Leishmania mexicana and Serratia marcescens in the phlebotomine sand fly Lutzomyia longipalpis","volume":"287","author":"Diaz\u2010Albiter H.","year":"2012","journal-title":"Journal of Biological Chemistry"},{"key":"e_1_2_8_19_1","doi-asserted-by":"crossref","DOI":"10.1016\/j.pestbp.2026.106970","article-title":"Engineering Bacillus thuringiensis Cyt1Aa to function as a surrogate receptor of Cry1A lepidopteran insecticidal proteins","volume":"219","author":"do Nascimento N.A.","year":"2026","journal-title":"Pesticide Biochemistry and Physiology"},{"key":"e_1_2_8_20_1","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1016\/j.ibmb.2019.04.005","article-title":"Molecular regulations of metabolism during immune response in insects","volume":"109","author":"Dolezal T.","year":"2019","journal-title":"Insect Biochemistry and Molecular Biology"},{"key":"e_1_2_8_21_1","doi-asserted-by":"crossref","first-page":"1466","DOI":"10.3390\/molecules29071466","article-title":"Gene cloning, heterologous expression, and in silico analysis of chitinase B from Serratia marcescens for biocontrol of Spodoptera frugiperda larvae infesting maize crops","volume":"29","author":"El\u2010Sayed G.M.","year":"2024","journal-title":"Molecules"},{"key":"e_1_2_8_22_1","doi-asserted-by":"crossref","first-page":"527","DOI":"10.1146\/annurev-arplant-050718-095910","article-title":"Molecular interactions between plants and insect herbivores","volume":"70","author":"Erb M.","year":"2019","journal-title":"Annual Review of Plant Biology"},{"key":"e_1_2_8_23_1","doi-asserted-by":"crossref","first-page":"689","DOI":"10.1038\/s41573-021-00233-1","article-title":"Targeting oxidative stress in disease: promise and limitations of antioxidant therapy","volume":"20","author":"Forman H.J.","year":"2021","journal-title":"Nature Reviews Drug Discovery"},{"key":"e_1_2_8_24_1","doi-asserted-by":"crossref","first-page":"589","DOI":"10.1093\/emboj\/19.4.589","article-title":"Induction of apoptosis by Drosophila reaper, hid and grim through inhibition of IAP function","volume":"19","author":"Goyal L.","year":"2000","journal-title":"The EMBO Journal"},{"key":"e_1_2_8_25_1","doi-asserted-by":"crossref","first-page":"933","DOI":"10.3390\/insects16090933","article-title":"Changes in gut microbiota, midgut structure, and gene expression of Spodoptera frugiperda infected by Serratia marcescens","volume":"16","author":"Guo Y.","year":"2025","journal-title":"Insects"},{"key":"e_1_2_8_26_1","doi-asserted-by":"crossref","first-page":"847","DOI":"10.1126\/science.1117311","article-title":"A direct role for dual oxidase in Drosophila gut immunity","volume":"310","author":"Ha E.M.","year":"2005","journal-title":"Science"},{"key":"e_1_2_8_27_1","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1016\/j.devcel.2004.11.007","article-title":"An antioxidant system required for host protection against gut infection in Drosophila","volume":"8","author":"Ha E.M.","year":"2005","journal-title":"Developmental Cell"},{"key":"e_1_2_8_28_1","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1146\/annurev.ento.54.110807.090559","article-title":"New insights into peritrophic matrix synthesis, architecture, and function","volume":"54","author":"Hegedus D.","year":"2009","journal-title":"Annual Review of Entomology"},{"key":"e_1_2_8_29_1","doi-asserted-by":"crossref","first-page":"602","DOI":"10.1002\/ps.7787","article-title":"Serratia marcescens induces apoptosis in Diaphorina citri gut cells via reactive oxygen species\u2010mediated oxidative stress","volume":"80","author":"Hu W.","year":"2024","journal-title":"Pest Management Science"},{"key":"e_1_2_8_30_1","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0225873","article-title":"Dual oxidase DUOX and toll\u2010like receptor 3 TLR3 in the Toll pathway suppress zoonotic pathogens through regulating the intestinal bacterial community homeostasis in Hermetia illucens L","volume":"15","author":"Huang Y.","year":"2020","journal-title":"PLoS ONE"},{"key":"e_1_2_8_31_1","doi-asserted-by":"crossref","first-page":"5876","DOI":"10.1074\/jbc.M113.544536","article-title":"Serratia marcescens suppresses host cellular immunity via the production of an adhesion\u2010inhibitory factor against immunosurveillance cells","volume":"289","author":"Ishii K.","year":"2014","journal-title":"Journal of Biological Chemistry"},{"key":"e_1_2_8_32_1","doi-asserted-by":"crossref","DOI":"10.1016\/j.pestbp.2025.106477","article-title":"Midgut microorganisms transformed into hemolymph pathogens: mediating DUOX\u2010ROS immune response to regulate the insecticidal activity of Bacillus thuringiensis against Spodoptera exigua","volume":"213","author":"Ji Y.","year":"2025","journal-title":"Pesticide Biochemistry and Physiology"},{"key":"e_1_2_8_33_1","doi-asserted-by":"crossref","first-page":"1343","DOI":"10.1016\/j.cell.2009.05.014","article-title":"Cytokine\/JAK\/STAT signaling mediates regeneration and homeostasis in the Drosophila midgut","volume":"137","author":"Jiang H.","year":"2009","journal-title":"Cell"},{"key":"e_1_2_8_34_1","doi-asserted-by":"crossref","first-page":"1123","DOI":"10.1002\/ps.7284","article-title":"Insight into the regulation of the Nrf2 pathway in response to ascovirus infection in Spodoptera exigua","volume":"79","author":"Jin R.","year":"2023","journal-title":"Pest Management Science"},{"key":"e_1_2_8_35_1","first-page":"116","article-title":"Role of DUOX in gut inflammation: lessons from Drosophila model of gut\u2010microbiota interactions","volume":"3","author":"Kim S.H.","year":"2014","journal-title":"Frontiers in Cellular and Infection Microbiology"},{"key":"e_1_2_8_36_1","doi-asserted-by":"crossref","first-page":"1451","DOI":"10.1093\/emboj\/cdg159","article-title":"Virulence factors of the human opportunistic pathogen Serratia marcescens identified by in vivo screening","volume":"22","author":"Kurz C.L.","year":"2003","journal-title":"The EMBO Journal"},{"key":"e_1_2_8_37_1","doi-asserted-by":"crossref","first-page":"716","DOI":"10.1016\/j.chom.2016.10.010","article-title":"Enterocyte purge and rapid recovery is a resilience reaction of the gut epithelium to pore\u2010forming toxin attack","volume":"20","author":"Lee K.\u2010Z.","year":"2016","journal-title":"Cell Host & Microbe"},{"key":"e_1_2_8_38_1","doi-asserted-by":"crossref","first-page":"697","DOI":"10.1146\/annurev.immunol.25.022106.141615","article-title":"The host defense of Drosophila melanogaster","volume":"25","author":"Lemaitre B.","year":"2007","journal-title":"Annual Review of Immunology"},{"key":"e_1_2_8_39_1","doi-asserted-by":"crossref","first-page":"1413","DOI":"10.1007\/s10340-025-01908-z","article-title":"Gut bacteria of the fall armyworm, Spodoptera frugiperda, promote host resistance against the toxic effects of lufenuron","volume":"98","author":"Li Q.","year":"2025","journal-title":"Journal of Pest Science"},{"key":"e_1_2_8_40_1","doi-asserted-by":"crossref","first-page":"487","DOI":"10.1007\/s10495-006-5059-5","article-title":"Activation pathways and signal\u2010mediated upregulation of the insect Spodoptera frugiperda caspase\u20101","volume":"11","author":"Liu Q.","year":"2006","journal-title":"Apoptosis"},{"key":"e_1_2_8_41_1","doi-asserted-by":"crossref","first-page":"3491","DOI":"10.1002\/ps.8054","article-title":"Screening and functional validation of the core detoxification genes conferring broad\u2010spectrum response to insecticides in Spodoptera frugiperda","volume":"80","author":"Lu Z.","year":"2024","journal-title":"Pest Management Science"},{"key":"e_1_2_8_42_1","doi-asserted-by":"crossref","first-page":"328","DOI":"10.1002\/ps.70195","article-title":"Insights into the toxicity effects of indoxacarb against Spodoptera frugiperda using metabolomics combined with mass spectrometry imaging","volume":"82","author":"Ma L.","year":"2026","journal-title":"Pest Management Science"},{"key":"e_1_2_8_43_1","doi-asserted-by":"crossref","DOI":"10.1016\/j.jip.2025.108327","article-title":"Fungal\u2010bacterial interactions leading to increased insect mortality: Trichoderma xixiacum enhances the pathogenicity of Serratia marcescens in Protaetia brevitarsis larvae","volume":"211","author":"Mansour A.","year":"2025","journal-title":"Journal of Invertebrate Pathology"},{"key":"e_1_2_8_44_1","doi-asserted-by":"crossref","DOI":"10.1371\/journal.ppat.0030173","article-title":"A model of bacterial intestinal infections in Drosophila melanogaster","volume":"3","author":"Nehme N.T.","year":"2007","journal-title":"PLoS Pathogens"},{"key":"e_1_2_8_45_1","doi-asserted-by":"crossref","DOI":"10.1016\/j.pestbp.2024.106255","article-title":"Rapid adaptation of Bacillus thuringiensis to alkaline environments via the L\u2010lactate metabolism pathway regulated by the CRP\/FNR family regulator LtmR","volume":"208","author":"Peng Q.","year":"2025","journal-title":"Pesticide Biochemistry and Physiology"},{"key":"e_1_2_8_46_1","doi-asserted-by":"crossref","DOI":"10.1371\/journal.ppat.1002223","article-title":"Nutritional immunology: a multi\u2010dimensional approach","volume":"7","author":"Ponton F.","year":"2011","journal-title":"PLoS Pathogens"},{"key":"e_1_2_8_47_1","first-page":"6780","article-title":"The fliR gene contributes to the virulence of S. marcescens in a Drosophila intestinal infection model","volume":"12","author":"Rahme B.S.","year":"2022","journal-title":"Scientific Reports"},{"key":"e_1_2_8_48_1","doi-asserted-by":"crossref","DOI":"10.1016\/j.pestbp.2025.106658","article-title":"Impact of high substrate concentrations and different culture systems on the quality and virulence of Bacillus thuringiensis against Spodoptera frugiperda","volume":"215","author":"Robles\u2010Ibarra M.","year":"2025","journal-title":"Pesticide Biochemistry and Physiology"},{"key":"e_1_2_8_49_1","doi-asserted-by":"crossref","first-page":"889","DOI":"10.1038\/nri2432","article-title":"Two ways to survive infection: what resistance and tolerance can teach us about treating infectious diseases","volume":"8","author":"Schneider D.S.","year":"2008","journal-title":"Nature Reviews Immunology"},{"key":"e_1_2_8_50_1","doi-asserted-by":"crossref","first-page":"4147","DOI":"10.1242\/dev.052506","article-title":"The Hippo pathway regulates intestinal stem cell proliferation during Drosophila adult midgut regeneration","volume":"137","author":"Shaw R.L.","year":"2010","journal-title":"Development"},{"key":"e_1_2_8_51_1","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1038\/s41580-020-0230-3","article-title":"Reactive oxygen species (ROS) as pleiotropic physiological signalling agents","volume":"21","author":"Sies H.","year":"2020","journal-title":"Nature Reviews Molecular Cell Biology"},{"key":"e_1_2_8_52_1","doi-asserted-by":"crossref","DOI":"10.1016\/j.pestbp.2025.106293","article-title":"Insecticidal activities of essential oil from Hedychium coronarium rhizome and its mixture of compounds against the fall armyworm Spodoptera frugiperda (Lepidoptera: Noctuidae)","volume":"208","author":"Vijitkul P.","year":"2025","journal-title":"Pesticide Biochemistry and Physiology"},{"key":"e_1_2_8_53_1","doi-asserted-by":"crossref","first-page":"1241","DOI":"10.1016\/j.ibmb.2007.07.013","article-title":"Molecular characterization of an inhibitor of apoptosis in the Egyptian armyworm, Spodoptera littoralis, and midgut cell death during metamorphosis","volume":"37","author":"Vilaplana L.","year":"2007","journal-title":"Insect Biochemistry and Molecular Biology"},{"key":"e_1_2_8_54_1","doi-asserted-by":"crossref","first-page":"11414","DOI":"10.1073\/pnas.0502240102","article-title":"Drosophila host defense after oral infection by an entomopathogenic Pseudomonas species","volume":"102","author":"Vodovar N.","year":"2005","journal-title":"Proceedings of the National Academy of Sciences USA"},{"key":"e_1_2_8_55_1","doi-asserted-by":"crossref","DOI":"10.1016\/j.cropro.2025.107446","article-title":"Laboratory evaluation of the entomopathogenic fungus Beauveria bassiana, bacterium Bacillus thuringiensis, and insecticide emamectin benzoate treatments, alone and in dual combinations against Spodoptera frugiperda","volume":"200","author":"Wakil W.","year":"2026","journal-title":"Crop Protection"},{"key":"e_1_2_8_56_1","doi-asserted-by":"crossref","first-page":"5994","DOI":"10.1073\/pnas.1703546114","article-title":"Insect pathogenic fungus interacts with the gut microbiota to accelerate mosquito mortality","volume":"114","author":"Wei G.","year":"2017","journal-title":"Proceedings of the National Academy of Sciences USA"},{"key":"e_1_2_8_57_1","doi-asserted-by":"crossref","DOI":"10.1016\/j.pestbp.2025.106303","article-title":"Suppression of adipokinetic hormones enhances ascovirus HvAV\u20103h killing speed in Helicoverpa armigera","volume":"208","author":"Xiao Z.","year":"2025","journal-title":"Pesticide Biochemistry and Physiology"},{"key":"e_1_2_8_58_1","doi-asserted-by":"crossref","first-page":"1037","DOI":"10.1038\/ismej.2015.202","article-title":"The dual oxidase gene BdDuox regulates the intestinal bacterial community homeostasis of Bactrocera dorsalis","volume":"10","author":"Yao Z.","year":"2016","journal-title":"The ISME Journal"},{"key":"e_1_2_8_59_1","doi-asserted-by":"crossref","first-page":"897","DOI":"10.1016\/j.immuni.2018.04.010","article-title":"Cell\u2010specific IMD\u2010NF\u2010\u03baB responses enable simultaneous antibacterial immunity and intestinal epithelial cell shedding upon bacterial infection","volume":"48","author":"Zhai Z.","year":"2018","journal-title":"Immunity"},{"key":"e_1_2_8_60_1","doi-asserted-by":"crossref","DOI":"10.1016\/j.pestbp.2025.106908","article-title":"Hyperlipidemia of Spodoptera exigua larvae caused by the infection of Heliothis virescens ascovirus 3h contributes to the viral DNA replication and virions\u2019 storage","volume":"218","author":"Zhai Z.","year":"2026","journal-title":"Pesticide Biochemistry and Physiology"}],"container-title":["Insect Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/1744-7917.70334","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/1744-7917.70334","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/1744-7917.70334","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,29]],"date-time":"2026-07-29T11:20:04Z","timestamp":1785324004000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/1744-7917.70334"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,7,29]]},"references-count":59,"alternative-id":["10.1111\/1744-7917.70334"],"URL":"https:\/\/doi.org\/10.1111\/1744-7917.70334","archive":["Portico"],"relation":{},"ISSN":["1672-9609","1744-7917"],"issn-type":[{"value":"1672-9609","type":"print"},{"value":"1744-7917","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,7,29]]},"assertion":[{"value":"2026-04-01","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-06-29","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-07-29","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"1744-7917.70334"}}