{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,20]],"date-time":"2026-08-20T06:25:17Z","timestamp":1787207117393,"version":"build-2736575974"},"reference-count":66,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,8,19]],"date-time":"2026-08-19T00:00:00Z","timestamp":1787097600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,8,19]],"date-time":"2026-08-19T00:00:00Z","timestamp":1787097600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2024YFD2300800"],"award-info":[{"award-number":["2024YFD2300800"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["32572820"],"award-info":[{"award-number":["32572820"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Insect Science"],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Heat stress threatens insect survival by disrupting tissue homeostasis and physiological performance, yet how insects preserve tissue function under high temperature remains poorly understood. Members of the major allergen gene family are widely distributed in insects, but whether and how they contribute to heat stress adaptation remains unclear. Here, using the tropical and subtropical horticultural pest\n                    <jats:italic>Bactrocera dorsalis<\/jats:italic>\n                    , a species capable of surviving temperatures above 40 \u00b0C, as a model, we identified a previously uncharacterized heat\u2010responsive gene,\n                    <jats:italic>matl2<\/jats:italic>\n                    , which encodes a secreted lipid\u2010binding protein and serves as a key regulator of muscle function during heat stress. Matl2 protein is secreted and targets the thoracic muscles. Under heat stress, the downregulation of\n                    <jats:italic>matl2<\/jats:italic>\n                    maintains muscle protein homeostasis, potentially through autophagy and lysosome system, which might involve modulation of the PIP\n                    <jats:sub>3<\/jats:sub>\n                    \u2013Akt signaling pathway. Moreover, Matl2 preserves locomotor performance under heat stress. Together, these findings uncover a lipid\u2010mediated signaling axis that safeguards muscle proteostasis, providing insight into a strategy insects employ to cope with heat stress.\n                  <\/jats:p>","DOI":"10.1111\/1744-7917.70342","type":"journal-article","created":{"date-parts":[[2026,8,20]],"date-time":"2026-08-20T06:00:04Z","timestamp":1787205604000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["A ventral nerve cord enriched major allergen family gene maintains muscle function under heat stress in\n                    <i>Bactrocera dorsalis<\/i>"],"prefix":"10.1111","author":[{"ORCID":"https:\/\/orcid.org\/0009-0000-8514-350X","authenticated-orcid":false,"given":"Jiashuo","family":"Li","sequence":"first","affiliation":[{"name":"National Key Laboratory for Germplasm Innovation and Utilization for Fruit and Vegetable Horticultural Crops Hubei Hongshan Laboratory Hubei Key Laboratory of Insect Resource Application and Sustainable Pest Control China\u2013Australia Joint Research Centre for Horticultural and Urban Pests Institute of Urban and Horticultural Entomology College of Plant Science and Technology Huazhong Agricultural University  Wuhan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ban","family":"Chen","sequence":"additional","affiliation":[{"name":"School of Life and Health Sciences Hubei University of Technology  Wuhan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yong","family":"Zhang","sequence":"additional","affiliation":[{"name":"National Key Laboratory for Germplasm Innovation and Utilization for Fruit and Vegetable Horticultural Crops Hubei Hongshan Laboratory Hubei Key Laboratory of Insect Resource Application and Sustainable Pest Control China\u2013Australia Joint Research Centre for Horticultural and Urban Pests Institute of Urban and Horticultural Entomology College of Plant Science and Technology Huazhong Agricultural University  Wuhan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luyang","family":"Li","sequence":"additional","affiliation":[{"name":"National Key Laboratory for Germplasm Innovation and Utilization for Fruit and Vegetable Horticultural Crops Hubei Hongshan Laboratory Hubei Key Laboratory of Insect Resource Application and Sustainable Pest Control China\u2013Australia Joint Research Centre for Horticultural and Urban Pests Institute of Urban and Horticultural Entomology College of Plant Science and Technology Huazhong Agricultural University  Wuhan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chenfan","family":"Duan","sequence":"additional","affiliation":[{"name":"School of Life and Health Sciences Hubei University of Technology  Wuhan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaocong","family":"Wang","sequence":"additional","affiliation":[{"name":"Hubei Key Laboratory of Agricultural Bioinformatics College of Informatics Huazhong Agricultural University  Wuhan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weiwei","family":"Zheng","sequence":"additional","affiliation":[{"name":"National Key Laboratory for Germplasm Innovation and Utilization for Fruit and Vegetable Horticultural Crops Hubei Hongshan Laboratory Hubei Key Laboratory of Insect Resource Application and Sustainable Pest Control China\u2013Australia Joint Research Centre for Horticultural and Urban Pests Institute of Urban and Horticultural Entomology College of Plant Science and Technology Huazhong Agricultural University  Wuhan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6368-5903","authenticated-orcid":false,"given":"Hongyu","family":"Zhang","sequence":"additional","affiliation":[{"name":"National Key Laboratory for Germplasm Innovation and Utilization for Fruit and Vegetable Horticultural Crops Hubei Hongshan Laboratory Hubei Key Laboratory of Insect Resource Application and Sustainable Pest Control China\u2013Australia Joint Research Centre for Horticultural and Urban Pests Institute of Urban and Horticultural Entomology College of Plant Science and Technology Huazhong Agricultural University  Wuhan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9484-3409","authenticated-orcid":false,"given":"Xiaoxue","family":"Li","sequence":"additional","affiliation":[{"name":"National Key Laboratory for Germplasm Innovation and Utilization for Fruit and Vegetable Horticultural Crops Hubei Hongshan Laboratory Hubei Key Laboratory of Insect Resource Application and Sustainable Pest Control China\u2013Australia Joint Research Centre for Horticultural and Urban Pests Institute of Urban and Horticultural Entomology College of Plant Science and Technology Huazhong Agricultural University  Wuhan China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,8,19]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1016\/j.softx.2015.06.001","article-title":"GROMACS: high performance molecular simulations through multi\u2010level parallelism from laptops to supercomputers","volume":"1","author":"Abraham M.J.","year":"2015","journal-title":"SoftwareX"},{"key":"e_1_2_7_3_1","doi-asserted-by":"crossref","first-page":"493","DOI":"10.1038\/s41586-024-07487-w","article-title":"Accurate structure prediction of biomolecular interactions with AlphaFold 3","volume":"630","author":"Abramson J.","year":"2024","journal-title":"Nature"},{"key":"e_1_2_7_4_1","doi-asserted-by":"crossref","first-page":"W530","DOI":"10.1093\/nar\/gkab294","article-title":"PLIP 2021: expanding the scope of the protein\u2010ligand interaction profiler to DNA and RNA","volume":"49","author":"Adasme 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