{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,21]],"date-time":"2026-08-21T06:24:05Z","timestamp":1787293445613,"version":"build-2736575974"},"reference-count":49,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,8,20]],"date-time":"2026-08-20T00:00:00Z","timestamp":1787184000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,8,20]],"date-time":"2026-08-20T00:00:00Z","timestamp":1787184000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["32372951"],"award-info":[{"award-number":["32372951"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100021171","name":"Basic and Applied Basic Research Foundation of Guangdong Province","doi-asserted-by":"publisher","award":["2024A1515011575"],"award-info":[{"award-number":["2024A1515011575"]}],"id":[{"id":"10.13039\/501100021171","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Insect Science"],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Bombyx mori cytoplasmic polyhedrosis virus (BmCPV), a double\u2010stranded RNA reovirus, causes significant losses in sericulture; however, the host factors that support its replication remain poorly understood. Here, we identify\n                    <jats:italic>Tudor staphylococcal nuclease<\/jats:italic>\n                    (\n                    <jats:italic>TSN<\/jats:italic>\n                    ) as a critical pro\u2010viral host factor in silkworms. TSN is a multifunctional, evolutionarily conserved protein involved in transcription and RNA processing.\n                    <jats:italic>BmTSN<\/jats:italic>\n                    expression was increased markedly in BmCPV\u2010infected midgut tissues. RNAi\u2010mediated knockdown in BmN cells suppresses viral replication, whereas overexpression enhances it. Mechanistically,\n                    <jats:italic>BmTSN<\/jats:italic>\n                    drives a metabolic shift by enhancing lipid accumulation; knockdown of\n                    <jats:italic>BmTSN<\/jats:italic>\n                    reduces the expression of\n                    <jats:italic>BmSREBP1<\/jats:italic>\n                    and other lipid\u2010regulatory genes. Disruption of either\n                    <jats:italic>BmTSN<\/jats:italic>\n                    or\n                    <jats:italic>BmSREBP1<\/jats:italic>\n                    reduces BmCPV replication. In a reciprocal effect, RNAi\u2010mediated knockdown of\n                    <jats:italic>BmSREBP1<\/jats:italic>\n                    also reduces\n                    <jats:italic>BmTSN<\/jats:italic>\n                    expression. Furthermore,\n                    <jats:italic>BmSREBP1<\/jats:italic>\n                    transcriptionally activates\n                    <jats:italic>BmTSN<\/jats:italic>\n                    expression by binding to the\n                    <jats:italic>BmTSN<\/jats:italic>\n                    promoter, suggesting a regulatory loop between these factors. Together, these findings reveal a virus\u2010induced\n                    <jats:italic>BmTSN\u2010BmSREBP1<\/jats:italic>\n                    axis that links host lipid metabolism to BmCPV replication. This work identifies\n                    <jats:italic>BmTSN<\/jats:italic>\n                    as a key host\u2010dependency factor and provides new insights into virus\u2013host interactions in insects.\n                  <\/jats:p>","DOI":"10.1111\/1744-7917.70344","type":"journal-article","created":{"date-parts":[[2026,8,21]],"date-time":"2026-08-21T05:34:26Z","timestamp":1787290466000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Tudor staphylococcal nuclease promotes Bombyx mori cytoplasmic polyhedrosis virus replication through lipid metabolic reprogramming in silkworms"],"prefix":"10.1111","author":[{"ORCID":"https:\/\/orcid.org\/0009-0009-7957-5547","authenticated-orcid":false,"given":"Mian Muhammad","family":"Awais","sequence":"first","affiliation":[{"name":"Guangdong Provincial Key Laboratory of Agro\u2010Animal Genomics and Molecular Breeding, College of Animal Science South China Agricultural University  Guangzhou China"},{"name":"State Key Laboratory of Swine and Poultry Breeding Industry College of Animal Science National Engineering Research Center for Breeding Swine Industry\/Guangdong Laboratory for Lingnan Modern Agriculture\/Guangdong Provincial Key Laboratory of Animal Nutrition Control South China Agricultural University  Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nasir","family":"Mehmood","sequence":"additional","affiliation":[{"name":"Guangdong Provincial Key Laboratory of Agro\u2010Animal Genomics and Molecular Breeding, College of Animal Science South China Agricultural University  Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wensheng","family":"Yu","sequence":"additional","affiliation":[{"name":"Guangdong Provincial Key Laboratory of Agro\u2010Animal Genomics and Molecular Breeding, College of Animal Science South China Agricultural University  Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ayman","family":"Asif","sequence":"additional","affiliation":[{"name":"Department of Entomology University of Agriculture  Faisalabad Pakistan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8206-0802","authenticated-orcid":false,"given":"Yinong","family":"Zhang","sequence":"additional","affiliation":[{"name":"Guangdong Provincial Key Laboratory of Agro\u2010Animal Genomics and Molecular Breeding, College of Animal Science South China Agricultural University  Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0781-7593","authenticated-orcid":false,"given":"Jingchen","family":"Sun","sequence":"additional","affiliation":[{"name":"Guangdong Provincial Key Laboratory of Agro\u2010Animal Genomics and Molecular Breeding, College of Animal Science South China Agricultural University  Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huichao","family":"Yan","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Swine and Poultry Breeding Industry College of Animal Science National Engineering Research Center for Breeding Swine Industry\/Guangdong Laboratory for Lingnan Modern Agriculture\/Guangdong Provincial Key Laboratory of Animal Nutrition Control South China Agricultural University  Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,8,20]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"crossref","first-page":"108181","DOI":"10.18632\/oncotarget.22569","article-title":"SREBP\u20102\u2010driven transcriptional activation of human SND1 oncogene","volume":"8","author":"Armengol 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