{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T07:50:27Z","timestamp":1791532227762,"version":"4.3.4"},"reference-count":47,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T00:00:00Z","timestamp":1791504000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T00:00:00Z","timestamp":1791504000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["32302395"],"award-info":[{"award-number":["32302395"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Insect Science"],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Transcription factors are known to regulate detoxification gene expression and contribute to resistance to insecticides and acaricides in arthropods. Our previous study revealed that the nuclear hormone receptor PcHR96h is associated with spirodiclofen resistance in\n                    <jats:italic>Panonychus citri<\/jats:italic>\n                    , but its regulatory mechanism remains unclear. Here, we used DAP\u2010seq to identify genome\u2010wide targets of PcHR96h and found that ABC transporter genes were significantly enriched. Dual\u2010luciferase, yeast one\u2010hybrid, and EMSA assays verified that PcHR96h directly binds to the promoters of\n                    <jats:italic>PcABCA2<\/jats:italic>\n                    and\n                    <jats:italic>PcABCB2<\/jats:italic>\n                    . Functional validation via RNAi, subcellular localization, cytotoxicity tests, and molecular docking further confirmed that these two ABC transporters participate in spirodiclofen resistance. This study demonstrates that PcHR96h regulates specific ABC transporters involved in spirodiclofen resistance in\n                    <jats:italic>P. citri<\/jats:italic>\n                    , providing new insights into HR96\u2010driven detoxification and acaricide resistance.\n                  <\/jats:p>","DOI":"10.1111\/1744-7917.70373","type":"journal-article","created":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T07:19:21Z","timestamp":1791530361000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["A nuclear receptor PcHR96h regulates ABC transporters involved in spirodiclofen resistance in\n                    <i>Panonychus citri<\/i>"],"prefix":"10.1111","author":[{"given":"Sichen","family":"Li","sequence":"first","affiliation":[{"name":"Citrus Research Institute Southwest University, National Citrus Engineering Research Center  Chongqing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shijiang","family":"Yu","sequence":"additional","affiliation":[{"name":"Citrus Research Institute Southwest University, National Citrus Engineering Research Center  Chongqing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiqi","family":"Yang","sequence":"additional","affiliation":[{"name":"Citrus Research Institute Southwest University, National Citrus Engineering Research Center  Chongqing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zehao","family":"Huang","sequence":"additional","affiliation":[{"name":"Citrus Research Institute Southwest University, National Citrus Engineering Research Center  Chongqing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yang","family":"Li","sequence":"additional","affiliation":[{"name":"Citrus Research Institute Southwest University, National Citrus Engineering Research Center  Chongqing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mengxia","family":"Wang","sequence":"additional","affiliation":[{"name":"Citrus Research Institute Southwest University, National Citrus Engineering Research Center  Chongqing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meiyi","family":"Huang","sequence":"additional","affiliation":[{"name":"Citrus Research Institute Southwest University, National Citrus Engineering Research Center  Chongqing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shijun","family":"Fu","sequence":"additional","affiliation":[{"name":"Chongqing Kaizhou District Modern Agricultural Development Service Center  Chongqing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhen","family":"Wu","sequence":"additional","affiliation":[{"name":"Citrus Research Institute Southwest University, National Citrus Engineering Research Center  Chongqing 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China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lin","family":"Cong","sequence":"additional","affiliation":[{"name":"Citrus Research Institute Southwest University, National Citrus Engineering Research Center  Chongqing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8302-9188","authenticated-orcid":false,"given":"Chun","family":"Ran","sequence":"additional","affiliation":[{"name":"Citrus Research Institute Southwest University, National Citrus Engineering Research Center  Chongqing China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,10,9]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"crossref","first-page":"1321","DOI":"10.1073\/pnas.1515137113","article-title":"Nuclear hormone receptor DHR96 mediates the resistance to xenobiotics but not the increased lifespan of insulin\u2010mutant Drosophila","volume":"113","author":"Afschar 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