{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,31]],"date-time":"2025-07-31T00:30:28Z","timestamp":1753921828094},"reference-count":14,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2013,2,17]],"date-time":"2013-02-17T00:00:00Z","timestamp":1361059200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Ther Apher Dial"],"published-print":{"date-parts":[[2013,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Deceased donor kidney transplantation in long\u2010term dialysis patients in <jats:styled-content style=\"fixed-case\">J<\/jats:styled-content>apan has been increasing because of a severe lack of donors. Parathyroid glands of long\u2010term dialysis patients often show qualitative morphological changes from diffuse to nodular hyperplasia. Only a few studies have reported the clinicopathological analysis of persistent hyperparathyroidism after kidney transplantation in long\u2010term (&gt;10 years) dialysis patients. This study on consecutive deceased donor kidney transplantation performed from 2002 to 2010 measured biochemical parameters related to bone and mineral disorders and examined parathyroid tissues in parathyroidectomy cases. Thirty\u2010four subjects (22 males; mean age, 53.8\u2009\u00b1\u20097.9 years; mean dialysis period, 14.4\u2009\u00b1\u20094.3 years) were enrolled. Multivariate analysis of potential predictors for the hypercalcemia group at 12 months after transplantation showed that pre\u2010transplantation and early post\u2010transplantation calcium and parathyroid hormone levels were significant determinants. Pathological examination showed that a number of glands showed nodular hyperplasia, even in small glands weighing\u2009&lt;\u2009100\u2009mg. In long\u2010term dialysis patients, hyperparathyroidism and hypercalcemia developed at an early stage after transplantation and persisted for a long period (&gt;4 years), with nodular hyperplasia being found even in low\u2010weight parathyroid glands. Pre\u2010transplant high calcium and parathyroid hormone levels were the predictors for the prolonged hypercalcemia. Persistent hyperparathyroidism was considered to be caused by remaining nodular hyperplasia, even if the glands were small. Although the best treatment option is to perform a parathyroidectomy in the waiting period before transplantation, we suggest that it be performed in cases with prolonged hypercalcemia of &gt;6 months after transplantation.<\/jats:p>","DOI":"10.1111\/1744-9987.12018","type":"journal-article","created":{"date-parts":[[2013,2,18]],"date-time":"2013-02-18T19:35:45Z","timestamp":1361216145000},"page":"551-556","source":"Crossref","is-referenced-by-count":14,"title":["Clinicopathological Analysis of Persistent Hypercalcemia and Hyperparathyroidism After Kidney Transplantation in Long\u2010Term Dialysis Patients"],"prefix":"10.1111","volume":"17","author":[{"given":"Michio","family":"Nakamura","sequence":"first","affiliation":[{"name":"Department of Transplant Surgery Tokai University School of Medicine  Isehara Kanagawa Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kiho","family":"Tanaka","sequence":"additional","affiliation":[{"name":"Kidney Center Toranomon Hospital  Minato\u2010ku Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuhji","family":"Marui","sequence":"additional","affiliation":[{"name":"Kidney Center Toranomon Branch Hospital  Kawasaki Kanagawa Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shinji","family":"Tomikawa","sequence":"additional","affiliation":[{"name":"Kidney Center Toranomon Hospital  Minato\u2010ku Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2013,2,17]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0041-1345(00)00833-2"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2362.2006.01662.x"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-6143.2005.00938.x"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.ASN.0000100127.54107.57"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1093\/ndt\/gfh128"},{"key":"e_1_2_6_7_1","doi-asserted-by":"crossref","first-page":"1242","DOI":"10.1681\/ASN.V1261242","article-title":"Parathyroidectomy in patients on renal replacement therapy: an epidemiologic study","volume":"12","author":"Malberti F","year":"2001","journal-title":"J Am Soc Nephrol"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1007\/s002680010230"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1093\/ndt\/gfm044"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1098-2388(199703\/04)13:2<78::AID-SSU3>3.0.CO;2-Z"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9629(15)40552-X"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI116720"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1038\/ki.1997.41"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1038\/ki.2009.414"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.ki.5001549"}],"container-title":["Therapeutic Apheresis and Dialysis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2F1744-9987.12018","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/1744-9987.12018","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,12]],"date-time":"2023-09-12T03:59:14Z","timestamp":1694491154000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/1744-9987.12018"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,2,17]]},"references-count":14,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2013,10]]}},"alternative-id":["10.1111\/1744-9987.12018"],"URL":"https:\/\/doi.org\/10.1111\/1744-9987.12018","archive":["Portico"],"relation":{},"ISSN":["1744-9979","1744-9987"],"issn-type":[{"value":"1744-9979","type":"print"},{"value":"1744-9987","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,2,17]]}}}