{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,10]],"date-time":"2026-09-10T15:14:00Z","timestamp":1789053240707,"version":"build-2803163510"},"reference-count":25,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2013,7,3]],"date-time":"2013-07-03T00:00:00Z","timestamp":1372809600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Ther Apher Dial"],"published-print":{"date-parts":[[2014,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>We evaluated cystatin\u2010<jats:styled-content style=\"fixed-case\">C<\/jats:styled-content> (cys<jats:styled-content style=\"fixed-case\">C<\/jats:styled-content>) in the umbilical blood as a predictor of acute kidney injury (<jats:styled-content style=\"fixed-case\">AKI<\/jats:styled-content>) after perinatal hypoxia\/asphyxia compared with creatinine (<jats:styled-content style=\"fixed-case\">Cr<\/jats:styled-content>). One hundred full\u2010term newborns were enrolled in the study (50 in a group affected by perinatal hypoxia\/asphyxia [<jats:styled-content style=\"fixed-case\">AS] <\/jats:styled-content>and 50 controls). <jats:styled-content style=\"fixed-case\">CysC<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">Cr<\/jats:styled-content> were measured in blood samples from the umbilical cord at birth (<jats:styled-content style=\"fixed-case\">cysC<\/jats:styled-content>\u2010umb and <jats:styled-content style=\"fixed-case\">C<\/jats:styled-content>r\u2010umb) and from a peripheral vein 3 days later (<jats:styled-content style=\"fixed-case\">cysC<\/jats:styled-content>\u20103 and <jats:styled-content style=\"fixed-case\">Cr<\/jats:styled-content>\u20103). At birth, the mean level of <jats:styled-content style=\"fixed-case\">cysC<\/jats:styled-content> in healthy term babies was found to be 1.39 \u00b1 0.19 mg\/L and 1.34 \u00b1 0.21 mg\/L after 3 days of life, not significantly decreased (<jats:italic>P<\/jats:italic>\u2009=\u20090.137). The mean of <jats:styled-content style=\"fixed-case\">cysC<\/jats:styled-content> in the <jats:styled-content style=\"fixed-case\">AS<\/jats:styled-content> group was 2.12\u2009\u00b1\u20090.53\u2009mg\/<jats:styled-content style=\"fixed-case\">L<\/jats:styled-content> in cord blood and 1.56\u2009\u00b1\u20090.32\u2009g\/L in day 3 blood samples, also decreased (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.001) and different from the control (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.001). <jats:styled-content style=\"fixed-case\">Cr<\/jats:styled-content> levels, determined simultaneously at birth were different (<jats:italic>P<\/jats:italic>\u2009=\u20090.001) between the control (62.74\u2009\u00b1\u200912.84\u2009\u03bcmol\/<jats:styled-content style=\"fixed-case\">L<\/jats:styled-content>) and <jats:styled-content style=\"fixed-case\">AS<\/jats:styled-content> (72.60\u2009\u00b1\u200915.55\u2009\u03bcmol\/<jats:styled-content style=\"fixed-case\">L<\/jats:styled-content>) group, significantly decreased after 3 days in both groups (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.001). The receiver\u2010operating characteristic curve analysis, comparing <jats:styled-content style=\"fixed-case\">AS<\/jats:styled-content> and the control group, showed area under the curve for <jats:styled-content style=\"fixed-case\">cysC<\/jats:styled-content>\u2010umb, <jats:styled-content style=\"fixed-case\">cysC<\/jats:styled-content>\u20103, <jats:styled-content style=\"fixed-case\">C<\/jats:styled-content>r\u2010umb and <jats:styled-content style=\"fixed-case\">Cr<\/jats:styled-content>\u20103 (0.918; 0.698; 0.692; 0.660). The highest diagnostic accuracy was achieved with a chosen cut\u2010off for <jats:styled-content style=\"fixed-case\">cysC<\/jats:styled-content>\u2010umb of 1.67\u2009mg\/<jats:styled-content style=\"fixed-case\">L<\/jats:styled-content> (sensitivity of 84.0%, specificity of 90.0%) or 1.69\u2009mg\/<jats:styled-content style=\"fixed-case\">L<\/jats:styled-content> (sensitivity of 82.0%, specificity of 94.0%). Our results indicate serum <jats:styled-content style=\"fixed-case\">CysC<\/jats:styled-content> is a more sensitive marker of glomerular filtration rate than <jats:styled-content style=\"fixed-case\">C<\/jats:styled-content>r in the newborns.<\/jats:p>","DOI":"10.1111\/1744-9987.12054","type":"journal-article","created":{"date-parts":[[2013,7,3]],"date-time":"2013-07-03T12:36:59Z","timestamp":1372855019000},"page":"57-67","source":"Crossref","is-referenced-by-count":34,"title":["Serum Cystatin\u2010<scp>C<\/scp> as a Marker of Acute Kidney Injury in the Newborn After Perinatal Hypoxia\/Asphyxia"],"prefix":"10.1111","volume":"18","author":[{"given":"Milena","family":"Treiber","sequence":"first","affiliation":[{"name":"Clinical Department of Gynecology and Perinatology Unit of Neonatology  Maribor Slovenia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maksimiljan","family":"Gorenjak","sequence":"additional","affiliation":[{"name":"Department of Clinical Chemistry University Medical Center Maribor  Maribor Slovenia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Breda","family":"Pecovnik Balon","sequence":"additional","affiliation":[{"name":"Faculty of Medicine University of Maribor  Maribor Slovenia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2013,7,3]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpeds.2010.11.010"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00868721"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.ki.5002231"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1097\/00008480-200204000-00006"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00467-008-1060-2"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1136\/adc.57.2.123"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1515\/CCLM.1999.064"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1067\/mob.2001.115283"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1093\/ndt\/gfl073"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00467-008-0991-y"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1136\/adc.82.1.71"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1177\/147323000303100310"},{"key":"e_1_2_6_14_1","first-page":"2017","article-title":"Longitudinal study of cystatin C in healthy term newborns","volume":"66","author":"Albuquerque Cavalcanti Ferreira Novo AC","year":"2011","journal-title":"Clinics"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1093\/ndt\/gfs051"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00508-006-0555-8"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12098-011-0655-y"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-2007-993874"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00467-008-0867-1"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1093\/tropej\/fmi017"},{"key":"e_1_2_6_21_1","first-page":"928","article-title":"Renal failure in asphyxiated neonates","volume":"42","author":"Gupta BD","year":"2005","journal-title":"Indian Pediatr"},{"key":"e_1_2_6_22_1","doi-asserted-by":"publisher","DOI":"10.1179\/146532811X12925735813922"},{"key":"e_1_2_6_23_1","doi-asserted-by":"publisher","DOI":"10.1136\/fn.77.1.F57"},{"key":"e_1_2_6_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpeds.2006.03.053"},{"key":"e_1_2_6_25_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00467-012-2162-4"},{"key":"e_1_2_6_26_1","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.2003.050062"}],"container-title":["Therapeutic Apheresis and Dialysis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2F1744-9987.12054","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/1744-9987.12054","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,30]],"date-time":"2023-09-30T00:33:55Z","timestamp":1696034035000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/1744-9987.12054"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,7,3]]},"references-count":25,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2014,2]]}},"alternative-id":["10.1111\/1744-9987.12054"],"URL":"https:\/\/doi.org\/10.1111\/1744-9987.12054","archive":["Portico"],"relation":{},"ISSN":["1744-9979","1744-9987"],"issn-type":[{"value":"1744-9979","type":"print"},{"value":"1744-9987","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,7,3]]}}}