{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T04:13:43Z","timestamp":1790914423302,"version":"4.1.0"},"reference-count":21,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2013,8,11]],"date-time":"2013-08-11T00:00:00Z","timestamp":1376179200000},"content-version":"vor","delay-in-days":10,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Ther Apher Dial"],"published-print":{"date-parts":[[2013,8]]},"abstract":"Abstract<\/jats:title>Serum creatine kinase (CK<\/jats:styled-content>) is routinely used as a marker in the assessment of rhabdomyolysis and acute myoglobinuric kidney injury (Mb<\/jats:styled-content>\u2010AKI<\/jats:styled-content>), while the use of myoglobin is much less explored in this respect. We retrospectively analyzed the incidence of Mb<\/jats:styled-content>\u2010AKI<\/jats:styled-content> (creatinine [Cr]\u2009<\/jats:styled-content>>\u2009200\u2009\u03bcmol\/L) and the need for hemodialysis (HD<\/jats:styled-content>) in 484 patients (70.5% males) with suspected rhabdomyolysis, grouped according to peak serum myoglobin (A: 1\u20135\u2009mg\/L, B: 5\u201315\u2009mg\/L, C: >15\u2009mg\/L). The median peak myoglobin was 7163\u2009\u03bcg\/L. Both peak Cr<\/jats:styled-content> and peak CK<\/jats:styled-content> were significantly higher in group C. The incidence of Mb<\/jats:styled-content>\u2010AKI<\/jats:styled-content> was 24.6% in group A, 38.6% in group B (P<\/jats:italic>\u2009<\u20090.01 vs. group A), and significantly higher (64.9%) in group C (P<\/jats:italic>\u2009<\u20090.001 vs. groups A and B). Fifty\u2010one patients (10.5%) needed HD<\/jats:styled-content>, the proportion increasing from 6.7% in group A, and 12.3% in group B (NS<\/jats:styled-content>), to 28.1% in group C (P<\/jats:italic>\u2009<\u20090.001 vs. group A, P<\/jats:italic> 0.01 vs. group B), and reaching 36.8% with myoglobin >20\u2009mg\/L. Creatine kinase correlated with the severity of rhabdomyolysis, but less so with Mb<\/jats:styled-content>\u2010AKI<\/jats:styled-content>. The peak Cr<\/jats:styled-content> levels were not significantly different between patients divided by CK<\/jats:styled-content> 60\u2009\u03bckat\/L, or grouped into CK<\/jats:styled-content> tertiles or quartiles. A significant proportion of patients with rhabdomyolysis experienced Mb<\/jats:styled-content>\u2010AKI<\/jats:styled-content>, whose frequency increased in parallel with myoglobin levels. Myoglobin levels above 15\u2009mg\/L were most significantly related to the development of AKI<\/jats:styled-content> and the need for HD. Blood myoglobin could serve as a valuable early predictor and marker of rhabdomyolysis and Mb<\/jats:styled-content>\u2010AKI<\/jats:styled-content>.<\/jats:p>","DOI":"10.1111\/1744-9987.12084","type":"journal-article","created":{"date-parts":[[2013,8,12]],"date-time":"2013-08-12T04:28:56Z","timestamp":1376281736000},"page":"391-395","source":"Crossref","is-referenced-by-count":52,"title":["Use of Myoglobin as a Marker and Predictor in Myoglobinuric Acute Kidney Injury"],"prefix":"10.1111","volume":"17","author":[{"given":"Vladimir","family":"Premru","sequence":"first","affiliation":[{"name":"Department of Nephrology University Medical Centre Ljubljana Ljubljana Slovenia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Janko","family":"Kova\u010d","sequence":"additional","affiliation":[{"name":"Department of Nephrology University Medical Centre Ljubljana Ljubljana Slovenia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rafael","family":"Ponikvar","sequence":"additional","affiliation":[{"name":"Department of Nephrology University Medical Centre Ljubljana Ljubljana Slovenia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2013,8,11]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.V1181553"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra0801327"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1186\/cc2978"},{"key":"e_1_2_8_5_1","first-page":"1583","article-title":"Factors predictive of acute renal failure in rhabdomyolysis","volume":"148","author":"Ward MM","year":"1988","journal-title":"Arch Intern Med"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1093\/ndt\/9.6.637"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00134-003-1800-5"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1177\/0885066611402150"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajem.2004.09.025"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.md.0000188565.48918.41"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-6576.2005.00577.x"},{"key":"e_1_2_8_12_1","doi-asserted-by":"crossref","first-page":"796","DOI":"10.1093\/clinchem\/40.5.796","article-title":"Immunoassays for serum and urine myoglobin: myoglobin clearance assessed as a risk factor for acute renal failure","volume":"40","author":"Wu AHB","year":"1994","journal-title":"Clin Chem"},{"key":"e_1_2_8_13_1","first-page":"246","article-title":"Myoglobin turnover\u2010influence of renal and extrarenal factors","volume":"91","author":"H\u00e4llgren R","year":"1987","journal-title":"J Lab Clin Med"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1258\/0004563001899870"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcrc.2010.04.002"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1373\/clinchem.2009.128546"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjsurg.2004.08.050"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.medcli.2011.05.021"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1097\/00003246-200210000-00006"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtcvs.2010.03.028"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF01707664"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1159\/000343564"}],"container-title":["Therapeutic Apheresis and Dialysis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2F1744-9987.12084","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/1744-9987.12084","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,12]],"date-time":"2023-09-12T03:37:35Z","timestamp":1694489855000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/1744-9987.12084"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,8]]},"references-count":21,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2013,8]]}},"alternative-id":["10.1111\/1744-9987.12084"],"URL":"https:\/\/doi.org\/10.1111\/1744-9987.12084","archive":["Portico"],"relation":{},"ISSN":["1744-9979","1744-9987"],"issn-type":[{"value":"1744-9979","type":"print"},{"value":"1744-9987","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,8]]}}}