{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,20]],"date-time":"2025-10-20T10:16:53Z","timestamp":1760955413859},"reference-count":26,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2013,8,11]],"date-time":"2013-08-11T00:00:00Z","timestamp":1376179200000},"content-version":"vor","delay-in-days":10,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Ther Apher Dial"],"published-print":{"date-parts":[[2013,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The kinetics of myoglobin in severe rhabdomyolysis and dialysis\u2010dependent myoglobinuric acute kidney injury (<jats:styled-content style=\"fixed-case\">Mb<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">AKI<\/jats:styled-content>) is still not well elucidated, and more detailed knowledge could improve the now empiric use of rapid extracorporeal myoglobin removal by high cut\u2010off (<jats:styled-content style=\"fixed-case\">HCO<\/jats:styled-content>) hemodialysis treatments. Eighteen adult patients with severe dialysis\u2010dependent <jats:styled-content style=\"fixed-case\">Mb<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">AKI<\/jats:styled-content> (median serum concentration of myoglobin 57.4\u2009mg\/L) participated in the prospective clinical study, assessing myoglobin kinetics during <jats:styled-content style=\"fixed-case\">HCO<\/jats:styled-content> hemodiafiltration (<jats:styled-content style=\"fixed-case\">HCO HDF<\/jats:styled-content>). High initial serum concentrations of myoglobin (median 57.4\u2009mg\/L), together with protracted myoglobin appearance in the blood, indicated a large accumulation of myoglobin in body fluids. Extra\u2010renal endogenous metabolic myoglobin clearance was delayed, with a slow exponential fall in serum myoglobin (t\u00bd 35\u2009h). A mean myoglobin clearance of 90\u201394\u2009mL\/min, a reduction ratio of 80%, and a rapid exponential fall (t\u00bd 1\u2009h) in serum and dialysate myoglobin were achieved by <jats:styled-content style=\"fixed-case\">HCO HDF<\/jats:styled-content>. Half of the cumulative myoglobin removal was accomplished in 3\u20135\u2009h, with an additional removal of 7% each hour thereafter. A 2.4\u2010fold rebound in serum myoglobin followed the <jats:styled-content style=\"fixed-case\">HCO<\/jats:styled-content> procedures. Large amounts of myoglobin are released into the circulation, and its endogenous metabolic clearance in dialysis\u2010dependent <jats:styled-content style=\"fixed-case\">Mb<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">AKI<\/jats:styled-content> is slow. Owing to its rapid and highly efficient myoglobin elimination, <jats:styled-content style=\"fixed-case\">HCO HDF<\/jats:styled-content> may represent a valuable tool in the initial management of severe <jats:styled-content style=\"fixed-case\">Mb<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">AKI<\/jats:styled-content>, with a potential for earlier application in the future.<\/jats:p>","DOI":"10.1111\/1744-9987.12085","type":"journal-article","created":{"date-parts":[[2013,8,12]],"date-time":"2013-08-12T04:28:56Z","timestamp":1376281736000},"page":"396-401","source":"Crossref","is-referenced-by-count":14,"title":["Some Kinetic Considerations in High Cut\u2010Off Hemodiafiltration for Acute Myoglobinuric Renal Failure"],"prefix":"10.1111","volume":"17","author":[{"given":"Vladimir","family":"Premru","sequence":"first","affiliation":[{"name":"Department of Nephrology University Medical Centre Ljubljana  Ljubljana 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