{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,6]],"date-time":"2026-11-06T20:42:00Z","timestamp":1793997720257,"version":"4.8.0"},"reference-count":30,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2013,8,11]],"date-time":"2013-08-11T00:00:00Z","timestamp":1376179200000},"content-version":"vor","delay-in-days":10,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Ther Apher Dial"],"published-print":{"date-parts":[[2013,8]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Hantaviruses can be associated with severe form of hemorrhagic fever with renal syndrome although there are only a few cases reporting chronic kidney disease after hantavirus infection. We report a severe nonresolving chronic renal failure after protracted Dobrava hantavirus infection successfully treated with corticosteroids. Ten days after working in a basement a 33\u2010year\u2010old man fell seriously ill, with high fever, chills, diffuse myalgia, headache and abdominal pain. After hospital admission a diagnosis of hemorrhagic fever with renal syndrome caused by Dobrava hantavirus was made. Acute oliguric kidney injury developed in the first 3 days after admission, in a few days diuresis restored and he became polyuric. Nevertheless renal failure persisted and he needed hemodialysis. Because of nonresolving kidney failure, nephrogenic diabetes insipidus and renoparenchymal arterial hypertension persisting 2 months after onset of symptoms, a kidney biopsy was performed, showing severe necrotizing tubulointerstitial nephritis. High dose methylprednisolone therapy was started and his renal function significantly improved. Two months later a second renal biopsy showed persisting elements of active necrotizing tubulointerstitial nephritis. We decided to stop corticosteroid treatment and introduced aldosterone antagonist eplerenon as anti\u2010fibrotic agent, and his renal function further improved and remained stable. Nine months later his serum creatinine concentration was 227\u2009\u03bcmol\/L, proteinuria 0.156\u2009g\/day and well controlled nephrogenic diabetes insipidus.<\/jats:p>","DOI":"10.1111\/1744-9987.12086","type":"journal-article","created":{"date-parts":[[2013,8,12]],"date-time":"2013-08-12T00:28:56Z","timestamp":1376267336000},"page":"402-406","source":"Crossref","is-referenced-by-count":10,"title":["Successful Treatment of Severe Hantavirus Nephritis With Corticosteroids: A Case Report and Literature Review"],"prefix":"10.1111","volume":"17","author":[{"given":"Maja","family":"Martinu\u010d Bergo\u010d","sequence":"first","affiliation":[{"name":"General Hospital Nova Gorica  Ljubljana Slovenia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jelka","family":"Lindi\u010d","sequence":"additional","affiliation":[{"name":"Department of Nephrology University Medical Centre Ljubljana  Ljubljana Slovenia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Damjan","family":"Kova\u010d","sequence":"additional","affiliation":[{"name":"Department of Nephrology University Medical Centre Ljubljana  Ljubljana Slovenia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Du\u0161an","family":"Ferluga","sequence":"additional","affiliation":[{"name":"Institute of Pathology Faculty of Medicine University of Ljubljana  Ljubljana Slovenia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jernej","family":"Pajek","sequence":"additional","affiliation":[{"name":"Department of Nephrology University Medical Centre Ljubljana  Ljubljana Slovenia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2013,8,11]]},"reference":[{"issue":"35","key":"e_1_2_5_2_1","first-page":"S72","article-title":"Mechanism of disease in hemorrhagic fever with renal syndrome","volume":"40","author":"Cosgriff 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