{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,9,13]],"date-time":"2023-09-13T23:11:11Z","timestamp":1694646671394},"reference-count":25,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2013,8,11]],"date-time":"2013-08-11T00:00:00Z","timestamp":1376179200000},"content-version":"vor","delay-in-days":10,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Ther Apher Dial"],"published-print":{"date-parts":[[2013,8]]},"abstract":"Abstract<\/jats:title>Peritonitis is a significant complication of peritoneal dialysis (PD<\/jats:styled-content>) and the most common cause of technique failure. Panton\u2010Valentine leukocidin (PVL<\/jats:styled-content>), a cytotoxin produced by certain strains of Staphylococcus aureus<\/jats:italic> (SA<\/jats:styled-content>), causes destruction of neutrophils, and is associated with severe invasive infections. We present a 2.5\u2010year\u2010old girl on PD<\/jats:styled-content>, who presented suddenly with an unusually fulminant and protracted course of peritonitis. Only a few hours after the onset of clinical signs, septic shock developed. PVL<\/jats:styled-content>\u2010positive methicillin\u2010sensitive SA<\/jats:styled-content> (MSSA<\/jats:styled-content>) was grown and initial empiric antibiotic treatment changed to flucloxacillin and rifampicin in order to minimize toxin production. In spite of adequate antibiotic treatment and PD<\/jats:styled-content>\u2010catheter removal, recovery was slow. No PD<\/jats:styled-content>\u2010related peritonitis in children associated with PVL<\/jats:styled-content>\u2010producing strains have been reported so far and no specific recommendation exists for treatment. We speculate that PVL<\/jats:styled-content> contributed to the severity and outcome of peritonitis in our patient.<\/jats:p>","DOI":"10.1111\/1744-9987.12092","type":"journal-article","created":{"date-parts":[[2013,8,12]],"date-time":"2013-08-12T04:28:56Z","timestamp":1376281736000},"page":"431-437","source":"Crossref","is-referenced-by-count":0,"title":["Fulminant Peritonitis Presumably Caused by Panton\u2010Valentine Leukocidin\u2010Positive Staphylococcus aureus<\/i> in a Girl on Peritoneal Dialysis"],"prefix":"10.1111","volume":"17","author":[{"given":"Nina","family":"Battelino","sequence":"first","affiliation":[{"name":"Department of Pediatric Nephrology University Medical Centre Ljubljana Ljubljana Slovenia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marko","family":"Pokorn","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases University Medical Centre Ljubljana Ljubljana Slovenia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nata\u0161a","family":"\u0160vent\u2010Ku\u010dina","sequence":"additional","affiliation":[{"name":"Institute of Microbiology and Immunology Medical Faculty University of Ljubljana Ljubljana Slovenia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Veronika","family":"Kri\u017ean\u2010Hergouth","sequence":"additional","affiliation":[{"name":"Institute of Microbiology and Immunology Medical Faculty University of Ljubljana Ljubljana Slovenia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gregor","family":"Novljan","sequence":"additional","affiliation":[{"name":"Department of Pediatric Nephrology University Medical Centre Ljubljana Ljubljana Slovenia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2013,8,11]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrneph.2011.135"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00467-008-1113-6"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.2006101158"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.3747\/pdi.2011.00091"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.01201-06"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.1271\/bbb.68.981"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jinf.2009.05.003"},{"key":"e_1_2_5_9_1","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.43.12.6147-6149.2005"},{"key":"e_1_2_5_10_1","first-page":"2018","volume-title":"Clinical Microbiology Procedures Handbook","author":"Leber AL","year":"2010"},{"key":"e_1_2_5_11_1","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.33.9.2233-2239.1995"},{"key":"e_1_2_5_12_1","unstructured":"NAPRTCS Annual Report.North American pediatric renal trials and collaborative studies.2011. [Accessed 20 Feb 2013.] Available from URL:https:\/\/web.emmes.com\/study\/ped\/annlrept\/annualrept2011.pdf"},{"key":"e_1_2_5_13_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.ki.5002523"},{"key":"e_1_2_5_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1473-3099(12)70238-4"},{"key":"e_1_2_5_15_1","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dki379"},{"key":"e_1_2_5_16_1","doi-asserted-by":"publisher","DOI":"10.1097\/INF.0b013e318133a85e"},{"key":"e_1_2_5_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(02)07877-7"},{"key":"e_1_2_5_18_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0912403107"},{"key":"e_1_2_5_19_1","doi-asserted-by":"crossref","first-page":"314","DOI":"10.1177\/089686080602600306","article-title":"Aseptic peritonitis and icodextrin","volume":"26","author":"Goffin E","year":"2006","journal-title":"Perit Dial Int"},{"key":"e_1_2_5_20_1","doi-asserted-by":"publisher","DOI":"10.1093\/ndt\/gfs603"},{"key":"e_1_2_5_21_1","first-page":"23","article-title":"Pharmacokinetics of antibiotics in tissues and tissue fluids: a review","volume":"74","author":"Cars O","year":"1990","journal-title":"Scand J Infect Dis Suppl"},{"key":"e_1_2_5_22_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469-0691.2008.02105.x"},{"key":"e_1_2_5_23_1","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.01401-10"},{"key":"e_1_2_5_24_1","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.01410-06"},{"key":"e_1_2_5_25_1","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1177\/089686080802800109","article-title":"Short\u2010term effects of a new bicarbonate\/lactate\u2010buffered and conventional peritoneal dialysis fluid on peritoneal and systemic inflammation in CAPD patients: a randomized controlled study","volume":"28","author":"Pajek J","year":"2008","journal-title":"Perit Dial Int"},{"key":"e_1_2_5_26_1","doi-asserted-by":"publisher","DOI":"10.1086\/380909"}],"container-title":["Therapeutic Apheresis and Dialysis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2F1744-9987.12092","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/1744-9987.12092","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,12]],"date-time":"2023-09-12T03:36:48Z","timestamp":1694489808000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/1744-9987.12092"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,8]]},"references-count":25,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2013,8]]}},"alternative-id":["10.1111\/1744-9987.12092"],"URL":"https:\/\/doi.org\/10.1111\/1744-9987.12092","archive":["Portico"],"relation":{},"ISSN":["1744-9979","1744-9987"],"issn-type":[{"value":"1744-9979","type":"print"},{"value":"1744-9987","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,8]]}}}