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A disturbed hypothalamic\u2010pituitary\u2010gonadal axis due to <jats:styled-content style=\"fixed-case\">CKD<\/jats:styled-content> is thought to contribute to androgen deficiency. Data from experimental studies support the hypothesis that exogenous administration of testosterone may induce the activation of the renin\u2013angiotensin system (<jats:styled-content style=\"fixed-case\">RAS<\/jats:styled-content>), the production of endothelin and the regulation of anti\u2010 or\/and proinflammatory cytokines involved in the pathogenesis of hypertension and kidney damage. On the other hand, low testosterone levels in male patients with <jats:styled-content style=\"fixed-case\">CKD<\/jats:styled-content> are paradoxically associated with a higher risk of morbidity and mortality, possibly explained by anemia, osteoporosis and cardiovascular disease. In this article, we present an overview of clinical and experimental studies of the impact of testosterone on the progression and prognosis of male patients with <jats:styled-content style=\"fixed-case\">CKD<\/jats:styled-content>; even today, this remains a controversial issue.<\/jats:p>","DOI":"10.1111\/1744-9987.12101","type":"journal-article","created":{"date-parts":[[2013,10,12]],"date-time":"2013-10-12T01:42:28Z","timestamp":1381542148000},"page":"220-230","source":"Crossref","is-referenced-by-count":37,"title":["Role of Testosterone in the Pathogenesis, Progression, Prognosis and Comorbidity of Men With Chronic Kidney Disease"],"prefix":"10.1111","volume":"18","author":[{"given":"Periklis","family":"Dousdampanis","sequence":"first","affiliation":[{"name":"Hemodialysis Unit Kyanos Stavros Patras  Patras Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Konstantina","family":"Trigka","sequence":"additional","affiliation":[{"name":"Hemodialysis Unit Kyanos 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