{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,10,2]],"date-time":"2023-10-02T07:15:41Z","timestamp":1696230941969},"reference-count":36,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2014,6,26]],"date-time":"2014-06-26T00:00:00Z","timestamp":1403740800000},"content-version":"vor","delay-in-days":25,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Main Research Project MSM","award":["002160819","PRVOUK-P25\/LF1\/2"],"award-info":[{"award-number":["002160819","PRVOUK-P25\/LF1\/2"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Ther Apher Dial"],"published-print":{"date-parts":[[2014,6]]},"abstract":"Abstract<\/jats:title>Intraperitoneal glucose degradation products (GDP<\/jats:styled-content>) load influences systemic advanced glycation end products (AGEs<\/jats:styled-content>) but the effects on soluble receptor for AGEs<\/jats:styled-content> (s\u2010RAGE<\/jats:styled-content>) and its proinflammatory ligands: extracellular newly identified receptor for advanced glycation end\u2010products binding protein(EN\u2010RAGE<\/jats:styled-content>) and high mobility group box\u20101 protein (HMGB<\/jats:styled-content>\u20101) are unknown. We aimed to compare plasma and peritoneal s\u2010RAGE<\/jats:styled-content>, EN\u2010RAGE<\/jats:styled-content> and HMGB<\/jats:styled-content>\u20101 between three peritoneal dialysis (PD)<\/jats:styled-content> prescription regimens with different intraperitoneal GDP<\/jats:styled-content> loads. High GDP<\/jats:styled-content> load (glucose\u2010lactate PD<\/jats:styled-content> fluid, D<\/jats:styled-content>; N<\/jats:styled-content><\/jats:italic>\u2009=\u20098) was compared with a low (glucose\u2010bicarbonate\/lactate with icodextrin for overnight dwell, E<\/jats:styled-content>; N<\/jats:styled-content><\/jats:italic>\u2009=\u20099) and a very low GDP<\/jats:styled-content> load (glucose\u2010bicarbonate\/lactate, P<\/jats:styled-content>; N<\/jats:styled-content><\/jats:italic>\u2009=\u200916). D<\/jats:styled-content> group demonstrated higher plasma EN\u2010RAGE<\/jats:styled-content>, 77.8\u2009ng\/mL, vs. both E<\/jats:styled-content>, 11.2, P<\/jats:styled-content><\/jats:italic>\u2009<\u20090.001 and P<\/jats:styled-content>, 27.0, P<\/jats:styled-content><\/jats:italic>\u2009<\u20090.001 as well as higher plasma HMGB<\/jats:styled-content>\u20101, 2.2\u2009ng\/mL vs. both E<\/jats:styled-content>, 1.1, P<\/jats:styled-content><\/jats:italic>\u2009<\u20090.01 and P<\/jats:styled-content><\/jats:italic>, 1.5, P<\/jats:styled-content><\/jats:italic>\u2009<\u20090.01. Plasma s\u2010RAGE,<\/jats:styled-content> which did not differ between D<\/jats:styled-content>, E<\/jats:styled-content> and P,<\/jats:styled-content> correlated with its effluent levels. Patients with faster peritoneal transport (D\/P<\/jats:styled-content>cr > 0.65) tended to have higher plasma s\u2010RAGE<\/jats:styled-content> compared to slow transporters (2300 vs. 1762\u2009pg\/mL, P<\/jats:styled-content><\/jats:italic>\u2009=\u20090.056). Peritoneal clearance of s\u2010RAGE<\/jats:styled-content> and EN\u2010RAGE<\/jats:styled-content> was higher with E compared to both D<\/jats:styled-content> and P<\/jats:styled-content> (P<\/jats:styled-content><\/jats:italic>\u2009<\u20090.001 resp. P<\/jats:styled-content><\/jats:italic>\u2009<\u20090.01). Subgroup of PD<\/jats:styled-content> patients with CRP<\/jats:styled-content> above median demonstrated higher plasma HMGB<\/jats:styled-content>\u20101 and EN\u2010RAGE<\/jats:styled-content>, P<\/jats:styled-content><\/jats:italic>\u2009<\u20090.05 for both. A lower intraperitoneal GDP<\/jats:styled-content> load is associated with decreased plasma levels of EN\u2010RAGE<\/jats:styled-content> and HMGB<\/jats:styled-content>\u20101. Peritoneal transport, microinflammation and the capability of icodextrin to increase peritoneal clearance of middle molecular weight substances might also exert an effect on plasma s\u2010RAGE<\/jats:styled-content> and its proinflammatory ligands levels.<\/jats:p>","DOI":"10.1111\/1744-9987.12103","type":"journal-article","created":{"date-parts":[[2015,10,13]],"date-time":"2015-10-13T03:13:57Z","timestamp":1444706037000},"page":"309-316","source":"Crossref","is-referenced-by-count":4,"title":["Low Glucose Degradation Product Peritoneal Dialysis Regimen Is Associated With Lower Plasma EN\u2010RAGE<\/scp> and HMGB<\/scp>\u20101 Proinflammatory Ligands of Receptor for Advanced Glycation End Products"],"prefix":"10.1111","volume":"18","author":[{"given":"Sylvie","family":"Opatrna","sequence":"first","affiliation":[{"name":"Medicine I Charles University Medical School Pilsen Czech Republic"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anna","family":"Popperlova","sequence":"additional","affiliation":[{"name":"Medicine I Charles University Medical School Pilsen Czech Republic"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marta","family":"Kalousov\u00e1","sequence":"additional","affiliation":[{"name":"Medicine I Charles University Medical School Pilsen Czech Republic"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tomas","family":"Zima","sequence":"additional","affiliation":[{"name":"Medicine I Charles University Medical School Pilsen Czech 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