{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,4,29]],"date-time":"2025-04-29T07:47:48Z","timestamp":1745912868667},"reference-count":27,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2014,6,26]],"date-time":"2014-06-26T00:00:00Z","timestamp":1403740800000},"content-version":"vor","delay-in-days":25,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Ther Apher Dial"],"published-print":{"date-parts":[[2014,6]]},"abstract":"Abstract<\/jats:title>Cognitive impairment has long been recognized as a complication of chronic kidney disease. However, there is little information available regarding regional cerebral blood flow (rCBF<\/jats:styled-content>) in patients with peritoneal dialysis (PD<\/jats:styled-content>). Therefore, we evaluated rCBF<\/jats:styled-content> using brain single photon emission computed tomography (SPECT<\/jats:styled-content>). We conducted a cross\u2010sectional study in our hospital. Eighteen consecutive PD<\/jats:styled-content> patients who could visit the hospital by themselves without any history of stroke were examined by T<\/jats:styled-content>echnetium\u201099\u2009m\u2010labeled ethylcrysteinate dimer brain SPECT<\/jats:styled-content>. An easy Z\u2010score imaging system (eZIS<\/jats:styled-content>) was used to compare rCBF<\/jats:styled-content> in PD<\/jats:styled-content> patients with those in age\u2010matched healthy controls. We also evaluated cognitive dysfunction with the mini\u2010mental state examination (MMSE<\/jats:styled-content>) questionnaire. Only one patient showed an MMSE<\/jats:styled-content> score of 18 points, and the remaining 14 patients were considered as normal (MMSE<\/jats:styled-content>\u2009\u2265\u200927), and three patients were considered to have mild cognitive impairment (24\u2009\u2264\u2009MMSE<\/jats:styled-content>\u2009\u2264\u200926). In all patients, rCBF<\/jats:styled-content> in the posterior cingulated gyri, precunei, and parietal cortices was significantly decreased. The ratio of the reduction of rCBF<\/jats:styled-content> in each region relative to that of rCBF<\/jats:styled-content> across the whole brain correlated positively with the PD<\/jats:styled-content> duration (r\u2009=\u20090.559; P<\/jats:italic>\u2009<\u20090.05). The serum \u03b22\u2010microglobulin level was significantly higher in patients who had a higher ratio of rCBF<\/jats:styled-content> reduction compared with those with lower ratios. In conclusion, all PD<\/jats:styled-content> patients in the present study had decreased rCBF<\/jats:styled-content> irrespective of MMSE<\/jats:styled-content> scores.<\/jats:p>","DOI":"10.1111\/1744-9987.12107","type":"journal-article","created":{"date-parts":[[2015,10,13]],"date-time":"2015-10-13T14:19:26Z","timestamp":1444745966000},"page":"291-296","source":"Crossref","is-referenced-by-count":9,"title":["Cerebral Blood Flow in Patients With Peritoneal Dialysis by an Easy Z\u2010Score Imaging System for Brain Perfusion Single\u2010Photon Emission Tomography"],"prefix":"10.1111","volume":"18","author":[{"given":"Rei","family":"Isshiki","sequence":"first","affiliation":[{"name":"Department of Nephrology, Immunology, and Vascular Medicine Shonan Kamakura General Hospital Kanagawa Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shuzo","family":"Kobayashi","sequence":"additional","affiliation":[{"name":"Department of Nephrology, Immunology, and Vascular Medicine Shonan Kamakura General Hospital Kanagawa Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masao","family":"Iwagami","sequence":"additional","affiliation":[{"name":"Department of Nephrology, Immunology, and Vascular Medicine Shonan Kamakura General Hospital Kanagawa Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daimu","family":"Tsutumi","sequence":"additional","affiliation":[{"name":"Department of Nephrology, Immunology, and Vascular Medicine Shonan Kamakura General Hospital Kanagawa Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yasuhiro","family":"Mochida","sequence":"additional","affiliation":[{"name":"Department of Nephrology, Immunology, and Vascular Medicine Shonan Kamakura General Hospital Kanagawa Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kunihiro","family":"Ishioka","sequence":"additional","affiliation":[{"name":"Department of Nephrology, Immunology, and Vascular Medicine Shonan 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