{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T20:53:20Z","timestamp":1793566400144,"version":"4.5.0"},"reference-count":25,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2014,2,25]],"date-time":"2014-02-25T00:00:00Z","timestamp":1393286400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Ther Apher Dial"],"published-print":{"date-parts":[[2014,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Hypertension is a major risk factor for cardiovascular and cerebrovascular events, and most patients with hypertension are administered antihypertensive drugs. However, not all patients achieve normal blood pressure levels. The new angiotensin receptor blocker azilsartan (<jats:styled-content style=\"fixed-case\">T<\/jats:styled-content>akeda <jats:styled-content style=\"fixed-case\">P<\/jats:styled-content>harmaceutical <jats:styled-content style=\"fixed-case\">C<\/jats:styled-content>ompany <jats:styled-content style=\"fixed-case\">L<\/jats:styled-content>imited, <jats:styled-content style=\"fixed-case\">O<\/jats:styled-content>saka, <jats:styled-content style=\"fixed-case\">J<\/jats:styled-content>apan) has been reported to have a strong hypotensive effect. Our study investigated the efficacy of azilsartan compared with other angiotensin receptor blockers. This study included 17 hypertensive patients on HD, who had been administered angiotensin receptor blockers, except for azilsartan, for more than 6 months before enrolling, and after enrollment, they were switched to azilsartan. Blood tests, Holter electrocardiogram, ambulatory blood pressure monitoring, and echocardiography were performed at baseline and at the 6\u2010month follow\u2010up. The blood pressure from baseline to 6 months had significantly decreased (24\u2010h systolic blood pressure from 150.9\u2009\u00b1\u200916.2\u2009mm\u2009Hg to 131.3\u2009\u00b1\u200921.7\u2009mm\u2009Hg, <jats:italic>P<\/jats:italic>\u2009=\u20090.008), awakening time systolic blood pressure from 152.1\u2009\u00b1\u200916.9\u2009mm\u2009Hg to 131.7\u2009\u00b1\u200923.2\u2009mm\u2009Hg, <jats:italic>P<\/jats:italic>\u2009=\u20090.01, sleep\u2010time systolic blood pressure from 148.1\u2009\u00b1\u200919.7\u2009mm\u2009Hg to 130.0\u2009\u00b1\u200920.1\u2009mm\u2009Hg, <jats:italic>P<\/jats:italic>\u2009=\u20090.005). There was a significant reduction in serum noradrenaline levels as well as left ventricular mass index after switching to azilsartan (from 550.1\u2009\u00b1\u2009282.9\u2009pg\/mL, to 351.7\u2009\u00b1\u2009152.3\u2009pg\/mL, <jats:italic>P<\/jats:italic>\u2009=\u20090.002; from 117.0\u2009\u00b1\u200926.4\u2009g\/m<jats:sup>2<\/jats:sup> to 111.3\u2009\u00b1\u200923.9\u2009g\/m<jats:sup>2<\/jats:sup>, <jats:italic>P<\/jats:italic>\u2009=\u20090.01, respectively). Azilsartan had a significantly stronger hypotensive effect than other angiotensin receptor blockers. Thus, the switch to azilsartan might improve prognosis of hemodialysis patients. We suggest that the strong anti\u2010hypertensive effect of azilsartan originated from a combination of primary angiotensin receptor blocker class\u2010effect and a stronger suppression of sympathetic nervous system.<\/jats:p>","DOI":"10.1111\/1744-9987.12168","type":"journal-article","created":{"date-parts":[[2014,2,25]],"date-time":"2014-02-25T07:07:01Z","timestamp":1393312021000},"page":"398-403","source":"Crossref","is-referenced-by-count":12,"title":["Effects of Azilsartan Compared to Other Angiotensin Receptor Blockers on Left Ventricular Hypertrophy and the Sympathetic Nervous System in Hemodialysis Patients"],"prefix":"10.1111","volume":"18","author":[{"given":"Takanori","family":"Kusuyama","sequence":"first","affiliation":[{"name":"Department of Cardiology Tsukazaki Hospital  Himeji Hyogo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hirohito","family":"Ogata","sequence":"additional","affiliation":[{"name":"Department of Cardiology Tsukazaki Hospital  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