{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T14:57:44Z","timestamp":1787065064686,"version":"build-2736575974"},"reference-count":20,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2014,3,27]],"date-time":"2014-03-27T00:00:00Z","timestamp":1395878400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Ther Apher Dial"],"published-print":{"date-parts":[[2014,10]]},"abstract":"Abstract<\/jats:title>\n \n Therapeutic plasma apheresis or exchange (\n TPE<\/jats:styled-content>\n ) in the pediatric population is technically challenging. Moreover, there is generally an apprehension in using\n TPE<\/jats:styled-content>\n in children compared to adults. Recently, usage of\n TPE<\/jats:styled-content>\n has evolved and is now being used in heterogenous clinical conditions. Its usefulness is classified by the\n A<\/jats:styled-content>\n merican\n S<\/jats:styled-content>\n ociety for\n A<\/jats:styled-content>\n pheresis (\n ASFA<\/jats:styled-content>\n ) into various categories ranging from\n I<\/jats:styled-content>\n to\n IV<\/jats:styled-content>\n . The objective of this paper was to review the procedure in context of clinical indications, complications and outcomes in children. For this purpose, we retrospectively reviewed all\n TPE<\/jats:styled-content>\n procedures performed on inpatients of 3 to 16 years of age during a 6\u2010year period (2007\u20132012). A total of 130 procedures were performed on 28 patients (\n M<\/jats:styled-content>\n :\n F<\/jats:styled-content>\n ratio of 1:1) with median age (range) of 8.8 (4\u201316) years. All procedures were done using the continuous cell\u2010separator centrifugal method. Due to organ dysfunctions, the majority of procedures (\n N<\/jats:italic>\n \u2009=\u200926 of 28 or 92% patients) were performed in the pediatric intensive care unit. Twenty\u2010three, four and one patient belonged to\n ASFA<\/jats:styled-content>\n categories\n I<\/jats:styled-content>\n ,\n II<\/jats:styled-content>\n and\n III,<\/jats:styled-content>\n respectively. The most common indications were neurological disorders (\n N<\/jats:italic>\n \u2009=\u200913 or 46.4%), comprised of\n G<\/jats:styled-content>\n uillain\u2013\n B<\/jats:styled-content>\n arr\u00e9 syndrome (\n N<\/jats:italic>\n \u2009=\u200910) and myasthenia gravis (\n N<\/jats:italic>\n \u2009=\u20093). Hematological disorders (\n N<\/jats:italic>\n \u2009=\u200910 or 35.7%) including thrombotic thrombocytopenic purpura\u2010hemolytic uremic syndrome were a close second. Complete recovery was seen in 23 patients (84%). Trivial adverse effects were observed in 18\/130 (13.8%) procedures. Major complications including cardiac arrest, hypotension and transfusion\u2010related acute lung injury were observed in 5\/130 or 3.8% of procedures. However, there was no procedure\u2010related death though five patients died during treatment due to underlying pathology. In conclusion,\n TPE<\/jats:styled-content>\n is a safe and effective option in sick children for appropriate indications. An experienced staff with sound procedural skills is imperative for successful therapy.\n <\/jats:p>","DOI":"10.1111\/1744-9987.12173","type":"journal-article","created":{"date-parts":[[2014,3,27]],"date-time":"2014-03-27T04:22:58Z","timestamp":1395894178000},"page":"497-501","source":"Crossref","is-referenced-by-count":23,"title":["Feasibility of Pediatric Plasma Apheresis in Intensive Care Settings"],"prefix":"10.1111","volume":"18","author":[{"given":"Anwarul","family":"Haque","sequence":"first","affiliation":[{"name":"Department of Pediatrics & Child Health Aga Khan University Hospital Karachi Pakistan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gul","family":"Sher","sequence":"additional","affiliation":[{"name":"Department of Pediatrics & Child Health Aga Khan University Hospital Karachi Pakistan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mehar","family":"Hoda","sequence":"additional","affiliation":[{"name":"Department of Pediatrics & Child Health Aga Khan University Hospital Karachi Pakistan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bushra","family":"Moiz","sequence":"additional","affiliation":[{"name":"Department of Pathology and Microbiology Aga Khan University Hospital Karachi Pakistan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2014,3,27]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1182\/asheducation.V2012.1.7.3797920"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/jca.20240"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1537-2995.2009.02505.x"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1473-0502(03)00111-3"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1473-0502(03)00120-4"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/jca.20034"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1744-9987.2011.00998.x"},{"key":"e_1_2_6_9_1","first-page":"57","article-title":"Plasamapheresis technique, Complications and Indications at The Isra University Hospital Hyderabad","volume":"17","author":"Ujjan I","year":"2011","journal-title":"Q Med Channel"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1098-1101(2000)15:1\/2<129::AID-JCA7>3.0.CO;2-H"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1525-139X.2011.01028.x"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/jca.21242"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/jca.20059"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/jca.20038"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.transci.2011.09.002"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.transci.2006.06.008"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.transci.2007.11.002"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12098-012-0779-8"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1526-0968.2001.00353.x"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1537-2995.2007.01405.x"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.transci.2013.04.020"}],"container-title":["Therapeutic Apheresis and Dialysis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2F1744-9987.12173","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/1744-9987.12173","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,29]],"date-time":"2023-09-29T15:00:48Z","timestamp":1695999648000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/1744-9987.12173"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,3,27]]},"references-count":20,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2014,10]]}},"alternative-id":["10.1111\/1744-9987.12173"],"URL":"https:\/\/doi.org\/10.1111\/1744-9987.12173","archive":["Portico"],"relation":{},"ISSN":["1744-9979","1744-9987"],"issn-type":[{"value":"1744-9979","type":"print"},{"value":"1744-9987","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,3,27]]}}}