{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,29]],"date-time":"2025-12-29T13:47:17Z","timestamp":1767016037061,"version":"3.37.3"},"reference-count":34,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2014,3,27]],"date-time":"2014-03-27T00:00:00Z","timestamp":1395878400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Ther Apher Dial"],"published-print":{"date-parts":[[2014,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Renal anemia, uremic myopathy, and malnutrition are some of the factors that affect the results of the 6\u2010minute walk test (6<jats:styled-content style=\"fixed-case\">MWT<\/jats:styled-content>) in hemodialysis patients. We hypothesized that skeletal muscle dysfunction caused by skeletal myolysis, protein hypercatabolism, and mitochondrial deficiency are strongly related factors. The purpose of this study was to clarify the factors that affect the 6<jats:styled-content style=\"fixed-case\">MWT<\/jats:styled-content> results in hemodialysis patients to assess their exercise tolerance. The study included 43 outpatients from the hemodialysis unit. The 6<jats:styled-content style=\"fixed-case\">MWT<\/jats:styled-content> was performed, and knee extension strength, 1\u2010leg standing time, and grip were measured. In addition, the subjects' characteristics such as age, preexisting coronary artery disease, hemoglobin level, total iron binding capacity, serum albumin level, creatinine generation rate, and normalized protein catabolic rate were investigated. A stepwise multiple regression model was used to examine the factors affecting the 6<jats:styled-content style=\"fixed-case\">MWT<\/jats:styled-content> results. Multiple regression analysis revealed that knee extension strength (\u03b2\u2009=\u20090.446, <jats:italic>P<\/jats:italic>\u2009=\u20090.001), total iron binding capacity (\u03b2\u2009=\u2009\u22120.299, <jats:italic>P<\/jats:italic>\u2009=\u20090.021), and preexisting coronary artery disease (\u03b2\u2009=\u2009\u22120.272, <jats:italic>P<\/jats:italic>\u2009=\u20090.035) significantly affected the 6<jats:styled-content style=\"fixed-case\">MWT<\/jats:styled-content> results (R\u2009=\u20090.66, R<jats:sup>2<\/jats:sup>\u2009=\u20090.44). The 6<jats:styled-content style=\"fixed-case\">MWT<\/jats:styled-content> in hemodialysis patients was strongly affected by muscle strength, iron deficiency anemia, and preexisting coronary artery disease, suggesting that resistance training is important for improving 6<jats:styled-content style=\"fixed-case\">MWT<\/jats:styled-content> results. Our findings indicate that iron deficiency and cardiac function should be assessed before exercising or undergoing an exercise tolerance test.<\/jats:p>","DOI":"10.1111\/1744-9987.12177","type":"journal-article","created":{"date-parts":[[2014,3,27]],"date-time":"2014-03-27T07:44:49Z","timestamp":1395906289000},"page":"623-627","source":"Crossref","is-referenced-by-count":30,"title":["Investigation of Factors Affecting the Six\u2010Minute Walk Test Results in Hemodialysis Patients"],"prefix":"10.1111","volume":"18","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6498-7161","authenticated-orcid":false,"given":"Kenichi","family":"Kono","sequence":"first","affiliation":[{"name":"Department of Rehabilitation Aichi Medical College  Kiyosu Aichi Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yusuke","family":"Nishida","sequence":"additional","affiliation":[{"name":"Department of Rehabilitation Seirei Christopher University  Hamamatsu Shizuoka Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yoshihumi","family":"Moriyama","sequence":"additional","affiliation":[{"name":"Wellness Center Nagoya Kyoritsu Hospital  Nagoya Aichi Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiroki","family":"Yabe","sequence":"additional","affiliation":[{"name":"Department of Rehabilitation Nagoya Kyoritsu Hospital  Nagoya Aichi Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masahiro","family":"Taoka","sequence":"additional","affiliation":[{"name":"Hemodialysis Center Meiko Kyoritsu Clinic  Nagoya Aichi Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takashi","family":"Sato","sequence":"additional","affiliation":[{"name":"Hemodialysis Center Meiko Kyoritsu Clinic  Nagoya Aichi Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2014,3,27]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1744-9987.2012.01143.x"},{"key":"e_1_2_6_3_1","first-page":"738","article-title":"Effects of exercise training on exercise aerobic capacity and quality of life in hemodialysis patients","volume":"21","author":"Capitanini A","year":"2008","journal-title":"J Nephrol"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.ackd.2009.09.002"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1523-1755.2004.00411.x"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.284.6329.1607"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1093\/gerona\/51A.4.M147"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-8703(99)70114-6"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0828-282X(08)70569-5"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1093\/oxfordjournals.eurheartj.a060258"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-8703(98)70219-4"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1097\/01823246-201021010-00003"},{"key":"e_1_2_6_13_1","unstructured":"Ministry of Education Culture Sports Science and Technology.2000New fitness test implementation guideline (in Japanese). 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