{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,9,6]],"date-time":"2024-09-06T05:20:25Z","timestamp":1725600025349},"reference-count":28,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2014,9,4]],"date-time":"2014-09-04T00:00:00Z","timestamp":1409788800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Ther Apher Dial"],"published-print":{"date-parts":[[2014,10]]},"abstract":"Abstract<\/jats:title>This study is aimed at exploring the role of serum fibroblast growth factor\u201023 (FGF<\/jats:styled-content>\u201023), matrix G<\/jats:styled-content>la (MGP)<\/jats:styled-content> and F<\/jats:styled-content>etuin\u2010A<\/jats:styled-content> in the calcium\u2010phosphate metabolism and estimate the value of serum FGF<\/jats:styled-content>\u201023, MGP<\/jats:styled-content> and F<\/jats:styled-content>etuin\u2010A<\/jats:styled-content> levels in predicting osteoporosis in maintenance hemodialysis (MHD<\/jats:styled-content>) patients. This study included 64 patients who receive hemodialysis in our hospital. The serum FGF<\/jats:styled-content>\u201023, MGP<\/jats:styled-content> and F<\/jats:styled-content>etuin\u2010A<\/jats:styled-content> were analyzed by enzyme\u2010linked immunosorbent assay (ELlSA<\/jats:styled-content>). Bone mineral density (BMD<\/jats:styled-content>) at the femoral neck was measured by dual\u2010energy X<\/jats:styled-content>\u2010ray absorptiometry. The 64 patients (30 males, 34 females, 60.6\u2009\u00b1\u200911.3 years of age) received an average of 6.88\u2009\u00b1\u20092.94 years of dialysis. Body mass index (BMI)<\/jats:styled-content>, K<\/jats:styled-content>t\/V<\/jats:styled-content>, dialysis vintage, patient age, serum levels of FGF<\/jats:styled-content>\u201023, F<\/jats:styled-content>etuin\u2010A<\/jats:styled-content>, bone isoenzyme of alkaline phosphatase (ALP<\/jats:styled-content>\u2010B<\/jats:styled-content>), and calcium were different in statistical significance among the three groups of patients in terms of normal bone mass (N\u2009=<\/jats:italic>\u200910), osteopenia (N =<\/jats:italic>\u200924), or osteoporosis (N =<\/jats:italic>\u200930). BMI<\/jats:styled-content>, K<\/jats:styled-content>t\/V<\/jats:styled-content>, ALP<\/jats:styled-content>\u2010B<\/jats:styled-content>, dialysis vintage and serum F<\/jats:styled-content>etuin\u2010A<\/jats:styled-content> level were identified as independent variables of femoral neck BMD<\/jats:styled-content> by stepwise multiple regression analysis. The area under ROC<\/jats:styled-content> curve showed that serum F<\/jats:styled-content>etuin\u2010A<\/jats:styled-content> was useful for identifying osteoporosis in MHD<\/jats:styled-content> patients. The cutoff value corresponding to the highest Y<\/jats:styled-content>ouden's index was serum F<\/jats:styled-content>etuin\u2010A<\/jats:styled-content> \u226489\u2009\u03bcg\/mL, which was defined as the optimal predictor of osteoporosis. Its sensitivity\/specificity was 71%\/77.8%. The incidence of osteoporosis is high in MHD<\/jats:styled-content> patients. Serum F<\/jats:styled-content>etuin\u2010A<\/jats:styled-content> level is closely correlated with osteoporosis and it may serve as a predictor of osteoporosis.<\/jats:p>","DOI":"10.1111\/1744-9987.12194","type":"journal-article","created":{"date-parts":[[2014,9,5]],"date-time":"2014-09-05T05:29:00Z","timestamp":1409894940000},"page":"427-433","source":"Crossref","is-referenced-by-count":6,"title":["Effect of Serum Fibroblast Growth Factor\u201023, Matrix G<\/scp>la Protein and F<\/scp>etuin\u2010A<\/scp> in Predicting Osteoporosis in Maintenance Hemodialysis Patients"],"prefix":"10.1111","volume":"18","author":[{"given":"Qing","family":"Wu","sequence":"first","affiliation":[{"name":"Division of Nephrology The Fifth People's Hospital of Shanghai Fudan University Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dong\u2010Mei","family":"Xiao","sequence":"additional","affiliation":[{"name":"Division of Nephrology The Fifth People's Hospital of Shanghai Fudan 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