{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,8]],"date-time":"2026-06-08T12:29:42Z","timestamp":1780921782852,"version":"3.54.1"},"reference-count":18,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2014,6,26]],"date-time":"2014-06-26T00:00:00Z","timestamp":1403740800000},"content-version":"vor","delay-in-days":25,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Ther Apher Dial"],"published-print":{"date-parts":[[2014,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Palmoplantar pustulosis (<jats:styled-content style=\"fixed-case\">PPP<\/jats:styled-content>) is characterized by neutrophilic pustules with erythema, which are limited to the hands and feet. Although granulocyte and monocyte adsorption apheresis (<jats:styled-content style=\"fixed-case\">GMA<\/jats:styled-content>) has shown remarkable effects on generalized pustular psoriasis, there are few reports of <jats:styled-content style=\"fixed-case\">PPP<\/jats:styled-content> treated with <jats:styled-content style=\"fixed-case\">GMA<\/jats:styled-content>. We treated three refractory <jats:styled-content style=\"fixed-case\">PPP<\/jats:styled-content> patients using <jats:styled-content style=\"fixed-case\">GMA<\/jats:styled-content> weekly for 5 weeks. The skin eruptions were assessed by a 5\u2010grade score for scales, pustules, and erythema. <jats:styled-content style=\"fixed-case\">GMA<\/jats:styled-content> decreased the total grade from 9 to 2 in patients 1 and 2, and from 7 to 3 in patient 3. The <jats:styled-content style=\"fixed-case\">GMA<\/jats:styled-content> effects were estimated to be excellent in all three patients. Pustule formation and pain disappeared in all cases. The treatment effect lasted for at least 5 months after <jats:styled-content style=\"fixed-case\">GMA<\/jats:styled-content>. <jats:styled-content style=\"fixed-case\">GMA<\/jats:styled-content> was also effective for relieving the arthralgia in one patient, but it recurred at 6 weeks. Based on these findings, <jats:styled-content style=\"fixed-case\">GMA<\/jats:styled-content> could be an effective therapy for refractory <jats:styled-content style=\"fixed-case\">PPP<\/jats:styled-content>.<\/jats:p>","DOI":"10.1111\/1744-9987.12210","type":"journal-article","created":{"date-parts":[[2015,10,13]],"date-time":"2015-10-13T04:22:03Z","timestamp":1444710123000},"page":"238-243","source":"Crossref","is-referenced-by-count":14,"title":["Efficacy of Granulocyte and Monocyte Adsorption Apheresis for Treatment of Palmoplantar Pustulosis"],"prefix":"10.1111","volume":"18","author":[{"given":"Tomomi","family":"Fujisawa","sequence":"first","affiliation":[{"name":"Department of Dermatology Gifu University Graduate School of Medicine  Gifu Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chisato","family":"Tawada","sequence":"additional","affiliation":[{"name":"Department of Dermatology Gifu University Graduate School of Medicine  Gifu 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