{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,9]],"date-time":"2026-03-09T06:56:35Z","timestamp":1773039395545,"version":"3.50.1"},"reference-count":16,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2014,6,26]],"date-time":"2014-06-26T00:00:00Z","timestamp":1403740800000},"content-version":"vor","delay-in-days":25,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Ther Apher Dial"],"published-print":{"date-parts":[[2014,6]]},"abstract":"Abstract<\/jats:title>We devised a method of plasma exchange with dialysis (PED<\/jats:styled-content>), in which selective plasma exchange (sPE<\/jats:styled-content>) is performed using a selective membrane plasma separator (EC\u20102A<\/jats:styled-content>) with an albumin\u2010sieving coefficient of 0.3 while the dialysate flows outside the hollow fibers, and reported the usefulness of the system for treating acute liver failure. Thereafter, EC\u20104A<\/jats:styled-content> with an albumin\u2010sieving coefficient of 0.6 was developed, which was expected to be even more effective for removing protein\u2010bound substances. In order to examine whether or not EC\u20104A<\/jats:styled-content> might be applicable to blood purification therapy against drug poisoning, we compared the efficacies of sPE, PED<\/jats:styled-content>, and direct hemoperfusion (DHP<\/jats:styled-content>) using an activated carbon column for the removal of phenobarbital and lithium. Subjects undergoing the extracorporeal circulation study were assigned to the sPE group, PED<\/jats:styled-content> group, or DHP<\/jats:styled-content> group, and the changes in the blood concentrations of phenobarbital and lithium were measured over 180\u2009min. A significant decrease of the phenobarbital concentration over time was seen in the PED<\/jats:styled-content> group, as compared to that in the sPE<\/jats:styled-content> group (P<\/jats:italic>\u2009<\u20090.0001), while no significant difference in the concentration was observed between the PED<\/jats:styled-content> and DHP<\/jats:styled-content> groups. The PED<\/jats:styled-content> group showed a significant decrease of the lithium concentration over time, as compared to the DHP<\/jats:styled-content> group (P<\/jats:italic>\u2009<\u20090.0001), while no significant difference in the concentration was observed between the PED<\/jats:styled-content> and sPE<\/jats:styled-content> groups. Thus, PED<\/jats:styled-content> was as effective as DHP<\/jats:styled-content> for removing phenobarbital and was as effective as sPE for removing lithium. These results suggest that PED<\/jats:styled-content> therapy using EC\u20104A<\/jats:styled-content> may be a feasible modality for the treatment of drug poisoning.<\/jats:p>","DOI":"10.1111\/1744-9987.12214","type":"journal-article","created":{"date-parts":[[2015,10,13]],"date-time":"2015-10-13T13:05:33Z","timestamp":1444741533000},"page":"265-271","source":"Crossref","is-referenced-by-count":7,"title":["Removal of Toxic Substances by a Selective Membrane Plasma Separator"],"prefix":"10.1111","volume":"18","author":[{"given":"Hajime","family":"Nakae","sequence":"first","affiliation":[{"name":"Department of Emergency and Critical Care Medicine Akita University Graduate School of Medicine Akita Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tomoko","family":"Hattori","sequence":"additional","affiliation":[{"name":"Kawasumi Laboratories, Inc. Akita Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Toshiko","family":"Igarashi","sequence":"additional","affiliation":[{"name":"Department of Emergency and Critical Care Medicine Akita University Graduate School of Medicine Akita Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Manabu","family":"Okuyama","sequence":"additional","affiliation":[{"name":"Department of Emergency and Critical Care Medicine Akita University Graduate School of Medicine Akita Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kimitaka","family":"Tajimi","sequence":"additional","affiliation":[{"name":"Department of Emergency and Critical Care Medicine Akita University Graduate School of Medicine Akita Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2014,6,26]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1744-9987.2010.00864.x"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1744-9987.2011.00969.x"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1744-9987.2012.01112.x"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1159\/000314857"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1001\/archinte.1989.00390010054004"},{"key":"e_1_2_6_7_1","first-page":"85","article-title":"Performance evaluation of membrane plasma separators and plasma fractionators using bovine blood","volume":"25","author":"Mineshima M","year":"2006","journal-title":"Jpn J Apher"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1053\/ajkd.2000.16207"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1093\/ndt\/gfh221"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.jcp.0000218405.02738.b3"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.smj.0000257619.25995.c4"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.5694\/j.1326-5377.1991.tb121225.x"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1139\/y69-170"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.4009\/jsdt.36.1701"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V81.5.1263.1263"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI115124"},{"key":"e_1_2_6_17_1","first-page":"460","article-title":"Basic study of PHEMA coated bead active carbon for direct hemoperfusion","volume":"8","author":"Nakashima T","year":"1979","journal-title":"Jpn J Artif Organs"}],"container-title":["Therapeutic Apheresis and Dialysis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2F1744-9987.12214","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/1744-9987.12214","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,1]],"date-time":"2023-10-01T09:33:28Z","timestamp":1696152808000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/1744-9987.12214"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,6]]},"references-count":16,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2014,6]]}},"alternative-id":["10.1111\/1744-9987.12214"],"URL":"https:\/\/doi.org\/10.1111\/1744-9987.12214","archive":["Portico"],"relation":{},"ISSN":["1744-9979","1744-9987"],"issn-type":[{"value":"1744-9979","type":"print"},{"value":"1744-9987","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,6]]}}}