{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,27]],"date-time":"2026-06-27T04:27:48Z","timestamp":1782534468777,"version":"3.54.5"},"reference-count":21,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2014,9,4]],"date-time":"2014-09-04T00:00:00Z","timestamp":1409788800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Ther Apher Dial"],"published-print":{"date-parts":[[2015,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The incidence of hypokalemia in continuous ambulatory peritoneal dialysis<jats:styled-content style=\"fixed-case\"> (CAPD)<\/jats:styled-content> patients is about 15\u201360%, leading to significant complications. There is no standard treatment other than potassium supplement in this setting. The aim of this study was to evaluate effect of spironolactone 25\u2009mg\/day in <jats:styled-content style=\"fixed-case\">CAPD<\/jats:styled-content> patients who have a history of hypokalemia. This is a randomized, double\u2010blind, placebo\u2010controlled, cross\u2010over study in <jats:styled-content style=\"fixed-case\">CAPD<\/jats:styled-content> patients who had a history of hypokalemia. Study intervention is 4 weeks of oral spironolactone 25\u2009mg\/day or placebo, cross\u2010over after a 2\u2010week wash\u2010out period. The primary outcome was the difference of serum potassium before and after 4 weeks of spironolactone treatment. Serum potassium was measured every 2 weeks, serum magnesium, urine and peritoneal fluid potassium measured before and after each treatment period. We enrolled 24 patients, and 20 completed the cross\u2010over study. Ten patients were anuric. The total doses of potassium supplement were the same during the study period. Serum potassium levels before and after study intervention were not significantly different in both groups (4.23\u2009\u00b1\u20090.64 vs. 3.90\u2009\u00b1\u20090.59\u2009mEq\/L for spironolactone <jats:italic>P<\/jats:italic>\u2009=\u20090.077 and 3.84\u2009\u00b1\u20090.62 vs. 3.91\u2009\u00b1\u20090.52 for placebo <jats:italic>P<\/jats:italic>\u2009=\u20090.551). Total 24\u2010h potassium, magnesium, sodium excretion, urine volume and ultrafiltration volume were not affected by spironolactone or placebo. There was one episode of hyperkalemia (5.6\u2009mEq\/L) during the spironolactone treatment period. Spironolactone 25\u2009mg\/day does not have a significant effect on serum potassium or urine and peritoneal excretion rate in <jats:styled-content style=\"fixed-case\">CAPD<\/jats:styled-content> patients who have a history of hypokalemia.<\/jats:p>","DOI":"10.1111\/1744-9987.12219","type":"journal-article","created":{"date-parts":[[2014,9,5]],"date-time":"2014-09-05T05:29:59Z","timestamp":1409894999000},"page":"81-86","source":"Crossref","is-referenced-by-count":32,"title":["Randomized, Double\u2010Blind, Placebo\u2010Controlled Trial of Spironolactone for Hypokalemia in Continuous Ambulatory Peritoneal Dialysis Patients"],"prefix":"10.1111","volume":"19","author":[{"given":"Somchai","family":"Yongsiri","sequence":"first","affiliation":[{"name":"Facutly of Medicine Burapha University  Mueng Chonburi Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiranuch","family":"Thammakumpee","sequence":"additional","affiliation":[{"name":"Internal Medicine Department Chonburi Hospital  Mueng Chonburi Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Suriya","family":"Prongnamchai","sequence":"additional","affiliation":[{"name":"Facutly of Medicine Burapha University  Mueng Chonburi Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pechngam","family":"Tengpraettanakorn","sequence":"additional","affiliation":[{"name":"Facutly of Medicine Burapha University  Mueng Chonburi Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rachaneeporn","family":"Chueansuwan","sequence":"additional","affiliation":[{"name":"Facutly of Medicine Burapha University  Mueng Chonburi Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Siriporn","family":"Tangjaturonrasme","sequence":"additional","affiliation":[{"name":"Facutly of Medicine Burapha University  Mueng Chonburi Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pakaphan","family":"Dinchuthai","sequence":"additional","affiliation":[{"name":"Facutly of Medicine Burapha University  Mueng Chonburi Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2014,9,4]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.2011060607"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1525-139X.2010.00789.x"},{"key":"e_1_2_8_4_1","doi-asserted-by":"crossref","first-page":"652","DOI":"10.1177\/089686089601600628","article-title":"Hypokalemia in peritoneal dialysis patients","volume":"16","author":"Khan AN","year":"1996","journal-title":"Perit Dial Int"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.ajkd.2005.03.015"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1093\/ndt\/gfn709"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1345\/aph.1R011"},{"key":"e_1_2_8_8_1","first-page":"507","article-title":"A prospective double\u2010blind randomized placebo\u2010controlled clinical trial to evaluate the safety and efficacy of spironolactone in patients with advanced congestive heart failure on continuous ambulatory peritoneal dialysis","volume":"23","author":"Taheri S","year":"2012","journal-title":"Saudi J Kidney Dis Transpl"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.2215\/CJN.09421209"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.2013030273"},{"issue":"1","key":"e_1_2_8_11_1","first-page":"17","article-title":"Aspects on pharmacokinetics of some diuretics. 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